Bowen Disease and Risk of Subsequent Malignant Neoplasms

Jæger, Ane Bonnerup; Gramkow, Anne; Hjalgrim, Henrik; Melbye, Mads; Frisch, Mørten

doi:10.1001/archderm.135.7.790

Cited by 54 publications

(11 citation statements)

References 23 publications

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“…A large population-based Danish cohort study confirmed that patients with Bowen’s disease have an excess risk of nonmelanomatous skin cancer and found a 2-fold increase in the risk of lung cancer in male patients with Bowen’s disease on sun-protected areas (Jaeger et al 1999). The different mutagenic mechanisms associated with arsenic compared with those of other genotoxic agents have been reflected in mutational spectra of specific genes.…”

Section: Discussionmentioning

confidence: 99%

A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine

Lee

Bebb

2005

Environ Health Perspect

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Chronic arsenic toxicity occurs primarily through inadvertent ingestion of contaminated water and food or occupational exposure, but it can also occur through medicinal ingestion. This case features a 53-year-old lifetime nonsmoker with chronic asthma treated for 10 years in childhood with Chinese traditional medicine containing arsenic. The patient was diagnosed with Bowen’s disease and developed extensive-stage small-cell carcinoma of the lung 10 years and 47 years, respectively, after the onset of arsenic exposure. Although it has a long history as a medicinal agent, arsenic is a carcinogen associated with many malignancies including those of skin and lung. It is more commonly associated with non–small-cell lung cancer, but the temporal association with Bowen’s disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer. Individuals with documented arsenic-induced Bowen’s disease should be considered for more aggressive screening for long-term complications, especially the development of subsequent malignancies.

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Section: Discussionmentioning

confidence: 99%

A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine

Lee

Bebb

2005

Environ Health Perspect

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“…Bowen's disease is synonymous with squamous cell carcinoma in situ and was originally described by James T. Bowen in 1912 [ 1 ]. It is a disease of old age (median age of presentation is 6 th /7 th decade of life) with slight female predilection [ 2 , 3 ]. The most common sites of affliction are head and neck (29-54%) and scalp (with a predilection towards male) is involved in around 20% of the cases [ 4 ].…”

Section: Purposementioning

confidence: 99%

Recurrent Bowen’s disease of scalp treated with high dose rate surface mold brachytherapy: a and review of the literature

Gandhi¹,

Laviraj²,

Kashyap³

et al. 2014

jcb

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Our case is a 46-year-old female presenting to us with Bowen's disease of scalp since 5 years. Patient had failed topical therapy with 5% 5-florouracil, 0.1% tacrolimus and was intolerant to topical imiquimod. At presentation, she had 15 cm × 10 cm erythematous, hyperpigmented, crusted plaque with irregular border in the superior and lateral aspect of left side of scalp with extension in to forehead. Patient was treated with computed tomography based customized surface mold high dose rate brachytherapy with Iridium-192 to a dose of 35 Gy in 10 fractions (twice daily, 6 hours apart) over 5 days. Patient tolerated the treatment well and showed regression of the lesion with mild dermatitis at the end of treatment. Though dermatitis increased at 2 weeks, at 4 weeks post treatment there was near complete resolution of the lesion with adjacent alopecia. At 8 weeks after completion of the treatment, there was complete resolution of the lesion and patient was asymptomatic. Alopecia in the adjacent area has resolved and the skin pigmentation has begun. Patient is satisfied with both the disease control and the cosmetic outcome of the procedure. Our case report demonstrates successful application of surface mold high dose rate brachytherapy in the treatment of recurrent Bowen's disease of the scalp. Brachytherapy can play an important role in the management of recurrent malignant and premalignant diseases of the complex treatment sites like scalp and it's non-hesitant use should be encouraged in appropriately selected patients at the earliest.

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“…The risk of progression to invasive SCC is about 3-5%, as this risk increases up to 10% in genital localisation, as the scrotal SCC is the most common form of it [ 5 ]. The presence of ulceration or nodular formation is indicative of malignant transformation, but at later stages [ 3 ].…”

mentioning

confidence: 99%

“…In the past, the association between BD and internal malignancies had been described to vary between 15 and 70% in different studies, as it was mostly reported in a patient with arsenic-induced BD [ 4 ]. Nowadays, the disease is not considered as paraneoplastic in general [ 5 ].…”

mentioning

confidence: 99%

Genital Bowenʼs Disease in a Bulgarian Patient: Complete Remission after Surgical Approach

Tchernev¹,

Lotti²,

Wollina³

et al. 2017

Open Access Maced J Med Sci

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A 60-year-old male patient presented with complaints of persistent red to a brown-colored plaque on his scrotum, with duration of approximately three years. The patient had been treated with oral and topical antifungals for inguinal tinea for several months and after that with topical corticosteroids for eczema for several more months. None of the regimens achieved any therapeutic effect. The histopathological evaluation revealed the presence of atypical keratinocytes in all layers of the epidermis with the altered epidermal pattern, spread parabasal mitotic activity, without secondary satellites, multiple dyskeratotic cells and multinucleated cells. The diagnosis of an intraepithelial non-invasive squamous cell carcinoma, associated with koilocytic dysplasia and hyperplasia was made, meeting the criteria for Bowen disease. An elliptic surgical excision of the lesion was made, while the defect was closed with single stitches, with excellent therapeutic and aesthetic result. First described by John T. Bowen in 1912, Bowen disease (BD) represents a squamous cell carcinoma (SCC) in situ with the potential for significant lateral spread. Treatment options include the application of topical 5-flurorouracil cream – useful in non-hairy areas, imiquimod cream or destructive methods such as radiation, curettage, cryotherapy, laser ablation and photodynamic therapy, especially useful in nail bed involvement. Despite the early lesions, surgical excision is the preferred treatment option, regarding the potential malignant transformation risk.

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Bowen Disease and Risk of Subsequent Malignant Neoplasms

Cited by 54 publications

References 23 publications

A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine

A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine

Recurrent Bowen’s disease of scalp treated with high dose rate surface mold brachytherapy: a and review of the literature

Genital Bowenʼs Disease in a Bulgarian Patient: Complete Remission after Surgical Approach

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