Bowdichine, a new diaza-adamantane alkaloid from <i>Bowdichia virgilioides</i>

Barbosa-Filho, José Maria; Almeida, Jackson Roberto Guedes da Silva; Costa, Vicente Carlos O.; Cunha, Emídio Vasconcelos Leitão da; Silva, Marcelo Sobral da; Braz-Filho, Raimundo

doi:10.1080/1028602031000119763

Cited by 26 publications

(13 citation statements)

References 9 publications

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“…Phytochemical studies carried out on the bark and root materials have revealed the presence of tannins and lupeol (Calle et al 1983), alkaloids and terpenoids (Torrenegra et al 1985, Marinho et al 1994, volatile constituents and flavonoids (Arriaga et al 1998, Veloso et al 1999 and dihydrobenzofuran (Melo et al 2001). There were also reports of a novel alkaloid named bowdichine and two new isoflavonoids from the stem bark of this plant (Barbosa-Filho et al 2004, Juck et al 2006. To the best of our knowledge, no scientific reports on the anti-610 WANDER M. BARROS et al inflammatory or analgesic effects of this plant were so far available.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Barros

Rao

Silva

et al. 2010

An. Acad. Bras. Ciênc.

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Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Barros

Rao

Silva

et al. 2010

An. Acad. Bras. Ciênc.

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“…AGRA et al and podopetaline (Barbosa-Filho et al 2004). The antimicrobial property from B. virgilioides has been attributed to its essential oil of seeds (Almeida et al 2006) and leaves (J.G.R.…”

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confidence: 99%

Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

Agra¹,

Pires²,

Carvalho³

et al. 2013

An. Acad. Bras. Ciênc.

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The decoction of the stem barks from Bowdichia virgilioides KUNTH is a folk remedy used to treat inflammatory disorders in Latin American and Brazil. In the present study, the wound healing activity of aqueous extract of the stem bark from B. virgilioides, called AEBv, was evaluated by the rate of healing by wound contraction and period of epithelization at different days post-wound using the wound excisional model. On day 9, the AEBv-treated animals exhibited significative reduction in the wound area when compared with controls. In wound infected with S. aureus, the AEBv significantly improved the wound contraction when compared to the saline-treated mice. The histological analysis showed that AEBv induced a collagen deposition, increase in the fibroblast count and few inflammatory cells than compared to saline-treated group. The expression of collagen type I was increased in the group treated with AEBv as indicated by immunohistochemical staining. In vitro, the AEBv was effective only against S. aureus but not against P. aeruginosa. Together, the results of this study demonstrate, for the first time, the healing and antimicrobiological effects of aqueous extract of the stem bark from B. virgilioides in the therapy of skin wounds.

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“…Several phytochemical studies of this species disclosed the presence of alkaloids (4,(7)(8)(9), flavonoids (3,(10)(11)(12), benzofuranoids (11,13) and triterpenoids (13)(14)(15). In previous works, the essential oil from the fruits of B. virgilioides showed a high percentage of farnesol, geraniol and b-caryophyllene (16), while Arriaga et al (17) reported the presence of 4-ethyl-2-methoxyphenol (11%), 2-tridecanone (54.6%) and 2-pentadecanone (9 %) as major compounds in the oil of the roots harvested from Ceará state, Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…Bowdichia vigilioides seeds are used in Brazilian folk medicine to treat rheumatism, arthritis, skin diseases, blood purification, diabetes and malaria (2)(3)(4)(5)(6). Several phytochemical studies of this species disclosed the presence of alkaloids (4,(7)(8)(9), flavonoids (3,(10)(11)(12), benzofuranoids (11,13) and triterpenoids (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Volatile Constituents and Antibacterial Activity From Seeds ofBowdichia virgilioidesKunt

Rodrigues

Alves

Nogueira

et al. 2009

Journal of Essential Oil Research

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Bowdichine, a new diaza-adamantane alkaloid from Bowdichia virgilioides

Cited by 26 publications

References 9 publications

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Evaluation of wound healing and antimicrobial properties of aqueous extract from Bowdichia virgilioides stem barks in mice

Volatile Constituents and Antibacterial Activity From Seeds ofBowdichia virgilioidesKunt

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