Bradykinin receptor participates in doxorubicin‐induced cardiotoxicity by modulating iNOS signal pathway
Xueyan Chen,
Kerang Xie,
Xiaofei Zhang
et al.
Abstract:Doxorubicin (DOX), an effective and broad‐spectrum anthracycline antibiotic, is widely used in the treatment of numerous malignancies. However, dose‐dependent cardiotoxicity limits the clinical application of DOX, and the molecular mechanisms are still unknown. In this study, we used the BK receptor B1/B2 double‐knockout (B1B2‐/‐) mice to observe the role of BK receptor in cardiotoxicity induced by DOX and the underlying mechanisms. DOX induced myocardial injury with increased serum levels of AST, CK, and LDH,… Show more
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