Bowel Function and Gastrointestinal Quality of Life Among Adults Operated for Hirschsprung Disease During Childhood

Abstract

Although bowel function deteriorates with increasing age after operated HD, it is associated with only slightly decreased gastrointestinal quality of life.

Long-term results of total colonic agangliosis patients treated by preservation of the aganglionic right hemicolon and the ileo-cecal valve

“…These two patients have the lowest BF and QoL scores. Related to a recent bowelfunction assessment of classic rectosigmoid HD patients compared with a healthy control group by Jarvi and colleagues [40], the BFS of most of our TCA patients was comparably reduced as observed in rectosigmoid HD patients who were reported on a mean BFS of 17.1 ± 2.8. Nevertheless, one of our TCA patients achieved a normal BFS of 19 points when compared to the mean BFS of 19 ± 1.2 obtained from healthy individuals by Jarvi and colleagues [40].…”

“…Related to a recent bowelfunction assessment of classic rectosigmoid HD patients compared with a healthy control group by Jarvi and colleagues [40], the BFS of most of our TCA patients was comparably reduced as observed in rectosigmoid HD patients who were reported on a mean BFS of 17.1 ± 2.8. Nevertheless, one of our TCA patients achieved a normal BFS of 19 points when compared to the mean BFS of 19 ± 1.2 obtained from healthy individuals by Jarvi and colleagues [40]. Thus, our results do not confirm earlier findings from a meta-analysis by Laughlin and colleagues, which documented that the overall bowel-function rate of TCA patients is poor in about 40 % [37].…”

Neonatal surgery: Towards evidence-based practice and management

“…6,[28][29][30] Crosssectional studies are relatively easy and rapid to perform, while prospective follow-up studies are more time consuming. An inherent limitation in pediatric surgical cross-sectional studies includes a wide age range of patients, which is taken into account when evaluating the results.…”

“…Typical outcome variables are a function of an organ system, for example, bowel function, quality of life and occurrence of other symptoms related to the condition, for example, asthma after repair of esophageal atresia. 5,6 Cross-sectional studies as such are not very valuable; however, significant value is added if controls are used. Cross-sectional case-control studies that use healthy controls that are matched by age, gender, and municipality can give valuable information about the morbidity burden that is associated with a population of patients with a neonatal surgical condition.…”

“…Cross-sectional case-control studies that use healthy controls that are matched by age, gender, and municipality can give valuable information about the morbidity burden that is associated with a population of patients with a neonatal surgical condition. [6][7][8] Cross-sectional case-control studies are difficult to design and also not very expensive to perform. These studies can utilize many different outcome variables.…”