BPA promotes lung fibrosis in mice by regulating autophagy-dependent ferroptosis in alveolar epithelial cells

Liang, Ni; Song, Wenyi; Li, Jing

doi:10.1016/j.ecoenv.2024.116412

Cited by 2 publications

(1 citation statement)

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“…( 148 ) reported that a reduction in GPX4 levels, achieved through the transfection of GPX4 siRNA into the human corneal epithelial cell line HCEC, could lead to an increase in lipid peroxidation products such as lactate dehydrogenase (LDH) and 4-hydroxynonenal (4-HNE), thus triggering ferroptosis. Furthermore, the application of Fer-1, an inhibitor of ferroptosis, was found to mitigate cellular damage associated with the knockout of the GPX4 gene ( 229 ). Additional studies have indicated that mice with partial knockout of GPX4 exhibit slower corneal wound healing after epithelial injury than their wild-type counterparts, underscoring the significance of GPX4 in the repair process following corneal injury.…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%