“…However, from serial tumor biopsy specimens of melanoma patients receiving BRAF and MEK inhibitors as well as from in vivo experiments with MEK inhibitors, it became clear that MEK inhibitors stimulate MITF and melanocyte-lineage antigen expression and augment T cell infiltration (18,24). Furthermore, MEK inhibitors have an additional antitumor immunity effect, by inhibiting the interaction between tumor cells and "M2-like" macrophages, which does not allow the entry of effector T-cells into the tumor (25,26). These effects make very appealing the combination of MEK inhibitors with ICB even for BRAF wild-type melanoma patients.…”