Bradykinin postconditioning protects rat hippocampal neurons after restoration of spontaneous circulation following cardiac arrest via activation of the AMPK/mTOR signaling pathway

Chen, Feng; Song, Bin; Lin, Shirong; Lin, Qiang; Lin, Yu-Jia; Qian, Xin; Wang, Xiaoping; Gong, Zheng

doi:10.4103/1673-5374.337049

Cited by 3 publications

(2 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we identified 4 significantly different signaling pathways related to amino acid metabolism in the different groups, including aminoacyl-tRNA biosynthesis, beta-Alanine metabolism, the mTOR signaling pathway, and the AMPK signaling pathway. This is consistent with the findings in several studies on the pathway in mechanical asphyxia and myocardial infarction 30 – 32 . Creatine is a key regulator of energy metabolism and phosphocreatine is essential to maintain ATP levels in tissues with high energy demands 33 .…”

Section: Discussionsupporting

confidence: 93%

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Wang,

Liu,

Zhang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study differentiates myocardial infarction (MI) and strangulation death (STR) from the perspective of amino acid metabolism. In this study, MI mice model via subcutaneous injection of isoproterenol and STR mice model by neck strangulation were constructed, and were randomly divided into control (CON), STR, mild MI (MMI), and severe MI (SMI) groups. The metabolomics profiles were obtained by liquid chromatography-mass spectrometry (LC–MS)-based untargeted metabolomics. Principal component analysis, partial least squares-discriminant analysis, volcano plots, and heatmap were used for discrepancy metabolomics analysis. Pathway enrichment analysis was performed and the expression of proteins related to metabolomics was detected using immunohistochemical and western blot methods. Differential metabolites and metabolite pathways were screened. In addition, we found the expression of PPM1K was significantly reduced in the MI group, but the expression of p-mTOR and p-S6K1 were significantly increased (all P < 0.05), especially in the SMI group (P < 0.01). The expression of Cyt-C was significantly increased in each group compared with the CON group, especially in the STR group (all P < 0.01), and the expression of AMPKα1 was significantly increased in the STR group (all P < 0.01). Our study for the first time revealed significant differences in amino acid metabolism between STR and MI.

show abstract

Section: Discussionsupporting

confidence: 93%

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Wang,

Liu,

Zhang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The neuroprotective and cardioprotective roles of bradykinin in the context of CA are being studied in preclinical CA models. In the 6-minute rat asphyxia CA model, intraperitoneal injection of bradykinin (150 μg/kg) 48 hours after ROSC increased neurological function at 3 days after ROSC as assessed by NDS [ 65 ]. Bradykinin treatment increased neuronal autophagy, inhibited the expression of the brain injury marker S100β and apoptosis-related protein caspase-3 thus reducing the degree of brain injury caused by ROSC after CA which was mediated by activation of the AMP-activated protein kinase (AMPK)/mTOR signaling pathway.…”

Section: Neuroprotective Approaches In Ca-induced Brain Injurymentioning

confidence: 99%

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Marasini,

Jia

2024

J Stroke

View full text Add to dashboard Cite

With the implementation of improved bystander cardiopulmonary resuscitation techniques and public-access defibrillation, survival after out-of-hospital cardiac arrest (OHCA) has increased significantly over the years. Nevertheless, OHCA survivors have residual anoxia/reperfusion brain damage and associated neurological impairment resulting in poor quality of life. Extracorporeal membrane oxygenation or targeted temperature management has proven effective in improving post-cardiac arrest (CA) neurological outcomes, yet considering the substantial healthcare costs and resources involved, there is an urgent need for alternative treatment strategies that are crucial to alleviate brain injury and promote recovery of neurological function after CA. In this review, we searched PubMed for the latest preclinical or clinical studies (2016–2023) utilizing gas-mediated, pharmacological, or stem cell-based neuroprotective approaches after CA. Preclinical studies utilizing various gases (nitric oxide, hydrogen, hydrogen sulfide, carbon monoxide, argon, and xenon), pharmacological agents targeting specific CA-related pathophysiology, and stem cells have shown promising results in rodent and porcine models of CA. Although inhaled gases and several pharmacological agents have entered clinical trials, most have failed to demonstrate therapeutic effects in CA patients. To date, stem cell therapies have not been reported in clinical trials for CA. A relatively small number of preclinical stem-cell studies with subtle therapeutic benefits and unelucidated mechanistic explanations warrant the need for further preclinical studies including the improvement of their therapeutic potential. The current state of the field is discussed and the exciting potential of stem-cell therapy to abate neurological dysfunction following CA is highlighted.

show abstract

Transcriptomic analysis provides molecular insights into immune response of Ruditapes philippinarum under Vibrio parahaemolyticus challenge

Nie

Yin

et al. 2023

Aquaculture

View full text Add to dashboard Cite

Bradykinin postconditioning protects rat hippocampal neurons after restoration of spontaneous circulation following cardiac arrest via activation of the AMPK/mTOR signaling pathway

Cited by 3 publications

References 78 publications

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Transcriptomic analysis provides molecular insights into immune response of Ruditapes philippinarum under Vibrio parahaemolyticus challenge

Contact Info

Product

Resources

About