Box-Behnken Design for Optimization of Formulation Variables for Controlled Release Gastroretentive Tablet of Verapamil Hydrochloride

ARPNA, INDURKHYA; MASHEER, KHAN AHMED

doi:10.22159/ijap.2023v15i1.46489

Cited by 4 publications

(4 citation statements)

References 23 publications

(27 reference statements)

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“…The mathematical model is optimized using Design-Expert 12's optimization module [34][35][36] . The best seed guiding device performance parameters are: a qualified rate of 98.49%, repeated sowing rate of 0.48%, missed sowing rate of 1.03%, and coefficient of variation of 1.03% when the number of seed cavity intervals between adjacent seeds is 5.16, the installation angle is 79.40, and the height from the ground is 31.84 mm.…”

Section: Optimization and Verification Of Resultsmentioning

confidence: 99%

Design and optimization of the seed conveying system for belt-type high-speed corn seed guiding device

Yifei,

Wenqi,

Chengcheng

et al. 2024

International Journal of Agricultural and Biological Engineering

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Seeding is an important part of improving corn yield. Currently, seed guide tubes are mostly used as transport devices. But the existing seed guide tubes cannot meet the requirements or achieve the goal of fixing the seed falling trajectory. A seed collision phenomenon occurs occasionally. So, in response to the problems that the seeds and seed guide tube collide or bounce under high speed operation, which results in a lower sowing qualification rate and poor spacing uniformity, a seed receiving and conveying system comprising a belt-type high-speed corn seed guiding device was designed and optimized, to meet the needs of high-speed precision sowing operations and improve the spacing uniformity.The factors affecting the seed conveying performance were obtained by analyzing the mechanical properties of the seeds at various movement stages. These factors were the number of seed cavities between adjacent seeds, the forward speed, the height from the ground, and the installation angle. Single factor simulation experiments were conducted by selecting the paddle spacing as the test factor and using the pass rate, reseeding rate, omission rate and coefficient of variation as the evaluation indexes to investigate the influence of the paddle spacing on the seed guide performance of the device and further determine the structural parameters of the paddle belt. Orthogonal rotation combination tests of three factors and five levels were also conducted through bench testing.Then the test outcomes were optimized. The results indicated that the best results were obtained when the number of seed cavity intervals between adjacent seeds was 5.16, the installation angle was 79.40°, and the height from the ground was 31.84 mm. At this time, the qualified rate was 98.49%, the repeated sowing rate was 0.48%, the missed sowing rate was 1.03%, and the coefficient of variation was 6.80%. Experiments were used to validate the optimization results, and all of the obtained index data satisfied the criteria for accurate and quick corn sowing. The study's findings can serve as a theoretical foundation for a belt-type high-speed corn seed guiding device optimization test.

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Section: Optimization and Verification Of Resultsmentioning

confidence: 99%

Design and optimization of the seed conveying system for belt-type high-speed corn seed guiding device

Yifei,

Wenqi,

Chengcheng

et al. 2024

International Journal of Agricultural and Biological Engineering

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“…Over the course of a three month, we kept the sample at three different temperatures and humidity levels: room temperature, refrigerator temperature, and 37 °C (relative humidity = 75%). After 1, 2 and 3 mo, the entrapment efficiency, mucoadhesion, drug content and visual changes of the optimised batch F13 were assessed [23][24][25][26][27][28][29].…”

Section: Stability Studiesmentioning

confidence: 99%

“…Increase concentration of chitosan from 1.0-2.0 mg/ml decrease mucoadhesion but beyond 2.0 mg conc. Mucoadhesion increases [24].…”

Section: Effect Of Formulation Variables On Mucoadhesive Forcementioning

confidence: 99%

Formulation and Development of Mucoadhesive Nasal Drug Delivery of Ropinirol HCL for Brain Targeting

SONAWANE,

JAWALE,

DEVHADRAO

et al. 2023

Int J App Pharm

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Objective: The purpose of this research was to create polymeric nanoparticles of ropinirole HCl for nasal administration utilising the ionic gelation process. Methods: The preparation method was optimized using box-behnken design employing chitosan concentration, guar gum concentration and surfactant concentration as independent variables were as Encapsulation efficiency and mucoadhesion of the formulation were selected as dependent variables. Differential scanning calorimetry and infrared spectroscopy analysis of the drug and polymers revealed that the drug and excipients are physicochemically compatible. Studies on entrapment efficiency, drug content, and In vitro release were conducted on the nanoparticles. Results: Each formulation was determined to have a drug content of between 60% and 70% and an entrapment efficiency of between 65% and 84%. In vitro drug release tests demonstrated that ropinirole HCl will release between 65 and 81 percent after 5 h. Conclusion: The results showed that the particle size, encapsulation effectiveness, and drug content were all significantly affected by the amounts of chitosan and guar gum.

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“…The computer-aided optimization of SA-loaded liposomes was done by Design Expert trial version software (Stat-Ease Inc., Minneapolis, MN) using Box-Behnken experimental design taking a three-factor, three-level approach [13]. The independent variables in the experimental design were phospholipid content (mg), cholesterol content (% of lipid content) and drug content (mg/ml).…”

Section: Optimization Of Sa Loaded Liposomes By the Design Of Experim...mentioning

confidence: 99%

Box-Behnken Design Optimization of Salicylic Acid Loaded Liposomal Gel Formulation for Treatment of Foot Corn

CHANDWANI,

SAINI,

SONI

et al. 2023

Int J App Pharm

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Objective: The present research is aimed to design and optimize a liposomal gel formulation of salicylic acid (SA) for enhanced drug permeation, higher skin drug retention, sustained release drug delivery and reduced side effects in the effective treatment of foot corn. Methods: Formulation designing and optimization of SA-loaded liposomes was done by box-Behnken experimental design using the three-factor, three-level approach. Phospholipid content, cholesterol content and drug content were selected as independent variables; while the critical quality attributes (CQAs) of liposomal formulation like particle size, PDI, zeta potential, entrapment efficiency and cumulative % drug release were considered as response variables. The SA-loaded liposomes were prepared by ethanol injection method and were characterized for desired CQAs. Finally, topical gel formulation of SA-loaded liposomes was developed and evaluated for drug content, homogeneity, spreadability, in vitro drug release, drug release kinetics, ex-vivo drug permeation and skin retention properties. Results: The particle size, PDI, zeta potential, entrapment efficiency and cumulative % drug release of SA-loaded liposomes was found to be 261.2 nm, 0.28, 0.7 mV, 57.53% and 99.57%, respectively. Developed topical gel formulation of SA-loaded liposomes exhibited a sustained drug release profile (64.48% cumulative release over 360 min) following Higuchi model kinetics. The developed formulation showed almost 2-fold enhanced drug permeation (i.e., 26.50%) and more than 2-fold higher drug retention (i.e., 10.90%) on porcine ear skin as compared to the plain salicylic acid gel. Conclusion: The SA-loaded liposomes and developed topical gel formulation possessed all desired CQAs. The in vitro drug release kinetics, ex-vivo drug permeation and skin retention studies confirmed the suitability of the developed formulation for topical application in the effective treatment of foot corn.

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Box-Behnken Design for Optimization of Formulation Variables for Controlled Release Gastroretentive Tablet of Verapamil Hydrochloride

Cited by 4 publications

References 23 publications

Design and optimization of the seed conveying system for belt-type high-speed corn seed guiding device

Design and optimization of the seed conveying system for belt-type high-speed corn seed guiding device

Formulation and Development of Mucoadhesive Nasal Drug Delivery of Ropinirol HCL for Brain Targeting

Box-Behnken Design Optimization of Salicylic Acid Loaded Liposomal Gel Formulation for Treatment of Foot Corn

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