Bradykinesia in early and advanced Parkinson's disease

Bologna, Matteo; Leodori, Giorgio; Stirpe, Paola; Paparella, Giulia; Colella, Donato; Belvisi, Daniele; Fasano, Alfonso; Fabbrini, Giovanni; Berardelli, Alfredo

doi:10.1016/j.jns.2016.08.028

Cited by 74 publications

(113 citation statements)

References 32 publications

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“…Alternatively, it is probable that the combination of hypokinesia, which reduces the overall magnitude of each finger tap, or tremor superimposed on voluntary finger movements, would result in more taps in some patients with PD. In fact, a recent investigation of finger tapping in PD patients finger tapping speed and amplitude (sequence effect) is progressively reduced in PD [52]. Unfortunately, we are unable to differentiate these two possibilities in the current study as the magnitude of finger movement during tapping was not captured.…”

Section: Discussionmentioning

confidence: 71%

Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer’s disease, and Parkinson’s disease

et al. 2018

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Section: Discussionmentioning

confidence: 71%

Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer’s disease, and Parkinson’s disease

et al. 2018

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“…SC IV included 7 parkinsonian signs that were selected from the Part III motor examination of the MDS‐UPDRS, contributing 21% (28 of 135) to the global scale. We selected finger tapping and leg agility to assess limb bradykinesia, as they have been considered reliable tests in Parkinson's disease and atypical parkinsonisms …”

Section: Methodsmentioning

confidence: 99%

“…We selected finger tapping and leg agility to assess limb bradykinesia, as they have been considered reliable tests in Parkinson's disease and atypical parkinsonisms. 17,[20][21][22] SC V for dystonia was adapted from the BFM motor scale (BFM-MS). We added 2 items for dystonic eye deviation and jaw/tongue dystonia, based on the specific characteristics of dystonia in PKAN patients.…”

Section: Motor Examinationmentioning

confidence: 99%

Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study

et al. 2017

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“…Two markers were placed on the tips of the index finger and thumb. A further three markers were placed on the hand to define a reference plane that was used to mathematically exclude possible contamination due to unwanted hand movements from repetitive finger movement recordings (Bologna et al, 2016a).…”

Section: Kinematic Assessmentmentioning

confidence: 99%

“…Bradykinesia, or slowness of movement, is one of the cardinal motor features of Parkinson's disease (PD) (Berardelli et al, 2013;Postuma et al, 2015). Objective kinematic measures show that this is also accompanied by other changes, including low amplitude (hypokinesia) and a progressive reduction in amplitude and velocity during movement repetition (decrement) (Agostino et al, 1992 andBerardelli et al, 2001;Espay et al, 2009 andKang et al, 2010;Heldman et al, 2014;Bologna et al, 2016a;Hasan et al, 2017). Bradykinesia is believed to result primarily from a failure of basal ganglia output to the primary motor cortex (M1) (Berardelli et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological correlates of bradykinesia in Parkinson’s disease

Bologna

Guerra

Paparella

et al. 2018

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Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson's disease. However, it is unclear whether there is any relationship between them and bradykinesia, one of the cardinal motor features of the condition. In the present study we aimed to investigate whether objective measures of bradykinesia in Parkinson's disease have any relationship with neurophysiological measures in primary motor cortex as assessed by means of transcranial magnetic stimulation techniques. Twenty-two patients with Parkinson's disease and 18 healthy subjects were enrolled. Objective measurements of repetitive finger tapping (amplitude, speed and decrement) were obtained using a motion analysis system. The excitability of primary motor cortex was assessed by recording the input/output curve of the motor-evoked potentials and using a conditioning-test paradigm for the assessment of short-interval intracortical inhibition and facilitation. Plasticity-like mechanisms in primary motor cortex were indexed according to the amplitude changes in motor-evoked potentials after the paired associative stimulation protocol. Patients were assessed in two sessions, i.e. OFF and ON medication. A canonical correlation analysis was used to test for relationships between the kinematic and neurophysiological variables. Patients with Parkinson's disease tapped more slowly and with smaller amplitude than normal, and displayed decrement as tapping progressed. They also had steeper input/output curves, reduced short-interval intracortical inhibition and a reduced response to the paired associative stimulation protocol. Within the patient group, bradykinesia features correlated with the slope of the input/output curve and the after-effects of the paired associative stimulation protocol. Although dopaminergic therapy improved movement kinematics as well as neurophysiological measures, there was no relationship between them. In conclusion, neurophysiological changes in primary motor cortex relate to bradykinesia in patients with Parkinson's disease, although other mechanisms sensitive to dopamine levels must also play a role.

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Bradykinesia in early and advanced Parkinson's disease

Cited by 74 publications

References 32 publications

Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer’s disease, and Parkinson’s disease

Quantitative assessment of finger tapping characteristics in mild cognitive impairment, Alzheimer’s disease, and Parkinson’s disease

Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study

Neurophysiological correlates of bradykinesia in Parkinson’s disease

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