Bowel Sound Quantitation to Evaluate Drugs on Gastrointestinal Motor Activity

Martin, D.C.; Beckloff, Gerald L.; Arnold, John D.; Gitomer, S

doi:10.1177/009127007101100106

Cited by 7 publications

(4 citation statements)

References 2 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tertiary amine, oxybutynin, has been shown to be an effective spasmo lytic in a number o f in vitro smooth muscle preparations, and to be o f clinical value in the treatment o f gastrointestinal and urinary tract hypermotility (4,6,8,9,11,13,15). In this laboratory oxybutynin has been shown to exert a moderate anticholinergic effect on rabbit detrusor in vitro, midway in potency between that o f the tertiary amine, atropine, and the smooth muscle relaxant, papaverine.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Oxybutynin Antagonism of Drug-Induced Spasms in Detrusor

Anderson

Fredericks²

1977

Pharmacology

View full text Add to dashboard Cite

Oxybutynin chloride exerts a moderate anticholinergic effect on rabbit detrusor in vitro, which is reversible and competitive in nature (Kg = 4.7 × 10^–9), and midway in potency between atropine and papaverine. In addition, oxybutynin strongly antagonizes BaCl₂-induced spasms of detrusor with a potency equivalent to that of papaverine and 10 times that of atropine. This musculotropic spasmolytic effect is slightly greater in rabbit than human or monkey tissue, and noncompetitive (pD₂ = 5.5). This direct relaxant effect, unlike that of papaverine, is not mediated by the inhibition of tissue phosphodiesterase, but probably reflects oxybutynin’s local anesthetic properties and associated effects on Ca⁺⁺ fluxes and binding.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of the Oxybutynin Antagonism of Drug-Induced Spasms in Detrusor

Anderson

Fredericks²

1977

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Gut stimulants such as carbachol and magnesium sulphate lead to an increased production of bowel sounds [ 46 ]. Furthermore, Martin et al [ 47 ] studied the effect of anti-spasmodic drugs, oxybutynin and dicyclomine on gastrointestinal activity using a microphone with a panasonic recorder embedded in a polystyrene cotton-padded box. A decrease in bowel sounds following drug administration was noted.…”

Section: Effect Of Modifiable and Non-modifiable Factors On Bowel Soundsmentioning

confidence: 99%

Practicing Digital Gastroenterology through Phonoenterography Leveraging Artificial Intelligence: Future Perspectives Using Microwave Systems

Redij

Kaur

Muddaloor

et al. 2023

Sensors

View full text Add to dashboard Cite

Production of bowel sounds, established in the 1900s, has limited application in existing patient-care regimes and diagnostic modalities. We review the physiology of bowel sound production, the developments in recording technologies and the clinical application in various scenarios, to understand the potential of a bowel sound recording and analysis device—the phonoenterogram in future gastroenterological practice. Bowel sound production depends on but is not entirely limited to the type of food consumed, amount of air ingested and the type of intestinal contractions. Recording technologies for extraction and analysis of these include the wavelet-based filtering, autoregressive moving average model, multivariate empirical mode decompression, radial basis function network, two-dimensional positional mapping, neural network model and acoustic biosensor technique. Prior studies evaluate the application of bowel sounds in conditions such as intestinal obstruction, acute appendicitis, large bowel disorders such as inflammatory bowel disease and bowel polyps, ascites, post-operative ileus, sepsis, irritable bowel syndrome, diabetes mellitus, neurodegenerative disorders such as Parkinson’s disease and neonatal conditions such as hypertrophic pyloric stenosis. Recording and analysis of bowel sounds using artificial intelligence is crucial for creating an accessible, inexpensive and safe device with a broad range of clinical applications. Microwave-based digital phonoenterography has huge potential for impacting GI practice and patient care.

show abstract

“…It was found by Politzer et al 14 that, the contents of the intestine influence the frequency content of the sounds as well as the energy of the sounds. In addition, it was found that different regions of the abdominal tract are likely to produce sounds with different characteristic frequencies and amplitudes 15 . A study by Yoshino et al 16 concentrated specifically on the frequency of sounds detected at a single location on the abdominal wall.…”

Section: Introductionmentioning

confidence: 99%