Brain Activation by Acupuncture with “De-Qi”: a PET study

Hsieh, Jen-Chuen; Cheng, Fang-Pei; Tu, Chun-Hoaw; Tsai, Jea-Shen; Liao, Yu-Wan; Chiang, Tzu-Ching; Chen, Min-Chi; Liu, Ren-Shyan

doi:10.1016/s1053-8119(18)31273-4

Cited by 8 publications

(6 citation statements)

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“…Until recently, reports of activation far outnumber those of deactivation. Signal increases have been reported in the visual cortex, auditory cortex, primary, and secondary somatosensory cortices, supplementary motor cortex, cingulate cortex, thalamus, insula, hypothalamus, periaqueductal gray, and cerebellum [Biella et al, 2001;Cho et al, 1998Cho et al, , 2000Fang et al, 2004;Hsieh et al, 1998;Li et al, 2003a,b;Liu et al, 2004;Parrish et al, 2005;Yan et al, 2005;Yoo et al, 2004]. While the finding of activation in most of these regions is valid, the interpretation that the response was specific to the acupoints employed is unconvincing.…”

Section: Deactivation In the Limbic-paralimbicneocortical Networkmentioning

confidence: 99%

The salient characteristics of the central effects of acupuncture needling: Limbic‐paralimbic‐neocortical network modulation

Fang¹,

Zhou²,

Wang³

et al. 2008

Human Brain Mapping

247

213

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Human and animal studies suggest that acupuncture produces many beneficial effects through the central nervous system. However, the neural substrates of acupuncture actions are not completely clear to date. fMRI studies at Hegu (LI4) and Zusanli (ST36) indicated that the limbic system may play an important role for acupuncture effects. To test if this finding applies to other major classical acupoints, fMRI was performed on 10 healthy adults during manual acupuncture at Taichong (LV3), Xingjian (LV2), Neiting (ST44), and a sham point on the dorsum of the left foot. Although certain differences could be observed between real and sham points, the hemodynamic response (BOLD signal changes) and psychophysical response (sensory experience) to acupuncture were generally similar for all four points. Acupuncture produced extensive deactivation of the limbic-paralimbic-neocortical system. Clusters of deactivated regions were seen in the medial prefrontal cortex (frontal pole, pregenual cingulate), the temporal lobe (amygdala, hippocampus, and parahippocampus) and the posterior medial cortex (precuneus, posterior cingulate). The sensorimotor cortices (somatosensory cortices, supplementary motor cortex), thalamus and occasional paralimbic structures such as the insula and anterior middle cingulate cortex showed activation. Our results provide additional evidence in support of previous reports that acupuncture modulates the limbic-paralimbic-neocortical network. We hypothesize that acupuncture may mediate its antipain, antianxiety, and other therapeutic effects via this intrinsic neural circuit that plays a central role in the affective and cognitive dimensions of pain as well as in the regulation and integration of emotion, memory processing, autonomic, endocrine, immunological, and sensorimotor functions.

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Section: Deactivation In the Limbic-paralimbicneocortical Networkmentioning

confidence: 99%

The salient characteristics of the central effects of acupuncture needling: Limbic‐paralimbic‐neocortical network modulation

Fang¹,

Zhou²,

Wang³

et al. 2008

Human Brain Mapping

247

213

View full text Add to dashboard Cite

show abstract

“…Anknüpfungspunkte zur Frage zerebraler Mechanismen der Schmerzlinderung durch Akupunktur ergeben sich aus Daten, welche ebenfalls mit Hilfe der funktionellen Bildgebung am Gehirn erhoben wurden. Erste Beobachtungen mit der Positronenemissionstomographie (PET) [18] und der funktionellen Kernspintomographie (fMRI) [19] zeigen, dass ein Akupunkturreiz zu einer Modulation der Aktivierung umschriebener Hirnstrukturen führt, die mit der zerebralen Verarbeitung von Schmerzen assoziiert sind. Es handelt sich in großer Übereinstimmung um die gleichen Strukturen, die wahrscheinlich den Angriffspunkt für pharmakologische Wirkungen von Opioiden darstellen [11].…”

Section: Zerebrale Mechanismenunclassified

Wirkung der Akupunktur auf die affektive und sensorische Schmerzbewertung

Hammes¹,

Flatau²,

Bäcker³

et al. 2002

Schmerz

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“…Data from these studies demonstrate that acupuncture stimulation elicits response within multiple cortical, subcortical, limbic and brainstem areas [for review see1, 18, 49, 54-58]. Although, it may appear that the present data demonstrating localization of evoked MEG brain response to SI cortex conflicts with previous fMRI findings of distributed brain response to acupuncture, it is important to acknowledge differences in imaging modality and experimental design/analysis that may affect which brain areas appear to be active during acupuncture.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal Mapping the Neural Correlates of Acupuncture with MEG

Dhond

Witzel

Hämäläinen

et al. 2008

The Journal of Alternative and Complementary Medicine

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Acupuncture is an ancient Eastern healing modality with putative therapeutic applications. Unfortunately, little is known about the central mechanisms by which acupuncture may exert its effects. In this study, fifteen healthy subjects were evaluated with magnetoencephalography (MEG) to map the location and timing of brain activity during low frequency electroacupuncture (EA) and, mechanical, non-insertive, sham acupuncture (SA) given at acupoint PC-6. Both EA and SA evoked brain responses that localized to contralateral primary somatosensory (SI) cortex. However, initial responses for EA peaked slightly earlier than those for SA and were located inferiorly within SI. Average equivalent current dipole (ECD) strength was stronger (particularly at latencies >60ms) for SA. These spatiotemporal differences between activations elicited by EA and SA are likely attributable to stimulus modality (electrical vs. mechanical) and differences in the underlying somatosensory fibers transmitting these signals. The present data confirm that acupuncture modulates activity within somatosensory cortex, providing support for previous studies which suggest that acupunctures therapeutic effects are linked to SI modulation. Thus, MEG provides excellent spatiotemporal characterization of the somatosensory component of acupuncture, and future studies can contrast derived brain response parameters in healthy controls with those found in a diseased state.

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Brain Activation by Acupuncture with “De-Qi”: a PET study

Cited by 8 publications

References 0 publications

The salient characteristics of the central effects of acupuncture needling: Limbic‐paralimbic‐neocortical network modulation

The salient characteristics of the central effects of acupuncture needling: Limbic‐paralimbic‐neocortical network modulation

Wirkung der Akupunktur auf die affektive und sensorische Schmerzbewertung

Spatiotemporal Mapping the Neural Correlates of Acupuncture with MEG

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