Bovine respiratory syncytial virus-specific immune responses in cattle following immunization with modified-live and inactivated vaccines. Analysis of the specificity and activity of serum antibodies

Ellis, John; Russell, Harold; Cavender, Jacqueline L.; Haven, Thomas R.

doi:10.1016/0165-2427(92)90150-o

Cited by 16 publications

(14 citation statements)

References 23 publications

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“…Essa clivagem libera o denominado peptídeo de fusão ( 131 KKRKRR 136 ), um fragmento hidrofóbico localizado na região aminoterminal da subunidade F1, o qual está diretamente envolvido na inserção da proteína na membrana celular [135,158,171,188]. A proteína de fusão constitui o principal alvo do sistema imune do hospedeiro, sendo que apenas anticorpos direcionados contra a proteína F e a proteína de adesão G são capazes de neutralizar o BRSV [37,47,88,141,144,174]. A subunidade F2 é o determinante de especificidade nas infecções por vírus respiratórios sinciciais [135].…”

Section: Proteínas Viraisunclassified

“…A imunidade adquirida é importante na prevenção de sinais clínicos após reinfecções [90,141]. Anticorpos contra outras proteínas após infecções ou através de vacinação [47]. Ainda que, anticorpos maternos (AMs) estejam presentes no soro de bezerros nascidos de vacas previamente infectadas, a proteção conferida pelos AMs é controversa.…”

Section: Resposta Imune Protetoraunclassified

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Vírus respiratório sincicial bovino

Spilki

Arns

2018

Acta Scientiae. Vet.

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RESUMOO Vírus Respiratório Sincicial Bovino (BRSV) é uma causa importante de doença respiratória, principalmente em bovinos jovens, caracterizada por pneumonia intersticial. A distribuição das infecções pelo BRSV é mundial e o vírus foi identificado em diferentes episódios no Brasil. O vírus pertence ao gênero Pneumovirus da família Paramyxoviridae e o seu genoma RNA não-segmentado de sentido negativo codifica para 10 proteínas. As proteínas de fusão (F) e de adesão (G) constituem os principais alvos para o sistema imune do hospedeiro. Esse fato deve estar relacionado com a grande variabilidade destas proteínas e de seus genes correspondentes, conforme determinado tanto por anticorpos monoclonais quanto por análise filogenética com base em seqüências de nucleotídeos. A transmissão, resposta imune e patogenia das infecções pelo BRSV, foram estudadas no hospedeiro natural sob condições naturais e experimentais; todavia, alguns aspectos da imunobiologia da infecção são ainda pouco conhecidos. O uso de modelos experimentais, especialmente roedores, pode fornecer novas informações sobre esse assunto. O estado atual do diagnóstico laboratorial das infecções e as medidas de controle para prevenir surtos de BRSV também são apresentados e discutidos.Descritores: vírus respiratório sincicial bovino, BRSV, doenças de bovinos. ABSTRACTBovine respiratory syncytial virus (BRSV) is a major cause of respiratory disease, mainly in young cattle, characterized by interstitial pneumonia. Distribution of BRSV infections is worldwide and the virus has been identified in different episodes in Brazil. The virus belongs to the genus Pneumovirus of the Paramyxoviridae family and its negative sense non-segmented RNA genome encodes 10 proteins. Fusion (F) and attachment (G) proteins constitute the main target for immune responses of the host. This fact may be related to the great variability of these proteins and its corresponding genes among field isolates, as determined by both monoclonal antibodies and phylogenetic analysis using nucleotide sequences. Transmission, immune responses and pathogenesis of BRSV infections were studied in the natural host under natural and experimental conditions; however, some aspects regarding the immunobiology of infection are yet poorly understood. The use of experimental models of infection, especially rodents, may provide new information on these subjects. The present status on laboratory diagnosis of infections and control measures to prevent BRSV outbreaks are also presented and discussed.

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Section: Proteínas Viraisunclassified

Section: Resposta Imune Protetoraunclassified

Vírus respiratório sincicial bovino

Spilki

Arns

2018

Acta Scientiae. Vet.

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“…One decision that must be made is to use either MLV or killed vaccination. Both MLV (Ellis et al, 1992) and inactivated vaccine (Ellis et al, 2005) have been shown to be effective in producing an increase in virus neutralizing antibodies as well as decrease lung lesions and reduce virus shedding (Ellis et al, 2005). It is also encouraging that the use of MLV can be used to increase immune protection without adverse effects on performance (Horne et al, 2007).…”

Section: Immune Responsementioning

confidence: 99%

An evaluation of the genetic components of bovine respiratory disease and its influence on production traits

Schneider

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All rights reserved. by ProQuest Information and Learning Company. DEDICATION I would like to dedicate this thesis to both of my parents, John and Carol Schneider. I have been fortunate in my life to have two parents who have shown enormous amount of love and expertise throughout my life. My mom has always been behind me and certainly the first to brag about the accomplishments I have had the opportunity to experience. My dad has given me the desire and the opportunity to learn about all of the aspect of the agriculture world with numerous hands-on experiences. Also, both of my parents have sacrificed so much so that their children could participate and succeed in every activity that we are involved in.

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“…Subsequently, there were a number of studies of antibody responses in cattle vaccinated with commercially available modified-live or inactivated BRSV. In two of these, Ellis et al compared antibody titers, specificities, and neutralization properties in serum from calves treated with commercial MLV or inactivated vaccines 76,77 . Both classes of vaccine induced BRSV-specific antibodies, some of which bound the F protein.…”

Section: Brsv Vaccinesmentioning

confidence: 99%

“…Cell-mediated responses to various BRSV vaccines have also been assessed in a number of studies. In one of these, commercial MLV and inactivated vaccines were compared by monitoring in vitro correlates of CMI, and responses were distinctly different 80 . Antigen-specific lymphocyte proliferation was detected seven days after primary immunization with the adjuvanted, inactivated vaccine and seven days after secondary immunization with the MLV.…”

Section: Brsv Vaccinesmentioning

confidence: 99%

Bovine T cell responses to bovine respiratory syncytial virus and a vaccine vector candidate

Sandbulte

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Bovine respiratory syncytial virus-specific immune responses in cattle following immunization with modified-live and inactivated vaccines. Analysis of the specificity and activity of serum antibodies

Cited by 16 publications

References 23 publications

Vírus respiratório sincicial bovino

Vírus respiratório sincicial bovino

An evaluation of the genetic components of bovine respiratory disease and its influence on production traits

Bovine T cell responses to bovine respiratory syncytial virus and a vaccine vector candidate

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