Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum

Zou, Zhen‐Xing; Tan, Gui‐Shan; Huang, Qi; Sun, Huihui; Huo, Luqiong; Zhong, Wan-Qi; Zhao, Liyun; Liu, Hongxin; Tan, Haibo

doi:10.1016/j.fitote.2018.08.026

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…Thus, R. tomentosa could prevent microbial deterioration and extend food shelf life as a biocontrol agent and natural preservative (Zhao et al 2019). Meroterpenoid compounds have been isolated and identified from various other Myrtaceae species, including Eucalyptus tereticornis (Liu et al 2018) and Leptospermum brachyandrum (Zou et al 2018). Belwal et al (2019) reported that flavonoid content declined throughout fruit ripening in Rubus ellipticus, Myrica esculenta, Prunus persica, blueberry (Vaccinium corymbosum), and blackberry fruit, as did Lin et al (2020) in blueberries.…”

Section: Discussionmentioning

confidence: 99%

The morphoanatomy, histochemistry, and phytochemistry of the leaves and fruits of Rhodomyrtus tomentosa

2023

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Abstract. Kuntorini EM, Sari SG, Fariani R. 2023. The morphoanatomy, histochemistry, and phytochemistry of the leaves and fruits of Rhodomyrtus tomentosa. Biodiversitas 24: 98-105. Rhodomyrtus tomentosa (Ait.) Hassk is native to Southeast Asia. The entire plant has been used in traditional Vietnamese, Chinese, and Malaysian medicine for a long time. Bioactive substances are abundant in ripe fruits. However, few studies have examined phytochemical changes and distribution throughout leaf and fruit growth. This study evaluated the morphoanatomy, histochemical, and phytochemical properties of R. tomentosa leaves and fruits. The cross-sectional anatomical structures observed in the leaves included the epidermis, mesophyll, and carrier bundle, while the fruit structures observed included a pericarp layer with an exocarp/outer layer, mesocarp, and endocarp. Flavonoids, tannins, terpenoids, and alkaloids were found in the leaf's adaxial and abaxial epidermis, mesophyll, xylem, phloem, midrib parenchyma, secretory cavities, and trichomes. They were also distributed throughout the fruit's exocarp, mesocarp, endocarp, secretory cavities, xylem, phloem, trichomes, and seeds. Young leaves contained the highest total flavonoid concentration (196 ± 1.77 mg QE/g), green fruit had the highest total phenol concentration (97.70 ± 18.15 mg GAE/g), old leaves contained the highest total alkaloid concentration (13.22 ± 0.98%), and red fruit had the highest total tannin concentration (1.66 ± 0.15 mg GAE/g).

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Section: Discussionmentioning

confidence: 99%

The morphoanatomy, histochemistry, and phytochemistry of the leaves and fruits of Rhodomyrtus tomentosa

2023

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“…The structural diversity of mono-or sesquiterpenes instills chemical structures to this type of meroterpenoids. Not only from R. tomentosa, but also from other plants of the Myrtaceae family including Eucalyptus tereticornis , Leptospermum brachyandrum (Zou et al, 2018) and Callistemon rigidus (Cao et al, 2018), meroterpenoids have been isolated and identified. Specially, the chiral carbons are common at the structure of meroterpenoids in R. tomentosa, and the isobutyl group can be frequently seen as the terminal group of the compounds (86-89, 93-97 and 99-102).…”

Section: Meroterpenoidsmentioning

confidence: 99%

Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Zhao

Xie

et al. 2020

Food Chemistry

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Rhodomyrtus tomentosa (Aiton) is a flowering plant native to southern and southeastern Asia.Up to date, 106 chemical constituents have been isolated and identified from R. tomentosa. Among these compounds, triterpenoids, flavonoids, phenols and meroterpenoids are the major constituents. Investigations of pharmacological activities of R. tomentosa revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including antibacterial, antitumor, anti-inflammatory and antioxidant activities both in vivo and in vitro. The purpose of this review is to provide an overview of R. tomentosa studies until 2019. This article also intends to review advances in the botanical, phytochemical, pharmacological studies and industrial applications of R. tomentosa, which will provide a useful bibliography for further investigations and applications of R. tomentosa in medicines and foods.

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“…Leptospermum brachyandrum, introduced to China decades ago, has been widely cultivated in the south of China due to its ornamental and medicinal values [11]. Our previous phytochemical investigation of Leptospermum brachyandrum resulted in the isolation of 2 pinene-derived meroterpenoids and 1 phloroglucinol derivative [12]. As part of our program to discover more structurally complex and biologically active secondary metabolites from medicinal plant-derived fungi, Rhytidhysteron sp.…”

Section: Introductionmentioning

confidence: 99%

Rhytidhyesters A – D, 4 New Chlorinated Cyclopentene Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9

et al. 2021

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Four new chlorinated cyclopentene derivatives, rhytidhyesters A – D (1 – 4), were isolated from Rhytidhysteron sp. BZM-9, an endophytic fungus from Leptospermum brachyandrum. The planar structures of compounds 1 – 4 were mainly elucidated by 1D, 2D NMR, and HRESIMS data. Their absolute configurations were established by X-ray crystallographic analysis, quantum chemical 13C NMR, and electronic circular dichroism calculations. Compounds 1 and 2 are a pair of epimers. Moreover, all the isolated compounds were evaluated for cytotoxic activities against 3 human colon cancer cell lines (SW620, HT29, SW480) and antimicrobial activity against Staphylococcus aureus. All compounds exhibited weak to moderate antiproliferative activities with IC50 values ranging from 15.4 to 37.7 µM but were inactive against S. aureus.

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Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum

Cited by 9 publications

References 20 publications

The morphoanatomy, histochemistry, and phytochemistry of the leaves and fruits of Rhodomyrtus tomentosa

The morphoanatomy, histochemistry, and phytochemistry of the leaves and fruits of Rhodomyrtus tomentosa

Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Rhytidhyesters A – D, 4 New Chlorinated Cyclopentene Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9

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