Bovine tuberculosis disturbs parasite functional trait composition in African buffalo

Beechler, Brianna R.; Boersma, Kate S.; Buss, Peter; Coon, Courtney A. C.; Gorsich, Erin E.; Henrichs, Brian; Siepielski, Adam M.; Spaan, Johannie M.; Spaan, Robert S.; Ezenwa, Vanessa O.; Jolles, Anna E.

doi:10.1073/pnas.1903674116

Cited by 13 publications

(14 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16: 20190811 Table 1. Summary information of buffalo parasite community (adapted from Beechler et al 2019 [30]) and prevalence in adult animals (greater than 1.5 years old). Prevalence was calculated at each capture time point by dividing the number infected animals by the total number of animals captured during that time point.…”

Section: Resultsmentioning

confidence: 99%

Age of first infection across a range of parasite taxa in a wild mammalian population

et al. 2020

Self Cite

View full text Add to dashboard Cite

Newborn mammals have an immature immune system that cannot sufficiently protect them against infectious diseases. However, variation in the effectiveness of maternal immunity against different parasites may couple with temporal trends in parasite exposure to influence disparities in the timing of infection risk. Determining the relationship between age and infection risk is critical in identifying the portion of a host population that contributes to parasite dynamics, as well as the parasites that regulate host recruitment. However, there are no data directly identifying timing of first infection among parasites in wildlife. Here, we took advantage of a longitudinal dataset, tracking infection status by viruses, bacteria, protists and gastro-intestinal worms in a herd of African buffalo ( Syncerus caffer ) to ask: how does age of first infection differ among parasite taxa? We found distinct differences in the age of first infection among parasites that aligned with the mode of transmission and parasite taxonomy. Specifically, we found that tick-borne and environmentally transmitted protists were acquired earlier than directly transmitted bacteria and viruses. These results emphasize the importance of understanding infection risk in juveniles, especially in host species where juveniles are purported to sustain parasite persistence and/or where mortality rates of juveniles influence population dynamics.

show abstract

Section: Resultsmentioning

confidence: 99%

Age of first infection across a range of parasite taxa in a wild mammalian population

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, because IFN-γ and lymphocytes are key players in the immune response against many infectious agents, it is likely that their levels of stability affect the infection risk of other pathogens, and reciprocally, that these pathogens have an effect on immune stability. This reciprocal effect may be particularly important in the context of wildlife systems, like buffalo [64], where individuals are typically infected by many pathogens concurrently.…”

Section: Discussionmentioning

confidence: 99%

Immune stability predicts tuberculosis infection risk in a wild mammal

et al. 2019

Self Cite

View full text Add to dashboard Cite

Immunity is one of the most variable phenotypic traits in animals; however, some individuals may show less fluctuation in immune traits, resulting in stable patterns of immune variation over time. It is currently unknown whether immune variation has consequences for infectious disease risk. In this study, we identified moderately stable immune traits in wild African buffalo and asked whether the stability of these traits affected bovine tuberculosis (TB) infection risk. We found that adaptive immune traits such as the level of interferon-γ (IFN-γ) released after white blood cell stimulation, the number of circulating lymphocytes and the level of antibodies against bovine adenovirus-3 were moderately repeatable (i.e. stable) over time, whereas parameters related to innate immunity either had low repeatability (circulating eosinophil numbers) or were not repeatable (e.g. neutrophil numbers, plasma bacteria killing capacity). Intriguingly, individuals with more repeatable IFN-γ and lymphocyte levels were at a significantly higher risk of acquiring TB infection. In stark contrast, average IFN-γ and lymphocyte levels were poor predictors of TB risk, indicating that immune variability rather than absolute response level better captured variation in disease susceptibility. This work highlights the important and under-appreciated role of immune variability as a predictor of infection risk.

show abstract

“…The presence of M. bovis appears to alter the parasite composition, leading to an increase in directly-transmitted, quickly-replicating taxa with simple life cycles. This suggests that a specific profile of pathogens may be favored by BTB infection (Beechler et al 2019). Moreover, buffalo were found to demonstrate a small but significant decrease in strongyles and Anaplasma marginale after BTB infection.…”

Section: Influence Of Co-infections On Gastrointestinal Microbiota Of...mentioning

confidence: 94%

A review of tuberculosis and parasitic disease co-infection in ungulates, with regard to the potential threat to European bison ( Bison bonasus)

Gałązka

Didkowska

Anusz

et al. 2023

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Bovine tuberculosis (BTB) is a dangerous zoonosis which presents a serious problem for endangered species such as European bison (Bison bonasus). Little is known about the influence of parasitic co-infections on the course and diagnosis of tuberculosis in animals. The best known co-infection in cattle is Fasciola hepatica and Mycobacterium bovis. The aim of this study was to review the most recent literature regarding tuberculosis and parasite co-infection in ungulates and relate the results to European bison. Our findings indicate that any comprehensive diagnosis of BTB should include parasitological monitoring, and the possible impact of such invasions on cellular response-based tuberculosis tests should be taken into account. The diagnosis of BTB is complex, as is its pathogenesis, and parasitic infestations can have a significant impact on both. This should be taken into account during further research and monitoring of tuberculosis in European bison.

show abstract

Bovine tuberculosis disturbs parasite functional trait composition in African buffalo

Cited by 13 publications

References 72 publications

Age of first infection across a range of parasite taxa in a wild mammalian population

Age of first infection across a range of parasite taxa in a wild mammalian population

Immune stability predicts tuberculosis infection risk in a wild mammal

A review of tuberculosis and parasitic disease co-infection in ungulates, with regard to the potential threat to European bison ( Bison bonasus)

Contact Info

Product

Resources

About