Bowen disease on the dorsum of the foot associated with human papillomavirus type 16

Murao, Kazutoshi; Yamasaki, Kanako; Agawa, Hirokazu; Nakajima, Miyo; Iwasaka, Maiko; Kubo, Yoshiaki

doi:10.2152/jmi.69.152

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In particular, skin lesions of BD occurred on the fingers in 5 patients and on the feet in 1 patient. Previous studies indicated that HPV infection may be a potential risk factor for BD ( 10 ), multiple BD on the finger associated with HPV-34 ( 11 ) and HPV-16 ( 12 ), and BD on the dorsum of the foot associated with HPV-16 ( 13 ). Therefore, it is necessary to test HPV for BD occurring in the fingers and feet.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study

Zhou,

Jiang,

Zhang

et al. 2023

Front. Med.

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BackgroundBowen’s disease (BD) is a slow-growing precancerous skin condition, often concurrent with other diseases, with a high misdiagnosis rate. Previous studies show that patients with BD in different populations have differentiated characteristics.Materials and methodsA retrospective study was conducted in a tertiary hospital in Shenzhen, China. Data about demographic information, diagnosis and treatment, clinical and pathological characteristics, and comorbidities of 50 patients with BD were collected and analyzed.ResultsClinical data of onset age and disease course of 43 patients with BD were available, the average onset age of male and female patients are 55.1 (standard deviation (SD) = 15.29) and 58.2 (SD = 15.59) years old, respectively; the average disease course of male and female patients are 25.3 (SD = 28.63) and 33.9 (SD = 49.65) months, respectively. The onset age (p = 0.52) and disease course (p = 0.49) between male and female patients are not significantly different. Interestingly, there is a negative correlation between onset age and disease course (r = −0.245, p = 0.11). The correct rate of clinical diagnosis is relatively low (54.00%); Some patients with BD are misdiagnosed as Bowenoid papulosis (10.00%), actinic keratosis (8.00%), basal cell carcinoma (8.00%), seborrheic keratosis (6.00%), and pigmented naevus (4.00%). Trunk and limbs are the most common distribution sites of BD lesions, and 94.00% patients with BD are treated with surgical resection; 66.00% patients with BD had comorbidities, including skin diseases (48.48%), cardiovascular diseases (39.39%), gastrointestinal diseases (30.30%), respiratory diseases (27.27%), and tumors (18.18%). The most commonly observed histopathological characteristics of BD are squamous-cell hyperplasia (86.00%), disordered maturation with atypical keratinocytes (74.00%), atypical mitoses (60.00%), hyperkeratosis with hypokeratosis (48.00%), dermal inflammatory cell infiltration (36.00%), and koilocytosis (22.00%).ConclusionBD often occurs in middle-aged and elderly people and is easily misdiagnosed. The onset age and disease course of patients with BD are not significantly different between males and females, whereas there is a negative correlation between the onset age and disease course. BD is more likely to occur in trunk and limbs in the Chinese population, and most patients with BD are concurrent with comorbidities.

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Section: Discussionmentioning

confidence: 99%

Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study

Zhou,

Jiang,

Zhang

et al. 2023

Front. Med.

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“…The involvement of the E6 protein of HPV in the degradation of the tumour suppressor protein p53, leading to the development of cervical cancer, is a well-established fact ( 4 – 6 ). In addition, dysregulation of the Rb/p16INK4a pathway is believed to play a significant role in HPV-induced BD, although the precise underlying mechanisms remain to be fully elucidated ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

A Case of Bowen’s Disease in the Periungual Region: Raising the Possibility of Genitodigital Transmission of Human Papillomavirus Between Sexual Partners

Kim,

Uh,

Kim

et al. 2023

Acta Derm Venereol

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Bowen disease on the dorsum of the foot associated with human papillomavirus type 16

Cited by 2 publications

References 5 publications

Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study

Clinical and histopathological characteristics, diagnosis and treatment, and comorbidities of Bowen’s disease: a retrospective study

A Case of Bowen’s Disease in the Periungual Region: Raising the Possibility of Genitodigital Transmission of Human Papillomavirus Between Sexual Partners

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