Brachytherapy for prostate cancer

Porter, Arthur T.; Blasko, John C.; Grimm, Peter; Reddy, Sunil; Ragde, Haakon

doi:10.3322/canjclin.45.3.165

Cited by 84 publications

(31 citation statements)

References 56 publications

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“…Louis Pasteur suggested that surgical insertion of radium seed into the prostate may eradicate this malignancy [3]. A number of techniques were subsequently used with limited success.…”

Section: Historical Backgroundmentioning

confidence: 99%

Development of Miniature 125I - Seeds for the Treatment of Prostate Cancer

Saxena¹,

Dash²

2011

Prostate Cancer - Original Scientific Reports and Case Studies

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“…Louis Pasteur suggested that surgical insertion of radium seed into the prostate may eradicate this malignancy [3]. A number of techniques were subsequently used with limited success.…”

Section: Historical Backgroundmentioning

confidence: 99%

Development of Miniature 125I - Seeds for the Treatment of Prostate Cancer

Saxena¹,

Dash²

2011

Prostate Cancer - Original Scientific Reports and Case Studies

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“…[1] Because the radioactive seeds are implanted into the tumor, the dose is internally deposited and thus the damage to the normal tissues around the tumor can be reduced without sacrificing the high treatment efficacy. However, because the implantation requires a manual operation, there is a risk of surgical staff being exposed to radiation during the procedure.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the X‐ray distribution of a syringe‐needle type proton‐induced X‐ray source by Geant4 simulation

Fukuda

Oguri

2017

X-Ray Spectrometry

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The accelerator-based syringe needle-type proton-induced X-ray source, which was proposed by the authors in 2013 as an alternative for prostate cancer brachytherapy, has an essential issue in that its dose distribution is affected by many factors, such as the structure of the needle and incident proton beam conditions. In this paper, as a method of evaluating dose distribution, we propose a Geant4 simulation to study the effect of the incident proton beam condition on the spectrum and distribution of X-ray emission, using experimentally measured proton beam emittance as input data. The results showed that the effect of beam misalignment was significant and confirmed the effectiveness of this method. It is expected that improving this method will clarify the other factors that affect X-ray distribution, so that finally, we can optimize such factors in designing a special dose distribution for the irradiation of tumors of arbitrary size and shape in the tissue.

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“…1 In the context of localised prostate cancer, permanent prostate brachytherapy (PPB) is now an established procedure alongside external beam radiotherapy and radical prostatectomy as a valid curative modality, with recent follow-up data showing equivalent results. [2][3][4] It is interesting to note, however, that prostate brachytherapy actually outdates the retropubic radical prostatectomy by several decades.…”

Section: Introductionmentioning

confidence: 99%

Permanent prostate brachytherapy: a century of technical evolution

Acher

Morris

Popert

et al. 2006

Prostate Cancer Prostatic Dis

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Purpose: To summarise the practical aspects of the development of techniques of interstitial permanent prostate brachytherapy (PPB) implantation. Prostate brachytherapy dates back to Pasteau's publication in 1913 describing the insertion of a radium capsule into the prostatic urethra to treat carcinoma of the prostate. Various implantation methods were employed but with unsatisfactory results until the development of the transrectal ultrasound in the 1980s. The subsequent two-stage Seattle technique allowed for a planned homogenous distribution of radioactive sources throughout the gland resulting in biochemical control comparable to surgical and external beam radiotherapy series. With the advent of advanced computer software and improved imaging, the technique has developed accordingly to a single stage procedure with ontable dosimetric assessment. The principles of targeting dose to the prostate while avoiding surrounding organs at risk remain as relevant today as nearly a century ago. There is an array of techniques to consider for the novice PPB provider. Whether the evolution of PPB techniques will translate into improved biochemical control is yet to be seen.

show abstract

Brachytherapy for prostate cancer

Cited by 84 publications

References 56 publications

Development of Miniature 125I - Seeds for the Treatment of Prostate Cancer

Development of Miniature 125I - Seeds for the Treatment of Prostate Cancer

Evaluation of the X‐ray distribution of a syringe‐needle type proton‐induced X‐ray source by Geant4 simulation

Permanent prostate brachytherapy: a century of technical evolution

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