Bradykinesia and dystonia

Paparella, Giulia; Guerra, Andrea; Galosi, Serena; Cannavacciuolo, Antonio; Angelini, Luca; Popa, Traian; Berardelli, Alfredo; Bologna, Matteo

doi:10.3389/dyst.2023.11448

Cited by 3 publications

(2 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, PTV decreased when moving with a given arm from the ipsilateral to the contralateral target, as it could be expected, due to the higher mechanical constraint affecting contralateral pointing movements. Consistently with previous investigations, its value was lower in CD patients with respect to normal participants, thus pointing to bradykinesia as a characteristic of this specific disorder ( Carboncini et al, 2004 ; Pelosin et al, 2009 ; Anastasopoulos et al, 2013 ; Nowak et al, 2013 ), in line with what it is generally observed for dystonic disturbances ( Paparella et al, 2023 ). This finding is consistent with the reduced agonist burst observed by Carboncini et al (2004) .…”

Section: Discussionsupporting

confidence: 90%

Pointing in cervical dystonia patients

Tramonti Fantozzi,

Benedetti,

Crecchi

et al. 2023

Front. Syst. Neurosci.

View full text Add to dashboard Cite

IntroductionThe normal hemispheric balance can be altered by the asymmetric sensorimotor signal elicited by Cervical Dystonia (CD), leading to motor and cognitive deficits.MethodsDirectional errors, peak velocities, movement and reaction times of pointing towards out-of-reach targets in the horizontal plane were analysed in 18 CD patients and in 11 aged-matched healthy controls.ResultsCD patients displayed a larger scatter of individual trials around the average pointing direction (variable error) than normal subjects, whatever the arm used, and the target pointed. When pointing in the left hemispace, all subjects showed a left deviation (constant error) with respect to the target position, which was significantly larger in CD patients than controls, whatever the direction of the abnormal neck torsion could be. Reaction times were larger and peak velocities lower in CD patients than controls.DiscussionDeficits in the pointing precision of CD patients may arise from a disruption of motor commands related to the sensorimotor imbalance, from a subtle increase in shoulder rigidity or from a reduced agonists activation. Their larger left bias in pointing to left targets could be due to an increased right parietal dominance, independently upon the direction of head roll/jaw rotation which expands the left space representation and/or increases left spatial attention. These deficits may potentially extend to tracking and gazing objects in the left hemispace, leading to reduced skills in spatial-dependent motor and cognitive performance.

show abstract

Section: Discussionsupporting

confidence: 90%

Pointing in cervical dystonia patients

Tramonti Fantozzi,

Benedetti,

Crecchi

et al. 2023

Front. Syst. Neurosci.

View full text Add to dashboard Cite

show abstract

“…From a pathophysiological point of view, DT seems closer to nontremulous dystonia than ET ( Panyakaew et al, 2022 ). Based on a recent review article by Paparella et al, bradykinesia is frequently observed in dystonia involving basal ganglia, primary sensorimotor cortex and cerebellum in the pathological mechanism ( Paparella et al, 2023 ). Mild parkinsonian signs are an additional manifestation of dystonia arising mainly from the already mentioned basal ganglia dysfunction ( Haggstrom et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Bradykinesia in dystonic hand tremor: kinematic analysis and clinical rating

Matejicka,

Kajan,

Goga

et al. 2024

Front. Hum. Neurosci.

View full text Add to dashboard Cite

IntroductionBradykinesia is an essential diagnostic criterion for Parkinson’s disease (PD) but is frequently observed in many non-parkinsonian movement disorders, complicating differential diagnosis, particularly in disorders featuring tremors. The presence of bradykinetic features in the subset of dystonic tremors (DT), either “pure” dystonic tremors or tremors associated with dystonia, remains currently unexplored. The aim of the current study was to evaluate upper limb bradykinesia in DT patients, comparing them with healthy controls (HC) and patients with PD by observing repetitive finger tapping (FT).MethodsThe protocol consisted of two main parts. Initially, the kinematic recording of repetitive FT was performed using optical hand tracking system (Leap Motion Controller). The values of amplitude, amplitude decrement, frequency, frequency decrement, speed, acceleration and number of halts of FT were calculated. Subsequently, three independent movement disorder specialists from different movement disorders centres, blinded to the diagnosis, rated the presence of FT bradykinesia based on video recordings.ResultsThirty-six subjects participated in the study (12 DT, 12 HC and 12 early-stage PD). Kinematic analysis revealed no significant difference in the selected parameters of FT bradykinesia between DT patients and HC. In comparisons between DT and PD patients, PD patients exhibited bigger amplitude decrement and slower FT performance. In the blinded clinical assessment, bradykinesia was rated, on average, as being present in 41.6% of DT patients, 27.7% of HC, and 91.7% of PD patients. While overall inter-rater agreement was moderate, weak agreement was noted within the DT group.DiscussionClinical ratings indicated signs of bradykinesia in almost half of DT patients. The objective kinematic analysis confirmed comparable parameters between DT and HC individuals, with more pronounced abnormalities in PD across various kinematic parameters. Interpretation of bradykinesia signs in tremor patients with DT should be approached cautiously and objective motion analysis might complement the diagnostic process and serve as a decision support system in the choice of clinical entities.

show abstract