Brain Activation During Silent Word Generation Evaluated with Functional MRI

Friedman, Lee; Kenny, John; Wise, Alexandria; Wu, Dee; Stuve, Traci A.; Miller, David A.; Jesberger, John A.; Lewin, Jonathan S.

doi:10.1006/brln.1998.1953

Cited by 146 publications

(94 citation statements)

References 52 publications

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“…The affected region is located at the junction of BA 21, 20, and 37. This region has been linked to higher-level modality-nonspecific language processing and word generation, 60,61 as well as reasoning. 62 Thinning in this region might affect language generation and similar functions in mTBI survivors, which in turn could contribute to impairment of cognitive and social functions in mTBI survivors.…”

Section: Early Cortical Thinning In Mtbi Survivors After Mvcsmentioning

confidence: 99%

Early Cortical Thickness Change after Mild Traumatic Brain Injury following Motor Vehicle Collision

Wang

Xie

Cotton

et al. 2015

Journal of Neurotrauma

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In a motor vehicle collision (MVC), survivors often receive mild traumatic brain injuries (mTBI). Although there have been some reports of early white matter changes after an mTBI, much less is known about early cortical structural changes. To investigate early cortical changes within a few days after an MVC, we compared cortical thickness of mTBI survivors with nonmTBI survivors, then reexamined cortical thickness in the same survivors 3 months later. MVC survivors were categorized as mTBI or non-mTBI based on concussive symptoms documented in emergency departments (EDs). Cortical thickness was measured from MRI images using FreeSurfer within a few days and again at 3 months after MVC. Post-traumatic stress symptoms and physical conditions were also assessed. Compared with the non-mTBI group (n = 23), the mTBI group (n = 21) had thicker cortex in the left rostral middle frontal (rMFG) and right precuneus gyri, but thinner cortex in the left posterior middle temporal gyrus at 7.2 -3.1 days after MVC. After 3 months, cortical thickness had decreased in left rMFG in the mTBI group but not in the non-mTBI group. The cortical thickness of the right precuneus region in the initial scans was positively correlated with acute traumatic stress symptoms for all survivors and with the number of reduced activity days for mTBI survivors who completed the follow-up. The preliminary results suggest that alterations in cortical thickness may occur at an early stage of mTBI and that frontal cortex structure may change dynamically over the initial 3 months after mTBI.

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Section: Early Cortical Thinning In Mtbi Survivors After Mvcsmentioning

confidence: 99%

Early Cortical Thickness Change after Mild Traumatic Brain Injury following Motor Vehicle Collision

Wang

Xie

Cotton

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

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“…Word retrieval was tested with the Boston Naming Test (BNT) (Tallberg, 2005) and a verbal fluency test (FAS) (Friedman et al, 1998;Loonstra, Tarlow, & Sellers, 2001). Language comprehension was measured with the BeSS test that determines subtle speech and language disorders (Laakso et al, 2000) and a reading comprehension task (READ) selected from the Swedish Scholastic Assessment Test (SeSAT) which is an instrument for selection to higher education (Stage & Ögren, 2004).…”

Section: Language Ability Testsmentioning

confidence: 99%

“…Broca's area, located in the left inferior frontal gyrus (IFG) and specified as BA 44 and 45, is often co-activated during reading paradigms (Lindenberg & Scheef, 2007;Vigneau et al, 2006;Bookheimer, 2002;Friederici, 2002). Word fluency is typically characterized in the brain by activation of Broca's area (Heim, Eickhoff, & Amunts, 2009), often accompanied by activation in adjacent prefrontal regions and also activation in the temporal and parietal cortices (Friedman et al, 1998;Fu et al, 2002;Gauthier, Duyme, Zanca, & Capron, 2009). Further, the anterior cingulate cortex (ACC) and the anterior insular cortex (AIC) are frequently engaged across a wide distribution of cognitive tasks, including language (Fu et al, 2002;Medford and Critchley, 2010).…”

Section: Introductionmentioning

confidence: 99%

Right-hemispheric cortical contributions to language ability in healthy adults

Ettinger-Veenstra¹,

Ragnehed²,

McAllister³

et al. 2012

Brain and Language

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In this study we investigated the correlation between individual linguistic ability based on performance levels and their engagement of typical and atypical language areas in the brain.Eighteen healthy subjects between 21 to 64 years participated in language ability tests, and subsequent functional MRI scans measuring brain activity in response to a sentence completion and a word fluency task. Performance in both reading and high-level language tests correlated positively with increased right-hemispheric activation in the inferior frontal gyrus (specifically Brodmann area 47), the dorsolateral prefrontal cortex (DLPFC), and the medial temporal gyrus (Brodmann area 21). In contrast, we found a negative correlation between performance and left-hemispheric DLPFC activation.Our findings indicate that the right lateral frontal and right temporal regions positively modulate aspects of language ability.

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“…Furthermore we used a verbal fluency test. The subject was cued with a letter (F, A, S) and had to generate as many words as possible within a minute (FAS-test, Friedman et al, 1998;Loonstra et al, 2001). The Swedish norm, depending on age and gender, is predictive of intellectual level (Tallberg et al, 2008).…”

Section: Disorders (Bedömning Av Subtila Språkstörningar [Assessment mentioning

confidence: 99%

Right-hemispheric brain activation correlates to language performance

et al. 2010

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Language function in the right-hemispheric homologues of Broca"s and Wernicke"s areas does not only correlate with left-handedness or pathology, but occurs naturally in righthanded healthy subjects as well. In the current study, two non-invasive methods of assessing language lateralization are correlated with behavioral results in order to link hemispheric dominance to language ability in healthy subjects.Functional Magnetic Resonance Imaging (fMRI) together with a sentence-completion paradigm was used to determine region-specific lateralization indices in the left-and rightsided Broca"s and Wernicke"s areas, the frontal temporal lobe, the anterior cingulate cortex and the parietal lobe. In addition, dichotic listening results were used to determine overall language lateralization and to strengthen conclusions by correlating with fMRI indices.Results showed that fMRI lateralization in the superior parietal, the posterior temporal, and the anterior cingulate cortices correlated to dichotic listening. A decreased right ear advantage (REA), which indicates less left-hemispheric dominance in language, correlated with higher performance in most administered language tasks, including reading, language ability, fluency, and non-word discrimination. Furthermore, right hemispheric involvement in the posterior temporal lobe and the homologue of Broca"s area suggests better performance in behavioral language tasks. This strongly indicates a supportive role of the right-hemispheric counterparts of Broca"s and Wernicke"s areas in language performance.

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Brain Activation During Silent Word Generation Evaluated with Functional MRI

Cited by 146 publications

References 52 publications

Early Cortical Thickness Change after Mild Traumatic Brain Injury following Motor Vehicle Collision

Early Cortical Thickness Change after Mild Traumatic Brain Injury following Motor Vehicle Collision

Right-hemispheric cortical contributions to language ability in healthy adults

Right-hemispheric brain activation correlates to language performance

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