Boztas

Boztas, Sevinc

doi:10.4274/sevincboztas

Cited by 1 publication

(2 citation statements)

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“…66 Non-bonded force parameters were taken directly from previous studies, 66 where the balance of hydrophobic and hydrophilic interactions has been well justified. All interactions in DPD are defined in Equations (1)- (5). All self-assembly simulations were performed with Lammps.…”

Section: Methodsmentioning

confidence: 99%

“…The administration of these poorly soluble bioactive agents usually requires a vehicle or carrier, facilitating improved dispersion, selectivity, and activity. [1][2][3][4][5] Prodrugs are often designed to improve bioavailability of an active drug, and to improve its selective interaction with desired cells via site specific triggerability. [6][7][8][9][10] Triggerable pro-drugs ensure that even their entry to offtarget cells do not cause any adverse effect.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pro-Nifuroxazide Self-Assembly Leads to Triggerable Nanomedicine for Anti-cancer Therapy

Misra

Wu²,

Ostadhossein

et al. 2019

ACS Appl. Mater. Interfaces

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Transcription factor STAT3 has been shown to regulate genes that are involved in stem cell selfrenewal and thus represents a novel therapeutic target of great biological significance. However, many small molecule agents with potential effects in cancer therapy lack aqueous solubility and high off-target toxicity, hence impeding efficient bioavailability and activity. This work, for the first time, reports a prodrug-based strategy for selective and safer delivery of STAT3 inhibitors designed towards metastatic and drug resistant breast cancer. We have synthesized a novel lipaselabile SN-2 phospholipids-pro-drug from a clinically investigated STAT3 inhibitor, nifuroxazide (Pro-nifuroxazide), which can be regioselectively cleaved by the membrane abundant enzymes in *

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Section: Methodsmentioning

confidence: 99%