Bowel Dysfunction Management

Masnata, Giuseppe; Manca, Valeria; Chia, Laura; Esu, Francesca

doi:10.1007/978-3-319-42193-3_29

Cited by 1 publication

(4 citation statements)

References 13 publications

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“…Recurrent UTI as a result of CAKUT may predispose children to renal scarring, hypertension and CKD, which carries the risk of progression to ESRD requiring renal replacement therapy [2] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

“…Prevention of UTI in this group of patients is advocated due to their increased risk of renal scarring, hypertension and end stage kidney failure [2] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

“…The use of antimicrobial prophylaxis in patients with CAKUT and recurrent UTI is still controversial [10] [12] [13] [14]. Those opposing the use of prophylactic antibiotics voice the concern that this practice may breed resistant strains of pathogens, increase the risk of breakthrough infections, and encourage adverse drug reactions.…”

Section: Introductionmentioning

confidence: 99%

“…They also argue that the effectiveness of antibiotic prophylaxis is questionable, and that many patients will need to be treated to benefit one child. Finally, they fear that any benefiting from this practice may be interrupted by low adherence of patients to the prescribed medication [10] [12] [13] [14].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antibiotics Prophylaxis in Patients with CAKUT, Does It Actually Prevent UTI? A Single Center Experience at South Africa

Okoronkwo¹,

Mudi²,

Levy³

et al. 2018

OJNeph

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Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are a well-documented risk factor for the development of urinary tract infection (UTI) in children. Prevention of UTI in this group of patients is advocated due to their increased risk of renal scarring, hypertension and end stage kidney failure. Methods: A 10-year retrospective review of CAKUT patients at the Johannesburg Academic Hospital, who were placed on prophylactic antibiotics over a certain period was done. The rate of UTI, the types of causative organisms isolated and the efficacy of prophylactic antibiotics in preventing UTI were documented. Results: Thirty-six (36) out of 134 patients had been started on prophylactic antibiotics after the diagnosis of CAKUT was made. There was a statistically significant association between the use of prophylactic antibiotics and the rate of UTI (p < 0.001). Patients who were not on a prophylactic antibiotic were five times more likely to have a UTI than those who were on a prophylactic antibiotic (OR = 5.21, P = 0.001, 95% CI: 1.9906-13.6277). There was a statistically significant association between the type of bacteria isolated and the use of antibiotic prophylaxis (p = 0.031). Conclusion: Antibiotic prophylaxis was very effective in decreasing the rate of UTI in our cohort of patients with CAKUT.

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Section: Introductionmentioning

confidence: 99%

“…Prevention of UTI in this group of patients is advocated due to their increased risk of renal scarring, hypertension and end stage kidney failure [2] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%