Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies
Abstract:Natural polyamines (PAs) are key players in cellular
homeostasis
by regulating cell growth and proliferation. Several observations
highlight that PAs are also implicated in pathways regulating cell
death. Indeed, the PA accumulation cytotoxic effect, maximized with
the use of bovine serum amine oxidase (BSAO) enzyme, represents a
valuable strategy against tumor progression. In the present study,
along with the design, synthesis, and biological evaluation of a series
of new spermine (Spm) analogues (1–23), a mi… Show more
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