Brachial-Ankle Pulse Wave Velocity Mediates the Association between Increased Age and Risk of Sarcopenia among Chinese Patients with Type 2 Diabetes Mellitus

Jiang, Jiahong; Zhang, Ping; Zhou, Zijun; Xu, Zeru; Hu, Xiang; Wang, Yu; Jiang, Fei-Fei; Pan, Yang; Wang, Fei; Hong, Jing; Ye, Tingting; Xu, Ke; Zhu, Hong

doi:10.1155/2023/3786342

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…Higher brachia‐ankle PWV significantly correlates with physical frailty in older adults 82 . A recent study suggested that the ankle‐brachial PWV might be responsible for the association between aging and sarcopenia risk 83 . Low ABI similarly exhibits an association with poor functional status in the hospitalized older patients 84 …”

Section: Vascular Frailty: How To Operationalize?mentioning

confidence: 99%

Vascular frailty, a proposal for new frailty type: A narrative review

Chao

Hung

2023

The Kaohsiung J of Med Scie

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Frailty is the incremental accumulation of minute defects that progressively impair health and performance. Frailty is commonly observed in older adults; however, secondary frailty may also occur in patients with metabolic disorders or major organ failure. In addition to physical frailty, several distinct types of frailty have been identified, including oral, cognitive, and social frailty, each of which is of practical importance. This nomenclature suggests that detailed descriptions of frailty can potentially advance relevant researches. In this narrative review, we first summarize the clinical value and plausible biological origin of frailty, as well as how to appropriately assess it using physical frailty phenotypes and frailty indexes. In the second part, we discuss the issue of vascular tissue as a relatively underappreciated organ whose pathologies contribute to the development of physical frailty. Moreover, when vascular tissue undergoes degeneration, it exhibits vulnerability to subtle injuries and manifests a unique phenotype amenable to clinical assessment prior to or accompanying physical frailty development. Finally, we propose that vascular frailty, based on an extensive set of experimental and clinical evidence, can be considered a new frailty type that requires our attention. We also outline potential methods for the operationalization of vascular frailty. Further studies are required to validate our claim and sharpen the spectrum of this degenerative phenotype.

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Section: Vascular Frailty: How To Operationalize?mentioning

confidence: 99%