Bowiea volubilis Harv. ex Hook.f. (Sea Onion): In Vitro Culture and the Production of Cardiac Glycosides

Finnie, J.F.; Drewes, F. E.; Staden, J. Van

doi:10.1007/978-3-662-30369-6_6

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Cardiac glycosides are steroidal compounds that have proved to be fruitful in developing potential drugs for congestive heart failure [21]. Cardiac glycosides have long been isolated and characterized in B. volubilis [56][57][58]. These compounds consist of an aglycone or genin, which is bound to one or two sugar molecules [36,59].…”

Section: Phytochemistry Of B Volubilismentioning

confidence: 99%

“…However, it has been reported that seed and bulb scale propagation are both too slow at multiplying the needed plant material [40]. They turned to the micropropagation technique with tissue culture and found that it had saved the population of B. volubilis [56]. Through this technique, thousands of plantlets that can be used in the cultivation of this species have been produced [12].…”

Section: Conservation Statues Of B Volubilismentioning

confidence: 99%

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Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications

Gwanya,

Cawe,

Egbichi

et al. 2023

Life

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Bowiea volubilis subsp. volubilis is primarily used to address human respiratory infections, coughs, and colds due to its diverse pharmaceutical properties. Notably, the plant contains alkaloids that exhibit notable antifungal, antibacterial, and cytotoxic properties. Additionally, the presence of saponins, with recognized antioxidant and anticancer attributes, further contributes to its medicinal potential. Steroid compounds inherent to the plant have been associated with anti-inflammatory and anticancer activities. Moreover, the bulb of B. volubilis has been associated as a source of various cardiac glycosides. Despite these therapeutic prospects, B. volubilis remains inedible due to the presence of naturally occurring toxic substances that pose risks to both animals and humans. The review focuses on a comprehensive exploration concerning B. volubilis ethnobotanical applications, phytochemical properties, and diverse biological activities in relation to in vitro and in vivo applications for promoting human health and disease prevention. The aim of the study is to comprehensively investigate the phytochemical composition, bioactive compounds, and potential medicinal properties of Bowiea volubilis, with the ultimate goal of uncovering its therapeutic applications for human health. This review also highlights an evident gap in research, i.e., insufficient evidence-based research on toxicity data. This void in knowledge presents a promising avenue for future investigations, opening doors to expanded inquiries into the properties and potential applications of B. volubilis in the context of human diseases.

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Section: Phytochemistry Of B Volubilismentioning

confidence: 99%

Section: Conservation Statues Of B Volubilismentioning

confidence: 99%

Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications

Gwanya,

Cawe,

Egbichi

et al. 2023

Life

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“…Of the plants specified for traditional use for UTIs (Table 1), none had their therapeutic dosage ranges recorded. It is noteworthy that several of these species have been reported to contain cardiac glycoside toxins (for example, Bowiea volubilis and Acokanthera oppositifolia) [70,85,86] and cucurbitacin (widely distributed in the Cucurbitaceae, Rubiaceae, Euphorbiaceae, and Cruciferae families), which have several adverse effects and toxicities [87]. us, further studies into the pharmacological and safety profiles of the majority of the plants listed in Table 1 are required to determine their safety for the treatment of UTIs.…”

Section: Dosage and Toxicitymentioning

confidence: 99%

A Review of Plant-Based Therapies for the Treatment of Urinary Tract Infections in Traditional Southern African Medicine

Cock

Mavuso

Vuuren

2021

Evidence-Based Complementary and Alternative Medicine

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Urinary tract infections (UTIs) are amongst the most common bacterial infections globally, with ∼11% of the world’s population contracting at least one infection annually. Several South African plants are used in traditional healing systems to treat UTIs, yet the therapeutic potential of these plants against bacteria that cause UTI remains poorly explored. This study documents southern African plant species used traditionally to treat UTIs. An extensive literature review was undertaken to document the southern African plant species that are used in traditional South African medicine to treat UTIs, thereby highlighting gaps in the current research that require further study. One hundred and fifty-three southern African plant species that are used to treat UTIs were identified. Eighty-five southern African plants were identified as having noteworthy inhibitory activity against the major UTI-causing bacteria. Few of those studies screened against all of the bacterial causes of UTIs, and none of those studies examined the mechanism of action of the plant preparations. Furthermore, many of those studies did not test the toxicity of the plant extracts, so an evaluation of the safety for therapeutic usage was lacking. Substantial further research is to determine their potential for therapeutic use.

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In vitro propagation, proscillaridin A production and antibacterial activity in Drimia robusta

Baskaran

Singh

Staden

2013

Plant Cell Tiss Organ Cult

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Bowiea volubilis Harv. ex Hook.f. (Sea Onion): In Vitro Culture and the Production of Cardiac Glycosides

Cited by 4 publications

References 16 publications

Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications

Bowiea volubilis: From “Climbing Onion” to Therapeutic Treasure—Exploring Human Health Applications

A Review of Plant-Based Therapies for the Treatment of Urinary Tract Infections in Traditional Southern African Medicine

In vitro propagation, proscillaridin A production and antibacterial activity in Drimia robusta

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