Bowel dysfunction and irritable bowel syndrome in fibromyalgia patients

Sívrí, A.; Cindaş, Abdullah; Dinçer, Fitnat; Sıvrı, Bülent

doi:10.1007/bf02229708

Cited by 79 publications

(42 citation statements)

References 17 publications

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“…9,10 No previous study has examined the co-occurrence of a comprehensive array of overlapping symptoms and conditions among patients diagnosed as having CFS, FM, or TMD. We hypothesized that, given the similarities between CFS, FM, and TMD, symptoms consistent with overlapping conditions such as IBS and interstitial cystitis and others would likewise be commonly observed.…”

Section: Statistical Analysesmentioning

confidence: 99%

Overlapping Conditions Among Patients With Chronic Fatigue Syndrome, Fibromyalgia, and Temporomandibular Disorder

Aaron¹,

Burke²,

Buchwald³

2000

Arch Intern Med

496

302

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Section: Statistical Analysesmentioning

confidence: 99%

Overlapping Conditions Among Patients With Chronic Fatigue Syndrome, Fibromyalgia, and Temporomandibular Disorder

Aaron¹,

Burke²,

Buchwald³

2000

Arch Intern Med

496

302

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“…Patients with IBS and other chronic inflammatory disorders of the gastrointestinal tract often experience chronic widespread pain (Tobin and Kimmey, 2001). Because endotoxins cause muscle pain, conditions such as fibromyalgia, which frequently co-exist with inflammatory conditions such as Crohn's disease (Sperber et al, 1999), IBS (Sivri et al, 1996;Barton et al, 1999;Sperber et al, 1999) and interstitial cystitis (IC) (Jasmin et al, 1998), may develop secondary to processes that allow increased concentrations of endotoxins into the circulation. It is noteworthy that trauma, surgery and infection, conditions that increase circulating endotoxins, are anecdotal events commonly reported to coincide with the onset of fibromyalgia.…”

Section: Discussionmentioning

confidence: 99%

Movement-evoked hyperalgesia induced by lipopolysaccharides is not suppressed by glucocorticoids

Kovács

Papic

Larson

2008

Pain

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Systemic exposure to lipopolysaccharides (LPS) produces a variety of effects, including movementevoked hyperalgesia that can be measured using the grip force assay in mice. Because both lethality and enhanced sensitivity to cutaneous pain following exposure to endotoxins have each been attributed to inflammatory mediators, we explored the possibility that LPS-induced movementevoked hyperalgesia is also sensitive to manipulations of glucocorticoids that regulate these other LPS responses. We found that the hyperalgesic effect of LPS (5 mg/kg s.c.) in mice that were adrenalectomized did not differ from that in control mice that were sham-operated, even though mortality after LPS was potentiated by adrenalectomy. The development of tolerance to the movement-evoked hyperalgesic effect of LPS also did not differ between adrenalectomized and sham-operated control mice. In addition, mifepristone (25 mg/kg s.c.), a glucocorticoid antagonist, did not attenuate the hyperalgesic effect of LPS (2 mg/kg s.c.), yet this dose of mifepristone was sufficient to enhance the incidence of lethality induced by LPS. Enhancement of glucocorticoid activity by two injections of dexamethasone (1 mg/kg s.c.) had no effect on the degree of hyperalgesia in mice injected with LPS (5 mg/kg s.c.), yet this dose of dexamethasone was sufficient to attenuate the incidence of mortality induced by LPS in adrenalectomized mice. Finally, morphine (10 mg/kg i.p.) reversed the decrease in grip force caused by LPS (5 mg/kg i.p.), supporting the interpretation that decreases in grip force produced by LPS reflect muscle hyperalgesia that is not sensitive to glucocorticoids.

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“…Several studies conducted for more than a decade underline the benefits of physical training, although some systematic reviews of literature [11,71,72] did not report clearly the effectiveness of this therapeutic option. Such therapy can follow some pain and disability assessments (including various physical tests, pain assessment, and several questionnaires about quality of life, anxiety and depression), which allow for a rigorous longitudinal follow-up [47].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with FM usually have additional complaints such as pronounced fatigue, sleep disturbances, psychological distress, articular pain, muscular spasms and morning stiffness [91]. The coexistence of FM with other non-musculoskeletal affections, such as genitourinary disorders, irritable bowel syndrome or restless leg syndrome, are frequent [28,72,74,82,85,91,94].…”

Section: Introductionmentioning

confidence: 99%

Benefits of physical training in fibromyalgia and related syndromes

Maquet

Demoulin

Croisier

et al. 2007

Annales de Réadaptation et de Médecine Physique

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Objective. -To review the published information on physical training for fibromyalgia (FM) and related syndromes. Methods. -A search of Medline literature (via Ovid and PubMed) with the following keywords: FM, chronic fatigue syndrome, therapy, rehabilitation, aerobic, exercise, and cognitive behavioral therapy. The reference lists of articles were examined for additional related articles.Results. -Several studies investigated the benefits of graded exercise therapy for patients with FM or related syndromes. Although some systematic reviews have not established an unequivocal benefit of physical training, most authors report a benefit for patients with chronic pain or fatigue. Ideally, such a therapy should be a part of multidisciplinary program. Muscular rehabilitation is reserved for preventing the deconditioning syndrome often reported in patients and the vicious cycle of pain, avoidance and inactivity behaviors, or even kinesiophobia, deconditioning, incapacity and psychological distress.Conclusion. -This review emphasizes the relevance of graded physical training for treating FM and related syndromes. The development of rehabilitation centers, with experts able to propose a relevant therapy to patients with chronic pain or fatigue, should help alleviate this public health problem.

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Bowel dysfunction and irritable bowel syndrome in fibromyalgia patients

Cited by 79 publications

References 17 publications

Overlapping Conditions Among Patients With Chronic Fatigue Syndrome, Fibromyalgia, and Temporomandibular Disorder

Overlapping Conditions Among Patients With Chronic Fatigue Syndrome, Fibromyalgia, and Temporomandibular Disorder

Movement-evoked hyperalgesia induced by lipopolysaccharides is not suppressed by glucocorticoids

Benefits of physical training in fibromyalgia and related syndromes

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