Brain abscesses associated with pulmonary arteriovenous malformations

Brydon, Howard L.; Akinwunmi, James; Selway, Richard; Ulhaq, Imran

doi:10.1080/02688699943664

Cited by 22 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although hematogenous spreading was the pathogenetic mechanism for the BA, abscess lesions were multiple in only 1 case (case 3, first episode). 5 of 7 BA episodes were surgically treated, and, although difficult postsurgical management of PAVM patients has been reported in a neurosurgical setting [26], we did not observe any complications in our patients. …”

Section: Discussionsupporting

confidence: 47%

Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Brain Abscess

Gargiulo

Guastamacchia²,

Resta³

et al. 2006

Respiration

View full text Add to dashboard Cite

Hereditary hemorrhagic telangiectasia (HHT) is a systemic angiodysplasia inherited as an autosomal dominant disease. Patients with HHT and pulmonary arteriovenous malformations (PAVMs) are at increased risk for brain abscess (BA), a potentially preventable condition as effective treatment for PAVMs is available. In a center dedicated to HHT, a history of BA was found in 6 out of 128 patients with a definite diagnosis: herewith, their histories are reported focusing on mistakes in the diagnosis and management of the disease. Patients with PAVMs and BA had a higher mean hemoglobin concentration (15.1 g/dl vs. 12.2 g/dl, p < 0.006 by Student’s t test) compared to patients with PAVMs alone. Other clinical features (genetics, bacteriology, types of PAVMs, treatments, outcomes) are also discussed. Prompt diagnosis and screening for visceral involvement is pivotal for HHT patients and their relatives.

show abstract

Section: Discussionsupporting

confidence: 47%

Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Brain Abscess

Gargiulo

Guastamacchia²,

Resta³

et al. 2006

Respiration

View full text Add to dashboard Cite

show abstract

“…dental cleaning) if bacteria can bypass the pulmonary filtration system via right to left shunting from AVMs. 46 Polycythemia may occur if there is significant AV shunting. The locus designated as HHT3 appears to predispose to pulmonary AVM formation.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist’s perspective

2018

View full text Add to dashboard Cite

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is an autosomal dominant disorder that causes abnormal blood vessel formation. The diagnosis of hereditary hemorrhagic telangiectasia is clinical, based on the Curaçao criteria. Genetic mutations that have been identified include ENG, ACVRL1/ALK1, and MADH4/SMAD4, among others. Patients with HHT may have telangiectasias and arteriovenous malformations in various organs and suffer from many complications including bleeding, anemia, iron deficiency, and high-output heart failure. Families with the same mutation exhibit considerable phenotypic variation. Optimal treatment is best delivered via a multidisciplinary approach with appropriate diagnosis, screening and local and/or systemic management of lesions. Anti-angiogenic agents such as bevacizumab have emerged as a promising systemic therapy in reducing bleeding complications but are not curative. Other pharmacological agents include iron supplementation, antifibrinolytics and hormonal treatment. This review discusses the biology of HHT, management issues that face the practising hematologist, and considerations of future directions in HHT treatment.

show abstract

“…Figura 2. después de procedimientos "sucios" (por ejemplo, limpieza dental) (Brydon et al 1999) ,el diagnostico se basa en los criterios de curazao que consisten en epistaxis recurrente, telangiectasias, malformaciones vasculares viscerales y un familiar de primer grado con enfermedad de Rendu-Osler-Weber (el diagnóstico establecido se realiza con 3 o más de estos criterios) (Mosquera-Klinger, Cárdenas, and Valencia 2019). Aunque existe una predilección por el sangrado y la hemorragia, puede predisponer a los pacientes a manifestaciones trombóticas/embólicas como infarto de miocardio (Rao, Khan, and Aiello 2021) .…”

Section: Máculas Rojo Violáceas Redondeadas De 2 MM En Lenguaunclassified

Síndrome de Osler Weber Rendau en adulto mayor

2022

Ciencia Latina

View full text Add to dashboard Cite

Objetivo: Exponer las principales características clínicas para realizar el diagnostico de La telangiectasia hemorrágica hereditaria o síndrome de Osler-Weber-Rendu. Presentación de caso: Se presenta el caso de un paciente de 70 años con historia de epistaxis a repetición que consulta por hemorragia gastrointestinal cumpliendo criterios clínicos y paraclínicos para diagnóstico de síndrome de Osler-Weber-Rendu. Conclusión: se trata de un trastorno hemorrágico genético raro, pero mal reconocido, de gran importancia ya que pueden puede presentarse con malformaciones vasculares en múltiples áreas del cuerpo con sangrados significativos.

show abstract

Brain abscesses associated with pulmonary arteriovenous malformations

Cited by 22 publications

References 39 publications

Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Brain Abscess

Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Brain Abscess

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist’s perspective

Síndrome de Osler Weber Rendau en adulto mayor

Contact Info

Product

Resources

About