Brain abscess: clinical aspects of 100 patients

Tonon, Eva; Scotton, Pier Giorgio; Gallucci, Maurizio; Vaglia, A.

doi:10.1016/j.ijid.2005.04.003

Cited by 80 publications

(55 citation statements)

References 35 publications

(32 reference statements)

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“…7,8) In pediatric series, congenital heart disease remains the most common predisposing factor. (12,13) HISTORY: The natural history of brain abscess ranges from indolent to fulminant. The clinical presentation is dependent on multiple factors, including the location, size, and age of the lesion(s).…”

Section: Clinical Presentation: Racementioning

confidence: 99%

“…MRI should be performed using gadolinium, which can increase the signal intensity of the lesion on T1. (13,14) MRI can be particularly useful during the early cerebritis stage or when there is suspicion of a posterior fossa lesion or satellite lesions. [2] Moreover, unlike CT, MRI is capable of distinguishing between pyogenic and nonsuppurative lesions on diffusion-weighted imaging (DWI).On MRI, cerebritis appears as an area of low-signal intensity on T1-weighted imaging and has increased signal intensity on T2-weighted imaging.…”

Section: Physicalmentioning

confidence: 99%

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Study of Intracranial Abscess in Gandhi Medical College Bhopal From June 2010 to May 2014

Singh¹,

Shukla²,

Kumar³

2015

jemds

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A prospective and retrospective study was conducted in Hamidia hospital and Gandhi medical college Bhopal from year June 2010 to May 2014. Study included patients having intracranial abscesses. The objective was to know the incidence and prevalence, clinical features and management as well as outcome. Radiological and microbiological investigations were done. Procedures performed were lumbar puncture and intracranial abscess drainage by aspiration or craniotomy in few patients. There were total 33 patients in five years out of which 17 patients were operated and 16 were treated conservatively. Most common complication was residual abscess, meningitis and persistent hemiplegic.

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Section: Clinical Presentation: Racementioning

confidence: 99%

Section: Physicalmentioning

confidence: 99%

Study of Intracranial Abscess in Gandhi Medical College Bhopal From June 2010 to May 2014

Singh¹,

Shukla²,

Kumar³

2015

jemds

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“…Spread of the infection to the meninges may result in symptoms like the neck stiffness and seizures. Involvement of the cerebellum is observed as a most common consequence in otogenic brain abscess; the clinical symptoms seen include ataxia, dysmetria, and nystagmus [1,5].…”

Section: Clinical Manifestation Of Brain Abscessmentioning

confidence: 99%

“…Infection of the middle ear and mastoids may spread to CNS involving mostly the cerebellum and temporal lobes. Hematogenous spread of infection from primary sites to CNS like the dental infections, lung abscess, and other solid organ infections have been reported in literature [5]. Brain abscess involves four stages where, in the first stage, the bacteria invades in to the brain tissue resulting in neutrophil, astrocytes and microglial cell activation, edema, and tissue necrosis.…”

Section: Introductionmentioning

confidence: 99%

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Otogenic Brain Abscess: A Mini Review

Kandi¹

2014

Cureus

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Brain Abscess Apparent Diffusion Coefficient is Associated With Microbial Culture Yields

Toh

Siow

Wong

et al. 2021

Magnetic Resonance Imaging

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Background: Obtaining pus for microbial cultures is one of the surgical aims in patients with brain abscess. Predictors of microbial yields are necessary as they help in treatment planning. Purpose: To investigate the relationship between microbial culture yields of brain abscesses and their apparent diffusion coefficient (ADC) values and clinical characteristics. Study Type: Retrospective. Subjects: Eighty-four patients diagnosed with brain abscess by surgery and histopathology (59 with positive abscess cultures). Field Strength/Sequence: Diffusion-weighted, T2-weigthed, and contrast-enhanced T1-weighted imaging at 1.5 T and 3 T. Assessment: Contrast-enhanced T1-weighted images were co-registered to ADC maps. Three neuroradiologists determined abscess imaging characteristics (distribution, location, and ventricular rupture), and two measured abscess volumes and ADC values. Clinical characteristics collected included sex, age, fever, underlying diseases, infection sources, white blood cell count, percentage of segmented neutrophils, C-reactive protein level, regimen and duration of empirical antibiotics, and types of surgery. Statistical Tests: Interobserver differences were assessed with Fleiss kappa and intraclass correlation coefficients. The differences in clinical and imaging factors between the positive and negative culture groups were compared with Chi-square analysis or Student's t test. All factors were subjected to multivariable logistic regression analysis to assess their associations with microbial culture yields, and factors with statistical significance were evaluated with receiver operating characteristic curve analysis to assess their diagnostic performance in discriminating the two groups. Results: Mean ADC (×10 −6 mm 2 /s) of culture-negative abscesses (841 AE 173) was significantly higher (P < 0.05) than that of culture-positive abscesses (536 AE 90). On multivariable analysis, mean ADC was the only significant factor (P < 0.05) related to culture yields. With 660 as the cutoff value, the sensitivity, specificity, and accuracy of ADC for discriminating culture yields were 93.2%, 88.0%, and 91.7%, respectively. Data Conclusion: ADC could be used to discriminate between culture-positive and culture-negative abscesses. Evidence Level: 4 Technical Efficacy: Stage 2

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Brain abscess: clinical aspects of 100 patients

Abstract: With the exception of some epidemiological aspects, which varied from the literature, in spite of the improvements in diagnostic procedures and treatment, no significant changes occurred in the prognosis of patients with brain abscess.

Cited by 80 publications

References 35 publications

Study of Intracranial Abscess in Gandhi Medical College Bhopal From June 2010 to May 2014

Study of Intracranial Abscess in Gandhi Medical College Bhopal From June 2010 to May 2014

Otogenic Brain Abscess: A Mini Review

Brain Abscess Apparent Diffusion Coefficient is Associated With Microbial Culture Yields

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