Bradykinin‐induced transient accumulation of inositol trisphosphate in neuron‐like cell line NG 108‐15 cells

Abstract

Studies were undertaken to further elucidate the mechanism(s) by which bradykinin-dependent phosphoinositide metabolism takes place in neuroblastoma x glioma hybrid NG108-15 cells [(1984 Neuroblastoma x glioma Bradykinin

International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences

“…BK-stimulated G␣ q -sensitive phospholipase C␤ yielding PI hydrolysis and an increase in intracellular free Ca 2ϩ has been observed in many cell types (e.g., Yano et al, 1985;Tilly et al, 1987;Fasolato et al, 1988;VoynoYasenetskaya et al, 1989;Byron et al, 1992;Derian and Moskowitz, 1986). Furthermore, BK translocation of the protein kinase C (PKC) isozymes ␣, ⑀, and has been shown in both fibroblasts (Tippmer et al, 1994) and endothelial cells (Ross and Joyner, 1997).…”

Bradykinin‐induced depolarization of primary afferent nerve terminals in the neonatal rat spinal cord in vitro

“…However, since BK binding sites are located mainly on primary afferent nerve fibres and in the dorsal horn of the spinal cord (Steranka et al, 1988) (Yano et al, 1985;Derian & Moskowitz, 1986;Thayer et al, 1988), giving rise to the formation of inositol trisphosphate (1P3), and diacylglycerol (DAG) which is the ' Author for correspondence at present address: Dept of Pharmacology, University College, Gower Street, London WC1E 6BT. endogenous activator of protein kinase C (PKC) (see Nishizuka, 1988). In the periphery, BK stimulates the peripheral terminals of nociceptive sensory neurones (Erdos, 1979;Martin et al, 1987;Dray et al, 1988b).…”

Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors

“…Several Bk derivatives are potent and specific Bk antagonists in guinea-pig ileum and rat uterus smooth muscle assays, and in the rat blood pressure kinin assay (Vavrek & Stewart, 1985a, b;. We have examined effects of these derivatives on Bk receptor binding and phosphoinositide (PI) turnover in neuroblastoma cells possessing functional Bk receptors (Snider & Richelson, 1984;Yano et al, 1985). We describe tissue specific differential agonist and antagonist activities of the Bk derivatives, suggesting a multiplicity of Bk receptors.…”