Bowen's disease with invasive adnexal carcinoma: The pluripotential nature of Bowen's disease cells

Kawanishi, Hideki; Kitajima, Yasuo; Ban, Masanori

doi:10.1111/j.1346-8138.2006.00196.x

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Subsequent hypotheses have included collision tumors, adnexal tumors with secondary BD‐like epidermal involvement (eg, as in bowenoid eccrine porocarcinoma), or neoplasia arising from intraepidermal adnexal structures. Several authors have suggested the possibility of a common origin from a pluripotent epithelial stem cell . In support of this concept, Misago et al recently noted expression of CK19, a marker of stem cells, in a case of BD with trichilemmal differentiation .…”

Section: Discussionmentioning

confidence: 92%

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Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. From a microscopic perspective, care must be taken to exclude a collision tumor as well as other combined cutaneous neoplasms featuring squamous and glandular differentiation. Direct continuity between the two epithelial phenotypes helps to establish the correct diagnosis and generates interesting speculation about the pathogenesis of these and other epithelial skin tumors. We describe a case of BD in continuity with an invasive adenocarcinoma exhibiting mucinous sweat gland differentiation on the face of an elderly man. Details of the case are outlined with the objective of adding to a scant literature on this topic.

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Section: Discussionmentioning

confidence: 92%

“…Rarely, cases of BD yielding an invasive adnexal carcinoma have been reported. These include BD in association with sebaceous, trichilemmal, and poroid neoplasia . Even less frequent are reports of BD associated with invasive apocrine/mucinous glandular differentiation .…”

Section: Introductionmentioning

confidence: 99%

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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“…Mai et al 21 refer to a pagetoid variant of actinic keratosis and the presence of divergent sweat gland differentiation has been reported in Bowen’s disease 22 – 24. There are, however, no reports thus far describing the presence of acrosyringial or poral differentiation in conventional cutaneous SCCs.…”

Section: Discussionmentioning

confidence: 99%

The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases

2007

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The findings suggest a possible role for ultraviolet radiation and chronic immunosuppression in the induction of malignant squamous differentiation in a subset of EPCs. Further reports on this histological variant of EPC are required to determine whether a pathogenetic link does indeed exist or whether these tumours simply represent a unique variant of squamous cell carcinoma with divergent acrosyringial differentiation.

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“…There were also cases of TLC with primary cutaneous anaplastic large-cell lymphoma, a ductal eccrine component, nevus sebaceous, or a proliferating trichilemmal cyst ( 9 – 12 ). Some cases were combined with other carcinoma at the lesions, four cases with BCC ( 13 , 14 ), two cases with Bowen’s disease ( 15 , 16 ), and one case with Merkel cell carcinoma ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Sun

Zhang²,

Xiao³

et al. 2023

Front. Oncol.

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BackgroundTrichilemmal carcinoma (TLC) is a rare malignant cutaneous adnexal neoplasm, with no relatively comprehensive research.ObjectiveThe aim of this study is to perform an updated statistical analysis so as to better understand TLC’s epidemiology, clinical features, diagnosis, and treatment.MethodsThe diagnosis and treatment of three TLC cases in our department were summarized. Then, all TLC cases published in the literature were retrieved for a comprehensive analysis, followed by the analysis of global trends and regional distribution, demographic characteristics, clinical features, pathogenesis, histopathological features, and treatment and prognosis of TLC.ResultsOf the 231 cases, the incidence of TLC has shown an upward trend recently, especially in China, in Asia. The susceptible population is men aged 60–80 and women over 80, and the most prone location is head and neck. The phenotype of TLC is not always typical and may be misdiagnosed because of the coexistence of other diseases. There is a linear relationship between the diameter and its duration or thickness. UV, locally present skin lesions, trauma, scarring, organ transplantation, and genetic disorders may trigger the occurrence of TLC. Periodic acid–Schiff staining and CD34, but not Epithelial Membrane Antigen (EMA), were helpful in the diagnosis of TLC. Although effective, surgical excision and Mohs micrographic surgery need further improvement to reduce recurrence of TLC. Carcinoma history is an independent risk factor for TLC recurrence.LimitationsThe limitation of this study is the lack of randomized controlled trial on TLC treatment and recurrence.ConclusionTLC has the possibility of invasive growth and recurrence, especially in patients with longer duration and carcinoma history.

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Bowen's disease with invasive adnexal carcinoma: The pluripotential nature of Bowen's disease cells

Cited by 6 publications

References 20 publications

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

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