Bovine viral diarrhoea virus induces apoptosis in blood mononuclear cells by a mechanism largely dependent on monocytes.

Lambot, Michel; Hanon, Emmanuel; Lecomte, C.; Hamers, Claude; Letesson, Jean‐Jacques; Pastoret, Paul-Pierre

doi:10.1099/0022-1317-79-7-1745

Cited by 32 publications

(18 citation statements)

References 26 publications

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“…These results did not confirm what observed in a recent experimental infection trial (Archambault et al., 2000), but a similar pattern was observed in another study (Stokstad and Loken, 2002). Monocytes significantly decreased both in number and in proportion in comparison with control heifers confirming that these cells are one of the major targets for the virus (Bielefeldt Ohmann et al., 1987; Lambot et al., 1998; Archambault et al., 2000; Glew et al., 2003). Platelets showed a significant increase in number when compared with control animals confirming a recent study on PI animals (Walz et al., 2005).…”

Section: Discussionmentioning

confidence: 80%

Comparison of Blood Non‐Specific Immune Parameters in Bovine Virus Diarrhoea Virus (BVDV) Persistently Infected and in Immune Heifers

Piccinini

Luzzago

Frigerio

et al. 2006

Journal of Veterinary Medicine, Series B

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Several data from different authors show that Bovine virus diarrhoea virus (BVDV) could be a key component in multiple-etiology diseases, indeed a lower leukocytes number and their impaired functions decrease the resistance to infections. However, most of the information on the impairment of immune function during BVDV infections arise from circumstantial evidence and from experimental infection studies, and few from field data. To assess the effects of BVDV on blood cells parameters, cellular and humoral functions under field conditions, we designed a controlled study in commercial dairy herds, comparing persistent infected (PI) and healthy heifers. A total of 45 heifers were considered, the PI animals were nine, the control animals were 34, while two controls were considered as acute infected animals. The comparison of the mean values in PI calves showed a significant decrease for leukocytes and granulocytes, while platelets showed a significant increase, when compared with control animals. The total number of lymphocytes decreased not significantly in PI animals, while the proportion significantly increased. The number and proportion of monocytes was significantly reduced in PI animals, when compared with controls. The data collected on markers of cellular immunity during our study cannot be compared with the literature because there are no reference values. The presence of a persistent infection affected the cellular enzymes: NAGase, lysozyme and respiratory burst showed a large statistically significant decrease in PI animals when compared with controls. The presence of a persistent infection with BVD virus influenced blood cells number and impaired some blood cell functions. Such impairment confirms that PI animals represent a threat to the herd not only because they could spread BVDV, but also because they are more susceptible to other infectious diseases.

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Section: Discussionmentioning

confidence: 80%

Comparison of Blood Non‐Specific Immune Parameters in Bovine Virus Diarrhoea Virus (BVDV) Persistently Infected and in Immune Heifers

Piccinini

Luzzago

Frigerio

et al. 2006

Journal of Veterinary Medicine, Series B

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“…Cells infected by pestiviruses of the cp biotype round up, detach from the monolayer, and die, most likely, due to the induction of apoptosis (Hoff & Donis, 1997;Jordan, Wang, Graczyk, Block, & Romano, 2002;Lambot et al, 1998;Perler, Schweizer, Jungi, & Peterhans, 2000;Schweizer & Peterhans, 1999;Vassilev & Donis, 2000;Yamane, Kato, Tohya, & Akashi, 2006), whereas replication of noncp viruses does not lead to microscopically detectable alterations in cells.…”

Section: The Molecular Basis Of Cytopathogenicity In Pestivirusesmentioning

confidence: 98%

The Molecular Biology of Pestiviruses

Tautz

Tews

Meyers

2015

Advances in Virus Research

200

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“…BVDV can cause severe immunossupression, following acute, persistent or subclinical infections. The immunossupression is associated with transient leucopenia, neutrophil disfunction and other immunological disturbances such as apoptosis of peripheral blood mononuclear cells (Coria et al, 1983;Lambot et al, 1988). This immunossupressive effect appears to impair the ability of the animal to clear virus or bacteria from its blood and tissues.…”

Section: Introductionmentioning

confidence: 99%

Co-infections with bovine herpesvirus type 5 and bovine viral diarrhoea virus

Spilki

Silva

Esteves

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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A AB BS ST TR RA AC CT TDuring a series of experiments attempting to reproduce clinically apparent bovine herpesvirus type 5 (BoHV-5) infections, a group of calves was inadvertently infected with bovine viral diarrhoea virus (BVDV). Another group of calves was infected with BoHV-5 only. This paper reports the outcome of such infections. Two out of six calves solely infected with BoHV-5 displayed moderate to severe clinical signs. Three out of four calves of the group co-infected with BoHV-5 and BVDV developed severe clinical signs, two of them died. BoHV-5 virus was isolated to higher titres and for a longer period from the group of calves infected with both viruses. These results suggest that BVDV may enhance clinical signs induced by BoHV-5 and may also play a role in extending the period of BoHV-5 shedding.Keywords: BoHV-5, BVDV, co-infection, experimental inoculation RESUMO Durante a realização de experimentos envolvendo inoculações experimentais com herpesvírus bovino tipo 5 (BoHV-5), um grupo de bovinos foi acidentalmente também inoculado com vírus da diarréia viral bovina (BVDV). Os dados obtidos nesta co-infecção foram então comparados a aqueles observados em animais inoculados exclusivamente com

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Bovine viral diarrhoea virus induces apoptosis in blood mononuclear cells by a mechanism largely dependent on monocytes.

Cited by 32 publications

References 26 publications

Comparison of Blood Non‐Specific Immune Parameters in Bovine Virus Diarrhoea Virus (BVDV) Persistently Infected and in Immune Heifers

Comparison of Blood Non‐Specific Immune Parameters in Bovine Virus Diarrhoea Virus (BVDV) Persistently Infected and in Immune Heifers

The Molecular Biology of Pestiviruses

Co-infections with bovine herpesvirus type 5 and bovine viral diarrhoea virus

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