Brain abscess secondary to medication-induced osteonecrosis of the jaw

Yamada, Chiaki; Takahata, Sosuke; Nakagawa, Kiyoko; Yamamoto, Nao; Kogo, Mikihiko

doi:10.1016/j.ajoms.2016.04.007

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Effective management of maxillary lesions is particularly important as the lesion can extend further and lead to nasal septal abscess, orbital cellulitis, skull base necrosis, and brain abscess (Khan & Sindwani, ; Maeda, Matsunobu, Kurioka, Kurita, & Shiotani, ; Malik, Fernando, Laitt, & Leatherbarrow, ; Matsushita, Kamigaki, & Nakamura, ; Yamada, Takahata, Nakagawa, Yamamoto, & Kogo, ). The same principles of treatment apply to maxillary and mandibular MRONJ, namely complete removal of non‐vital bone followed by meticulous wound closure.…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

et al. 2018

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Purpose The management of maxillary medication‐related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single‐layer closure with mucoperiosteal flap and double‐layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators. Methods A retrospective analysis was conducted and included all surgically treated and followed‐up maxillary MRONJ cases in a single center. Demographics and clinical data, stage of MRONJ, surgical treatment, and treatment outcome were collected. Results Seventy‐nine lesions were included. Removal of necrotic bone was followed by coverage with mucoperiosteal flap in 60 lesions and BFPF in 14 lesions. Seven lesions (five primarily and two following unsuccessful treatment with BFPF) underwent necrectomy and were reconstructed with obturators. Complete mucosal healing was achieved in 76.7% of the lesions covered with mucoperiosteal flap. BFPF led to complete mucosal healing in 85.7% of the lesions. No complications were observed in the defects rehabilitated with obturators. Conclusion Removal of necrotic bone followed by closure with mucoperiosteal flap is reliable for MRONJ treatment. BFPF is effective for closure of MRONJ‐related oroantral communications (OACs).

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Section: Introductionmentioning

confidence: 99%

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

et al. 2018

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“…MRONJ nedeni ile beyne yayılım gösteren apse oluşumları da literatürde rapor edilmiştir. Çok nadir durumlarda sistemik septik enfeksiyonlar meydana gelebilir [38][39][40] .…”

Section: Mronj'un Klinik öZellikleriunclassified

Medication Related Osteonecrosis of Jaws and Current Treatment Modalities

Erdil

Soylu

Altan

et al. 2019

Arşiv Kaynak Tarama Dergisi

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Medication-related osteonecrosis of the jaws (MRONJ), resulting from maxillofacial surgical procedures applied during or after bisphosphonate, antiresorptive and antiangiogenic treatments is a recently defined disease and its etiopathogenesis is still unexplained. There are debates on the treatment approaches of the disease, and the commission established by the American Association for Maxillofacial Surgery publishes guidelines on the definition, staging and treatment procedures of the disease. Nowadays, surgical and conservative treatment methods are used depending on the impact level of bone and soft tissues. It is of utmost importance to prevent the occurence of this disease in patients, who are referred to oral and maxillofacial surgeons, informed about this disease and from the most recent guideline in 2014 motivated about preventive methods. In this review, the articles published in the literature about the applied treatments the guideline in until 2018 were compiled.

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Intracranial epidural abscess secondary to medication‐related osteonecrosis of the jaw: A case report

Shibata,

Kawahara,

Ono

et al. 2024

Oral Science International

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BackgroundAn intracranial abscess secondary to medication‐related osteonecrosis of the jaw (MRONJ) is a rare condition that can spread to the skull through continuous structures.Case presentationA 71‐year‐old man with an intracranial epidural abscess caused by MRONJ in the maxilla. Because it is refractory to conservative treatment, inflammation had spread from sphenoid sinusitis, resulting in an intracranial abscess, and then antibiotic therapy and surgical drainage contributed to successful outcomes.ConclusionIntracranial abscess should be suspected when MRONJ extends to the adjacent structure, causing sudden headache and loss of consciousness. Early surgical intervention should be considered to reduce the risk of necrosis progressing.

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Brain abscess secondary to medication-induced osteonecrosis of the jaw

Cited by 5 publications

References 7 publications

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

Surgical treatment of medication‐related osteonecrosis of the upper jaw: Case series

Medication Related Osteonecrosis of Jaws and Current Treatment Modalities

Intracranial epidural abscess secondary to medication‐related osteonecrosis of the jaw: A case report

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