Bowen's Disease of the Nail Bed and Periungual Area

Sau, Purnima; Mcmarlin, Stacy L.; Sperling, Leonard C.; Katz, Robert

doi:10.1001/archderm.1994.01690020070012

Cited by 116 publications

(29 citation statements)

References 27 publications

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“…It has been reported that BD of the nail unit predominantly affects males at the age of 50–70 years [1,2]. Since then a rather large number of women has also been reported (n = 20; table 1).…”

Section: Resultsmentioning

confidence: 99%

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High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.

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Section: Resultsmentioning

confidence: 99%

“…Therefore, it is frequently misdiagnosed for many years. Furthermore, it appears to be associated with human papillomavirus (HPV) infections whereas this is a rather rare event in BD of the exposed skin [1,2]. However, the precise aetiology of BD of the nail unit is unclear.…”

Section: Introductionmentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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“…Several types of HPV have been detected in 66-83% of cases of BD12.13). In BD, low-risk HPV alone has been detected in only one case 1'), whereas high-risk HPV has been demonstrated in many cases 13,14). In the present study, histological specimens of BD, BC and BP from 67 patients were assessed for the presence of high-risk and low-risk HPV using ISH, and the relationship between the occurrence of high-and low-risk HPV and clinicopathological features was investigated.…”

Section: Introductionmentioning

confidence: 89%

In Situ Hybridization (ISH) Analysis for Human Papillomavirus (HPV) Infection in Bowen's Disease, Bowen Carcinoma and Bowenoid Papulosis of the Skin

Hamada

Kushima

Iijima

2007

The Showa University Journal of Medical Sciences

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: Human papillomavirus (FIPV) infection plays a role in the development of Bowen's disease (BD). The aim of this study was to examine the correlation between HPV infection and Bowen's disease (BD), Bowen carcinoma (BC) and Bowenoid papulosis (BP). We investigated the occurrence of low-risk mucosal HPV (low-risk HPV) and high-risk mucosal HPV (highrisk HPV) in histological specimens obtained from 67 patients with BD in 52, BC in 13, and BP in 2 lesions by in situ hybridization (ISH). Low-risk HPV was detected in 4 lesions, whereas high-risk HPV was detected in 47 (70.1%) lesions. Using clinical data, high-risk HPV infection of BD and BC was observed in 27 of 32 lesions (84.4%) in males and in 18 of 33 lesions (54.5%) in females. Significant differences in the thickness of keratosis and the epidermis were evident between lesions positive for high-risk HPV and those negative for high-risk HPV infection. These findings show that there is a high level of high-risk HPV infection in BD, BC and BP lesions. The level of high-risk HPV was lower in BC than in BD, but not to a significant degree, therefore high-risk HPV may not participate in tumor cell invasion of dermis. Although a higher occurrence of high-risk HPV was observed in males than in females, the cause was unknowen. There was no correlation between the level of high-risk HPV and clinical features, including lesion location, size, disease duration and patient age. HPV increases keratinocytes, therefore the corneum and epidermis may be thicker in HPV-positive high-risk lesions than in HPV-negative lesions in BD and BC. It is highly likely that HPV infects more corrnified lesions.

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“…The patient underwent a second Mohs' surgical excision of the tumor, and the wound was again left to heal by second intention. Bowen's disease of the nail tissue mainly affects males in the 40-to 70-year age group [1,2,5,6]. The left-sided first, second and third fingers seem to be predilection sites [1,5].…”

Section: Case Reportmentioning

confidence: 99%

“…Bowen's disease of the nail apparatus is a squamous cell carcinoma in situ predominantly affecting males in the range from 40 to 60 years [1]. In this localization, the disease seems to have a more aggressive behavior than its skin counterpart.…”

Section: Introductionmentioning

confidence: 99%

Bowen’s Disease of the Nail

Ongenae

Kerckhove²,

Naeyaert³

2002

Dermatology

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We present a case of Bowen’s disease of the nail bed in a 60-year-old male. This case should remind us to biopsy any chronic lesion of the nail in order to reduce the delay in diagnosis. Indeed Bowen’s disease of the nail unit often presents as a clinically misleading ‘benign’ lesion. Early diagnosis is important as this precancerous lesion appears to have a more aggressive behavior when it affects the nail unit. Bowen’s disease of the nail is therefore considered as a squamous cell carcinoma, and both entities are grouped under the term ‘epidermoid carcinoma’. Surgical excision is the first treatment option for those tumors without bone involvement. Our patient was treated with Mohs’ micrographic surgery which is considered the ideal surgical treatment as it ensures a complete eradication of the tumor in over 90% of the cases but also maximally preserves normal tissue and function. This case illustrates the challenge of Mohs’ surgery on the nail unit due to its particular anatomy and histology.

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Bowen's Disease of the Nail Bed and Periungual Area

Cited by 116 publications

References 27 publications

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

In Situ Hybridization (ISH) Analysis for Human Papillomavirus (HPV) Infection in Bowen's Disease, Bowen Carcinoma and Bowenoid Papulosis of the Skin

Bowen’s Disease of the Nail

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