Brain abscess in immunocompetent patients: recent findings

Thy, Michaël; Gaudemer, Augustin; d’Humières, Camille; Sonneville, Romain

doi:10.1097/qco.0000000000000833

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Hematogenous dissemination and direct extension of an adjacent infection have been well documented for most brain abscesses 12 , which are also the most common presumed cause of PA. The adjacent infection which can extend to the pituitary include meningitis, sphenoid sinusitis, contaminated cerebral spinal uid stula, or cavernous sinus thrombophlebitis.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and early diagnosis of pituitary abscess: a review of twenty-four cases

Wang,

Xie,

et al. 2024

Preprint

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Objectives Pituitary abscess (PA) is a rare disorder and preoperative diagnosis is difficult. This study aims to better understand the clinical manifestations, early diagnosis, and appropriate treatment of PA.Methods This study enrolled 24 Chinese patients who were referred to Huashan Hospital, Fudan University, China, from June 2016 through December 2020, and diagnosed as PA. Their medical records were retrospectively analyzed.Results The most common clinical manifestations were amenorrhea (83.3%), male hypogonadism (66.7%), headache (66.7%), and visual disturbances (58.3%). Anterior pituitary hypofunction was commonly seen in 87.5% of them. Positive pathogenic detection was obtained in 33.3% of the patients through smear, culture and metagenomic next generation sequencing (mNGS) of CSF and pus. Rim enhancement on magnetic resonance imaging (MRI) and hyperintense on diffusion-weighted imaging (DWI) were revealed in 47.6% and 83.3% of our patients respectively. Most of the patients underwent transsphenoidal sinus surgery, accompanied with postoperative anti-infective and hormone replacement therapy.Conclusions In patients with symptoms associated with hypopituitarism, with typical rim enhancement on MRI and DWI hyperintense, the possibility of PA should be considered. Comprehensive pathogenic detection of CSF and pus were needed, and the application of mNGS may enhance the preoperative diagnostic rate. Anti-infection treatment is highly recommended after transsphenoidal sinus surgery.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and early diagnosis of pituitary abscess: a review of twenty-four cases

Wang,

Xie,

et al. 2024

Preprint

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“…Bacteria can invade the brain through direct dissemination or hematogenous dissemination, direct dissemination accounts for 20-60% of intracranial infections, bacteremic dissemination usually causes multiple lesions (1,10). S. intermedia is part of the normal microbiota and are found at various mucosal sites in the respiratory (11).…”

Section: Discussionmentioning

confidence: 99%

Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report

Chen

et al. 2022

Front. Neurol.

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Multifocal brain abscesses caused by invasive Streptococcus intermedia are relatively rare. Here, we present a 67-year-old male was admitted to the hospital for unconsciousness and fever. The computed tomography (CT) examination showed multiple intracranial space-occupying and “cavity-like” changes in the right lower lung. The examination of cerebrospinal fluid (CSF) was consistent with typical bacterial meningitis, CSF analyses revealed leukocytosis (10,300 × 106/L), elevated protein levels (140.39 mg/dL), decreased glucose levels (0.27 mmol/L), and normal chloride concentration level (120.2 mmol/L), however, pathogens were not detected in the cultures. Then, the CSF and sputum samples were analyzed using meta-genomic next-generation sequencing (mNGS), and S. intermedia was detected in both samples. We adjusted the use of antibiotics according to the results of mNGS in time. After anti-infective treatment, the patient achieved good treatment results in a very short time. This case highlights the mNGS can identify pathogens of brain abscess, and provide strong evidence for clinical diagnosis and treatment strategy.

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99mTc-linezolid as a radiotracer for brain abscess: Labeling, in silico docking, and biodistribution studies

El-Kawy

Ibrahim

Shweeta

et al. 2023

Applied Radiation and Isotopes

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Brain abscess in immunocompetent patients: recent findings

Cited by 3 publications

References 48 publications

Clinical characteristics and early diagnosis of pituitary abscess: a review of twenty-four cases

Clinical characteristics and early diagnosis of pituitary abscess: a review of twenty-four cases

Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report

99mTc-linezolid as a radiotracer for brain abscess: Labeling, in silico docking, and biodistribution studies

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