Brachial plexopathy associated with interleukin‐2 therapy

Loh, Frank L.; Herskovitz, Steven; Berger, Alan R.; Swerdlow, Michael

doi:10.1212/wnl.42.2.462

Cited by 29 publications

(20 citation statements)

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“…A postmortem based study showed widespread demyelination 43. A focal immune mediated mechanism of demyelination has been postulated in interleukin-2 associated brachial plexopathy 44. Immune complex formation has also been implicated as a cause of acute brachial plexus neuropathy and the Guillain-Barré syndrome associated with serum sickness 45.…”

Section: Discussionmentioning

confidence: 99%

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Mills

1999

Journal of Neurology, Neurosurgery & Psychiatry

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Objective-To determine the presence and role of proximal conduction block in neuralgic amyotrophy. Methods-Percutaneous electrical stimulation of cervical roots and brachial plexus was employed in eight patients with neuralgic amyotrophy. Root to Erb's point compound muscle action potential amplitude ratios for abductor digiti minimi, extensor digitorum communis, biceps, and deltoid muscles were compared with results obtained from 10 healthy controls. Results-Conduction block in the nerve to one muscle was found in three of eight patients (38%) suggesting focal proximal demyelination. Repeat studies showed axonal degeneration, resolution, and persistence of conduction block in these three patients respectively. Conclusion-Focal conduction block plays a significant part in the pathogenesis of neuralgic amyotrophy, which is generally regarded as an axon loss process. Therapeutic intervention should be directed to patients with persistent conduction block, with the aim of eradicating the block and possibly minimising subsequent axon loss. (J Neurol Neurosurg Psychiatry 1999;66:586-590)

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Section: Discussionmentioning

confidence: 99%

Motor root conduction in neuralgic amyotrophy: evidence of proximal conduction block

Mills

1999

Journal of Neurology, Neurosurgery & Psychiatry

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“…Association has been described with preceeding viral infections or vaccination (especially tetanus) 4,5 and with the use of immunomodulating agents such as interleukin-2 (IL-2) and interferon therapy. 6,7 Histological studies of the affected nerves of six patients demonstrate T lymphocyte-predominant chronic inflammatory infiltrates with lymphoid germinal centres and onion-bulb formation. 3,8 It has been proposed that cell-mediated immune demyelination, similar to that seen when leuco-encephalopathy develops as a complication of IL-2 therapy, may be the mechanism.…”

Section: Discussionmentioning

confidence: 97%

“…Association has been described with preceeding viral infections or vaccination (especially tetanus) 4,5 and with the use of immunomodulating agents such as interleukin‐2 (IL‐2) and interferon therapy. 6,7 …”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance imaging features of subacute idiopathic brachial neuritis

Dill-Macky¹,

Song²,

Silbert

2000

Australasian Radiology

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“…Painful brachial plexopathy has been described (Loh et al, 1992), similar to the case of neuralgic amyotrophy caused by interferon treatment, as described by Bernsen et al (1988). Painful brachial plexopathy has been described (Loh et al, 1992), similar to the case of neuralgic amyotrophy caused by interferon treatment, as described by Bernsen et al (1988).…”

Section: Interleukin-2mentioning

confidence: 89%