Boys with a Simple Delayed Puberty Reach Their Target Height

Cools, Björn; Rooman, Raoul; Beeck, L. Op De; Caju, M. V. L. Du

doi:10.1159/000137663

Cited by 20 publications

(8 citation statements)

References 48 publications

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“…Applying the same means for determining AHt in children with growth disorders may yield inaccurate results [30]. The classic prediction method of Bayley and Pinneau [4], using the tables of ‘average’ or ‘retarded’ children for predicting AHt of short children with constitutional delay of growth and puberty [31], or of children born small for gestational age [32], tended to overestimate AHt. In constitutional tall stature, tables of ‘average’ or ‘accelerated’ children tended either to underestimate or overestimate AHt [33].…”

Section: Discussionmentioning

confidence: 99%

Natural History of Idiopathic Advanced Bone Age Diagnosed in Childhood: Pattern of Growth and Puberty

et al. 2010

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Background: Significant idiopathic bone age (BA) advancement is defined as BA >2 SD above the mean chronological age (CA) with no underlying etiology. BA advancement due to endocrinopathies is associated with early puberty and compromised adult height (AHt), necessitating treatment. The natural history of idiopathic BA advancement is not well-established. Aim: To determine the pattern of growth and puberty, and validity of AHt prediction in idiopathic BA advancement. Methods: Fifty-five prepubertal patients (20 boys aged 6.7 ± 2.2 years, 35 girls aged 6.4 ± 2.0 years) evaluated between 1985 and 2008 were found to have idiopathic BA advancement. Assessed during follow-up were: BA, height (Ht), weight (Wt), pubertal course and predicted AHt (PAHt). Attained AHt was compared to PAHt and to midparental Ht (MPHt). Results: Throughout follow-up, BA-SDS (SD score) significantly declined (p < 0.001), Ht-SDS significantly decreased (p = 0.006) and Wt-SDS did not change. Pubertal onset, duration and growth were within the normal range. Attained AHts did not differ significantly from MPHts (boys: 172 ± 6.7 vs. 171 ± 6.1 cm; girls: 160.5 ± 6.5 vs. 159.0 ± 6.8 cm). PAHts using the ‘accelerated’ tables of Bayley and Pinneau were accurate. Conclusion: Idiopathic BA advancement differs from BA advancement with underlying endocrinopathy in evolution of BA progression (decline in BA-SDS), growth pattern, validity of AHt prediction and uncompromised AHt. This indicates that it requires minimal clinical monitoring and usually does not mandate treatment.

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Section: Discussionmentioning

confidence: 99%

Natural History of Idiopathic Advanced Bone Age Diagnosed in Childhood: Pattern of Growth and Puberty

et al. 2010

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“…These athletes often present in later life with bone-related problems that are exacerbated if excessive training occurred during adolescence and development [6]. The effects of hypogonadism in males are equivocal [7, 8] and to a large extent depend upon the age at which hypogonadism occurred. A delay in puberty may result in slower rates of peak bone growth with a result that these males may fail to reach their genetic target height and have shorter stature than expected [8].…”

Section: Introductionmentioning

confidence: 99%

Lack of sexual dimorphism in femora of the eusocial and hypogonadic naked mole-rat: A novel animal model for the study of delayed puberty on the skeletal system

Pinto

Jepsen

Terranova

et al. 2010

Bone

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Sex steroid hormones are major determinants of bone morphology and quality and are responsible for sexually dimorphic skeletal traits. Hypogonadism results in suboptimal skeletal development and may lead to an increased risk of bone fracture later in life. The etiology of delayed puberty and/or hypothalamic amenorrhea is poorly understood, and experimental animal models addressing this issue are predominantly based upon short-term experimental induction of hormonal suppression via gonadotropin releasing hormone antagonists (GnRH-a). This acute change in hormone profile does not necessarily emulate the natural progression of hypogonadic bone disorders. We propose a novel animal model with which to explore the effects of chronic hypogonadism on bone quality, the naked mole-rat (NMR; Heterocephalus glaber). This mouse-size rodent may remain reproductively suppressed throughout its life, if it remains as a subordinate within the eusocial mole-rat colony. NMRs live in large colonies with a single dominant breeding female. She, primarily by using aggressive social contact, naturally suppresses the hypothalamic gonadotropic axis of subordinate NMRs and thereby their reproductive expression. However should an NMR be separated from the dominant breeder, within less than a week reproductive hormones may become elevated and the animal attains breeding status. We questioned if sexual suppression of subordinates impact upon the development and maintenance of the femora, and lead to a sexually indistinct monomorphic skeleton. Femora were obtained from male and female NMRs that were either non-breeders (subordinate) or breeders at the time of sacrifice. Diaphyseal cross-sectional morphology, metaphyseal trabecular micro-architecture and tissue mineral density of the femur was measured using MicroComputed tomography and diaphyseal mechanical properties were assessed by four-point bending tests to failure. Subordinates were sexually monomorphic and showed no significant differences in body weight or femoral bone structure and quality between male and females. Femora of subordinate females differed significantly from that of breeding animals, whereas in males, the divergent trend among breeders and non-breeders did not reach statistical significance. Subordinate NMRs, naturally suppressed from entering puberty, may prove to be a useful model to tease apart the relationship between bone morphology and hypogonadism and evaluate skeletal development during pubertal maturation.

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“…Body proportions vary in relation to maturational tempo, which could provide insights into this pattern of findings. Since more leg growth generally occurs prior to puberty, while trunk growth is fastest during the pubertal growth phase, individuals who reach puberty earlier tend to have shorter relative leg length and a longer relative trunk length (Cools, Rooman, Op De Beeck, & Du Caju, ; Gunnell, Smith, Frankel, Kemp, & Peters, ; Nielsen et al, ; Schooling et al, ; Wadsworth, Hardy, Paul, Marshall, & Cole, ; Schooling et al, ). As such, the associations present in the Cebu cohort might be due to fathers who transitioned into puberty earlier, and who could have started experiencing the PAC effect on their sperm TL at an earlier age as a result, passing on longer telomeres to offspring.…”

Section: Discussionmentioning

confidence: 99%

Testing for paternal influences on offspring telomere length in a human cohort in the Philippines

Eisenberg

Rej

Duazo

et al. 2019

American J Phys Anthropol

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Objectives: Telomeres, emerging biomarkers of aging, are comprised of DNA repeats located at chromosomal ends that shorten with cellular replication and age in most human tissues. In contrast, spermatocyte telomeres lengthen with age. These changes in telomere length (TL) appear to be heritable, as older paternal ages of conception (PAC) predict longer offspring TL. Mouse-model studies raise questions about the potential for effects of paternal experiences on human offspring TL, as they suggest that smoking, inflammation, DNA damage, and stressors all shorten sperm TL. Here, we examined whether factors from the paternal environment predict offspring TL as well as interact with PAC to predict offspring TL.Materials and Methods: Using data from the Philippines, we tested if smoking, psychosocial stressors, or shorter knee height (a measure of early life adversity) predict shorter offspring TL. We also tested if these interacted with PAC in predicting offspring TL.Results: While we did not find the predicted associations, we observed a trend toward fathers with shorter knee height having offspring with longer TL. In addition, we found that knee height interacted with PAC to predict offspring TL. Specifically, fathers with shorter knee heights showed a stronger positive effect of PAC on offspring TL.Discussion: While the reasons for these associations remain uncertain, shorter knee height is characteristic of earlier puberty. Since spermatocyte TL increases with the production of sperm, we speculate that individuals with earlier puberty, and its concomitant commencement of production of sperm, had more time to accumulate longer sperm telomeres. K E Y W O R D Sepigenetics, intergenerational effects, intergenerational inertia, intergenerational plasticity, senescence

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Boys with a Simple Delayed Puberty Reach Their Target Height

Cited by 20 publications

References 48 publications

Natural History of Idiopathic Advanced Bone Age Diagnosed in Childhood: Pattern of Growth and Puberty

Natural History of Idiopathic Advanced Bone Age Diagnosed in Childhood: Pattern of Growth and Puberty

Lack of sexual dimorphism in femora of the eusocial and hypogonadic naked mole-rat: A novel animal model for the study of delayed puberty on the skeletal system

Testing for paternal influences on offspring telomere length in a human cohort in the Philippines

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