Brachytherapy—Interstitial Implant Radiosurgery

Ostertag, Christoph B.

doi:10.1007/978-3-7091-9297-9_18

Cited by 15 publications

(8 citation statements)

References 14 publications

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“…Characteristic tissue effects associated with the high dose zone in the vicinity of the implanted source (≥ 200Gy) have been described experimentally, i. e. the development of circumscribed radionecrosis with temporary changes in capillary permeability with a sometimes extensive oedema and concomitantly reduced regional cerebral blood flow [18-20,55,56] (see below).…”

Section: Reviewmentioning

confidence: 99%

Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined.An extensive review of the literature has been performed, especially concerning indications, results and complications. Iodine-125 seeds have been implanted in astrocytomas I-III, glioblastomas, metastases and several other tumour entities. Outcome data given in the literature are summarized. Complications are rare in carefully selected patients.All in all, for highly selected patients with newly diagnosed or recurrent primary or metastatic tumours, this method provides encouraging survival rates with relatively low complication rates and a good quality of life.

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Section: Reviewmentioning

confidence: 99%

Iodine-125 brachytherapy for brain tumours - a review

et al. 2012

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“…This is a clear advantage over open microsurgery, which carries a serious risk of permanent neurologic and endocrine sequelae. 6 This increases the therapeutic ratio and allows for repeated seed implantations if the initial effect is incomplete. The principle of interstitial radiosurgery may be advantageous in avoiding potential radiation-induced side effects as the application of gamma radiation from the center of the lesion can be performed with minimal exposition of extralesional brain tissue to gamma radiation (see figure 1).…”

Section: Resultsmentioning

confidence: 99%

Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas

Schulze-Bonhage¹,

Homberg²,

Trippel³

et al. 2004

Neurology

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The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients had become seizure-free within 2 months, and two others had only persisting auras. There were no major perioperative or postoperative side effects.

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“…Considerable data exist for brachytherapeutic treatment of low-grade gliomas (WHO I pilocytic astrocytomas, WHO II astrocytomas, oligoastrocystomas and oligodendrogliomas), both in children and adults (Julow et al, 2007;Korinthenberg et al, 2010;Kreth et al, 1995;Mehrkens et al, 2004;Mundinger et al, 1991;Ostertag et al, 1993;Ruge et al, 2011a;Schatz et al, 1994;Suchorska et al, 2011).…”

Section: Sbt For Low-grade Gliomas (Who I and Ii)mentioning

confidence: 99%