Bradykinin-Induced Increase in Total and Effective Blood Flow in Skeletal Muscle

Paldino, Rita L.; Hyman, Chester; Lenthall, Jim

doi:10.1161/01.res.11.5.847

Cited by 18 publications

(6 citation statements)

References 16 publications

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“…The implication of the work here reported, together with the earlier studies from this laboratory Paldino, Hyman & Lenthall, 1962), supports two major hypotheses relating to muscle circulation: (1) only a fraction of the total blood flow through muscle exchanges solutes with the tissue; (2) the magnitude of this effective flow is governed almost exclusively by local factors.…”

Section: Discussionsupporting

confidence: 83%

“…Our findings, as well as those of Paldino, Hyman & Lenthall (1962), suggest that locally produced dilators do not exert a general effect on all muscular vessels, but rather act predominantly on the nutritional circulation to divert the restricted flow from the shunts (Hyman & Winsor, 1959). This hypothesis would help to explain many of the paradoxes that arise in interpreting the changes in muscle circulation measured by plethysmographic techniques.…”

Section: Discussionsupporting

confidence: 51%

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Evidence for the shift of blood to the nutritive circulation during reactive hyperaemia

Ballard¹,

Fielding²,

Hyman³

1964

The Journal of Physiology

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 51%

Evidence for the shift of blood to the nutritive circulation during reactive hyperaemia

Ballard¹,

Fielding²,

Hyman³

1964

The Journal of Physiology

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“…At first glance, some discrepancies seem to exist between these results and those of Hyman et al 2 and Paldino et al 14 In the latter reports, intra-arterial infusions of methacholine, 48/80 (a histamine releaser), and bradykinin were shown to increase the clearance rate of I 131 from resting muscle concomitant with the increase in blood flow accompanying the induced vasodilatation. The explanation for the divergent results may well reside in the fact that flow was allowed to increase in their experiments, while in ours it was held constant.…”

Section: Circulation Research Volume XIV June 1964mentioning

confidence: 82%

Depression of Contractile Force of Skeletal Muscle by Intra-arterial Vasodilator Drugs

Hirvonen

Korobkin

Sonnenschein

et al. 1964

Circulation Research

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In a previous study 1 the maximum force of contraction of the intermittently stimulated gastrocnemius-soleus muscle group of the cat was shown to decrease in proportion to reduction in total blood flow through the muscle, brought about by various means. Activation of the cholinergic sympathetic vasodilator system through hypothalamic stimulation produced neither change in flow nor alteration in force of the contracting muscle; this suggested that the dilator system produced no redistribution of flow in contracting muscle similar to that observed in resting muscle. 2 As a corollary of these observations the effect on flow-force relations of the intra-arterial administration of acetylcholine and other vasodilator agents was investigated. As indicated in preliminary reports, 3 ' 4 these agents reduced muscle force even when flow was increased or unchanged. The mechanism of this effect is the subject of the present report. MethodsCats of either sex, weighing 2.0 to 3.0 kg, were anesthetized, after initial etherization, with alpha-chloralose (50 mg/kg iv), supplemented with urethane as required. After one hind leg was skinned, the artery supplying the gastrocnemius-soleus muscle group was isolated; in a few experiments the corresponding vein was isolated instead. Collateral circulation from thigh muscles was eliminated by ligating and sectioning them close to their insertions. The tibialis muscles were removed and the paw was ligated to eliminate its flow. Other details of this "isolated"

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“…46,[59][60][61] When provided intra-arterially to achieve physiologically relevant concentrations, they accelerate muscle blood flow, mediating vasodilation primarily in the PV and CV, as is observed during contractions. [62][63][64][65][66] Moreover, they increase glucose utilisation in SMT similar to a contraction stimulus. [48][49][50] Thus, both adenosine and kinins may contribute to the multifactorial metabolic control of the physiological responses of SMT during endurance exercise.…”

Section: Adjustments Of Skeletal Muscle Energy Provision By Autocrinementioning

confidence: 99%

Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis

Dietze¹,

Henriksen

2008

J Renin Angiotensin Aldosterone Syst

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Recent evidence suggests a coordinated regulation by the local renin-angiotensin system (RAS) and tissue kallikrein-kinin system (TKKS) of blood flow and substrate supply in oxidative red myofibres of skeletal muscle tissue during endurance exercise.The performance of these myofibres is dependent on the increased oxidation of substrates facilitated by augmenting nutritive blood flow and glucose uptake. Humoral factors released by the contracting fibres, such as adenosine and kinins, are suggested to be responsible for this metabolic adjustment.The considerable drain of blood volume and the enormous consumption of glucose during endurance exercise require a control mechanism for the maintenance of blood pressure (BP) and glucose homeostasis. This is achieved by the sympathetic nervous system and its subordinate RAS, which is located in the nutritive vessels and parenchyma of the red myofibres. The angiotensin-converting enzyme (ACE) is the primary enzyme responsible for kinin degradation during exercise, underscoring the important interrelationship between the RAS and the TKKS in the critical role of kinins in the multifactorial regulation of muscle bioenergetics and glucose and BP homeostasis. Importantly, overactivity of the ACE, as occurs in individuals displaying risk factors such as overweight, causes exaggerated BP response and reduced glucose disposal. If they persist over years, compensatory responses to this ACE overactivity, such as hypersecretion of insulin and compliance of the vessel walls, will inevitably be exhausted, leading ultimately to the manifestation of type 2 diabetes and hypertension. This concept also provides a unifying explanation for the beneficial effects of ACE-inhibitors and Angiotensin II receptor antagonists in the treatment of hypertension and insulin resistance.Need for control of blood pressure and glucose homeostasis during endurance exercise performance The regulation of muscle bioenergetics during exercise has been studied for more than 100 years.

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Bradykinin-Induced Increase in Total and Effective Blood Flow in Skeletal Muscle

Cited by 18 publications

References 16 publications

Evidence for the shift of blood to the nutritive circulation during reactive hyperaemia

Evidence for the shift of blood to the nutritive circulation during reactive hyperaemia

Depression of Contractile Force of Skeletal Muscle by Intra-arterial Vasodilator Drugs

Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis

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