Bovine theileriosis – An emerging problem in south-eastern Australia?

Islam, M. Khyrul; Jabbar, Abdul; Campbell, Bronwyn E.; Cantacessi, Cinzia; Gasser, Robin B.

doi:10.1016/j.meegid.2011.08.012

Cited by 55 publications

(74 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major clinical signs of this disease include fever, anemia, jaundice, lethargy, weakness, abortion, and/or mortality (16-18), with significant production losses in dairy cattle (22). Thus far, four genotypes (Buffeli, Chitose, Ikeda, and type 5) of T. orientalis have been reported in Australia (13,18,(20)(21)(22)(23).Currently, the diagnosis of oriental theileriosis is usually based on the observation of clinical signs, the detection of piroplasms of T. orientalis in blood smears (19,24,25), and/or the use of serological (26) or conventional molecular techniques (7,27,28). Each of these approaches has limitations.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Presently, 11 genotypes of T. orientalis complex (designated Chitose or type 1, Ikeda or type 2, Buffeli or type 3, types 4 to 8, and N-1 to N-3) have been identified using a number of molecular markers, including major piroplasm surface protein (MPSP) (7,8), 23-kDa piroplasm membrane protein (p23) (9)(10)(11)60), small-subunit (SSU) rRNA gene (8,12,13), and/or the first and second internal transcribed spacers of nuclear ribosomal DNA (ITS-1 and ITS-2, respectively) (12,14). Of these genotypes, Ikeda and Chitose are recognized to be associated with clinical outbreaks of oriental theileriosis, mainly in the Asia-Pacific region (15)(16)(17)(18)(19)(20)(21). The major clinical signs of this disease include fever, anemia, jaundice, lethargy, weakness, abortion, and/or mortality (16)(17)(18), with significant production losses in dairy cattle (22).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

et al. 2015

Self Cite

View full text Add to dashboard Cite

bOriental theileriosis is an emerging, tick-borne disease of bovines in the Asia-Pacific region and is caused by one or more genotypes of the Theileria orientalis complex. This study aimed to establish and validate a multiplexed tandem PCR (MT-PCR) assay using three distinct markers (major piroplasm surface protein, 23-kDa piroplasm membrane protein, and the first internal transcribed spacer of nuclear DNA), for the simultaneous detection and semiquantification of four genotypes (Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex. Analytical specificity, analytical sensitivity, and repeatability of the established MT-PCR assay were assessed in a series of experiments. Subsequently, the assay was evaluated using 200 genomic DNA samples collected from cattle from farms on which oriental theileriosis outbreaks had occurred, and 110 samples from a region where no outbreaks had been reported. The results showed the MT-PCR assay specifically and reproducibly detected the expected genotypes (i.e., genotypes Buffeli, Chitose, Ikeda, and type 5) of the T. orientalis complex, reliably differentiated them, and was able to detect as little as 1 fg of genomic DNA from each genotype. The diagnostic specificity and sensitivity of the MT-PCR were estimated at 94.0% and 98.8%, respectively. The MT-PCR assay established here is a practical and effective diagnostic tool for the four main genotypes of T. orientalis complex in Australia and should assist studies of the epidemiology and pathophysiology of oriental theileriosis in the Asia-Pacific region.T ick-borne diseases (TBDs) pose a major threat to livestock production worldwide and can have a significant impact on farming communities due to economic losses (1). Theileriosis is one of the important TBDs of cattle, sheep, and/or other ruminants, mainly in tropical and subtropical regions of the world (2). In cattle, East Coast fever (ECF) and Mediterranean/tropical theileriosis are due to Theileria parva and Theileria annulata, respectively, whereas oriental theileriosis is caused by Theileria orientalis. The prevalence of various forms of theileriosis in different parts of the world is dependent on the occurrence of suitable tick vectors for their transmission (3).Oriental theileriosis is caused by one or more genotypes of the T. orientalis complex and is transmitted by ixodid ticks, primarily Haemaphysalis spp. (4-6). Presently, 11 genotypes of T. orientalis complex (designated Chitose or type 1, Ikeda or type 2, Buffeli or type 3, types 4 to 8, and N-1 to N-3) have been identified using a number of molecular markers, including major piroplasm surface protein (MPSP) (7, 8), 23-kDa piroplasm membrane protein (p23) (9-11, 60), small-subunit (SSU) rRNA gene (8, 12, 13), and/or the first and second internal transcribed spacers of nuclear ribosomal DNA (ITS-1 and ITS-2, respectively) (12, 14). Of these genotypes, Ikeda and Chitose are recognized to be associated with clinical outbreaks of oriental theileriosis, mainly in the Asia-Pacific region (15-21). The major clin...

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…That T. orientalis (Ikeda) can be transmitted by the movement of tick-infested cattle is supported both by common sense and anecdotal evidence. For example, Islam et al [26] provide strong evidence for such a mode of infection through genetic typing of the pathogen. However, even via this mode of transmission, infection of a naive herd depends on local environmental conditions conducive to tick survival [25].…”

Section: Discussionmentioning

confidence: 99%

“…While many T. orientalis genotypes are endemic in NZ, and cause only rare cases of clinical disease, the Ikeda genotype appears to be associated with high morbidity and mortality haemolytic anaemia [25,26]. The tick Haemaphysalis longicornis is a putative vector for T. orientalis spp.…”

Section: Motivating Examplementioning

confidence: 99%

Bayesian data assimilation provides rapid decision support for vector-borne diseases

Jewell

Brown

2015

J. R. Soc. Interface.

View full text Add to dashboard Cite

Predicting the spread of vector-borne diseases in response to incursions requires knowledge of both host and vector demographics in advance of an outbreak. Although host population data are typically available, for novel disease introductions there is a high chance of the pathogen using a vector for which data are unavailable. This presents a barrier to estimating the parameters of dynamical models representing host-vector-pathogen interaction, and hence limits their ability to provide quantitative risk forecasts. The Theileria orientalis (Ikeda) outbreak in New Zealand cattle demonstrates this problem: even though the vector has received extensive laboratory study, a high degree of uncertainty persists over its national demographic distribution. Addressing this, we develop a Bayesian data assimilation approach whereby indirect observations of vector activity inform a seasonal spatio-temporal risk surface within a stochastic epidemic model. We provide quantitative predictions for the future spread of the epidemic, quantifying uncertainty in the model parameters, case infection times and the disease status of undetected infections. Importantly, we demonstrate how our model learns sequentially as the epidemic unfolds and provide evidence for changing epidemic dynamics through time. Our approach therefore provides a significant advance in rapid decision support for novel vector-borne disease outbreaks.

show abstract

Mutation scanning‐based analysis of Theileria orientalis populations in cattle following an outbreak

Cufos¹,

Jabbar

Carvalho

et al. 2012

Electrophoresis

Self Cite

View full text Add to dashboard Cite

Bovine theileriosis is a tick-borne disease caused by one or more hemoprotozoan parasites of the genus Theileria. In the past, Theileria infection in cattle in Australia was largely asymptomatic and recognized to be associated with Theileria buffeli. However, outbreaks of theileriosis have occurred in beef and dairy cattle in subtropical climatic regions (New South Wales) of Australia. There is also one published report of a recent theileriosis outbreak in a beef farm near Seymour in the southeastern state of Victoria. In order to gain an improved insight into the genetic composition of Theileria populations following this outbreak, we undertook herein an integrated PCR-coupled mutation scanning-sequencing-phylogenetic analysis of sequence variation in part of the major piroplasm surface protein (MPSP) gene within and among samples from cattle involved in the outbreak. Theileria DNA was detected in 89.4% of 94 cattle in the Seymour farm; the genetic analysis showed that the ikeda and chitose genotypes representing the Theileria orientalis complex were detected in 75 and 4.8% of 84 infected cattle, respectively, and that mixed populations of these two genotypes were found in 20.2% of infected cattle. Given unpublished reports of a significant increase in the number of outbreaks in Victoria, future investigations should focus sharply on elucidating the epidemiology of Theileria to subvert the economic impact on the cattle industry in this state. Although used here to explore genetic variation within the T. orientalis complex in Australia, a mutation scanning-based approach has broad applicability to other species of Theileria in other countries.

show abstract

Bovine theileriosis – An emerging problem in south-eastern Australia?

Cited by 55 publications

References 9 publications

Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

Semiquantitative Multiplexed Tandem PCR for Detection and Differentiation of Four Theileria orientalis Genotypes in Cattle

Bayesian data assimilation provides rapid decision support for vector-borne diseases

Mutation scanning‐based analysis of Theileria orientalis populations in cattle following an outbreak

Contact Info

Product

Resources

About