Bovine quantitative trait loci analysis for growth, carcass, and meat quality traits in an F2 population from a cross between Japanese Black and Limousin

Abe, Tsuyoshi; Saburi, J.; Hasebe, H.; Nakagawa, Tetsuo; Kawamura, Tadashi; Saito, Kunihikó; Nade, Toshihiro; Misumi, Satsuki; Okumura, Toshiaki; Kuchida, Keigo; Hayashi, Takeshi; Nakane, S.; Mitsuhasi, T.; Nirasawa, Keijiro; Sugimoto, Yoshikazu; Kobayashi, Eiji

doi:10.2527/jas.2007-0676

Cited by 39 publications

(31 citation statements)

References 38 publications

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“…Quantitative trait loci that affected LMA have been described previously by Casas et al (1998), Sellick et al (2007), Alexander et al (2007a), and Abe et al (2008) at the centromeric end of BTA2 near MSTN. The myostatin locus (GDF8) has previously been associated with muscular hypertrophy (Kambadur et al, 1997;Grobet et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wagyu-Limousin F2 population1,2

Alexander

Kuehn²,

Smith³

et al. 2009

Journal of Animal Science

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A microsatellite-based genome scan of a Wagyu x Limousin F(2) cross population previously demonstrated QTL affecting LM area and fatty acid composition were present in regions near the centromere of BTA2. In this study, we used 70 SNP markers to examine the centromeric 24 megabases (Mb) of BTA2, including the Limousin-specific F94L myostatin allele (AB076403.1; 415C > A) located at approximately 6 Mb on the draft genome sequence of BTA2. A significant effect of the F94L marker was observed (F = 60.17) for LM area, which indicated that myostatin is most likely responsible for the effect. This is consistent with previous reports that the substitution of Leu for Phe at AA 94 of myostatin (caused by the 415C > A transversion) is associated with increased muscle growth. Surprisingly, several fatty acid trait QTL, which affected the amount of unsaturated fats, also mapped to or very near the myostatin marker, including the ratio of C16:1 MUFA to C16:0 saturated fat (F = 16.72), C18:1 to C18:0 (F = 18.88), and total content of MUFA (F = 17.12). In addition, QTL for extent of marbling (F = 14.73) approached significance (P = 0.05), and CLA concentration (F = 9.22) was marginally significant (P = 0.18). We also observed associations of SNP located at 16.3 Mb with KPH (F = 15.00) and for the amount of SFA (F = 12.01). These results provide insight into genetic differences between the Wagyu and Limousin breeds and may lead to a better tasting and healthier product for consumers through improved selection for lipid content of beef. RightsWorks produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted. ABSTRACT: A microsatellite-based genome scan of a Wagyu × Limousin F 2 cross population previously demonstrated QTL affecting LM area and fatty acid composition were present in regions near the centromere of BTA2. In this study, we used 70 SNP markers to examine the centromeric 24 megabases (Mb) of BTA2, including the Limousin-specific F94L myostatin allele (AB076403.1; 415C > A) located at approximately 6 Mb on the draft genome sequence of BTA2. A significant effect of the F94L marker was observed (F = 60.17) for LM area, which indicated that myostatin is most likely responsible for the effect. This is consistent with previous reports that the substitution of Leu for Phe at AA 94 of myostatin (caused by the 415C > A transversion) is associated with increased muscle growth. Surprisingly, several fatty acid trait QTL, which affected the amount of unsaturated fats, also mapped to or very near the myostatin marker, including the ratio of C16:1 MUFA to C16:0 saturated fat (F = 16.72), C18:1 to C18:0 (F = 18.88), and total content of MUFA (F = 17.12). In addition, QTL for extent of marbling (F = 14.73) approached significance (P = 0.05), and CLA concentration (F = 9.22) was marginally significant (P = 0.18). We also observed associations of SNP located at 16.3 Mb with KPH (F = 15.00) and for the amount of SFA (F = 12.01)...

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Section: Discussionmentioning

confidence: 99%

A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wagyu-Limousin F2 population1,2

Alexander

Kuehn²,

Smith³

et al. 2009

Journal of Animal Science

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“…This way, MAS provides possibility to improve diicult and/or high cost measurement traits, such as the meat faty acids composition. Some studies in several countries have mainly used microsatellite as genetic marker to study the faty acids composition in taurine breeds [56]. However, genotype using microsatellite markers is expensive and just a small proportion of the total genetic variance can be show for the markers, limiting the progress or genetic gain [57].…”

Section: Genomic Selection and Genome-wide Association Studies For Bementioning

confidence: 99%

Genetic Factors that Determine the Meat Fatty Acids Composition

Lemos¹,

Pereira²,

Regatieri³

et al. 2017

Fatty Acids

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In relation the nutritional atributes of beef meat quality, the composition of faty acid is important not only because it afects the meat palatability, but also it can afect the human health. The faty acids harmful to human health have received atenuating atention in recent years. Some studies, with taurine breed, have shown that there is a genetic variation for the trait faty acid proile of the meat and, therefore, the possibility of genetic improvement of this trait in beef catle. Meantime, in zebu catle, the genetic parameter estimates for faty acid proile are scarce. Furthermore, the trait meat faty acid proile is something diicult and costly to measure and for this kind of trait is indicated the use of genomic selection, which is a type of marker-assisted selection. The objective of this chapter is showing the genetic variability of meat faty acid proile diferent catle breeds and makes an approach of the implement models and methods that use genomic information to improve the faty acid composition of beef meat.

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“…QTL strategy is incontestably very powerful (Boichard et al, 2003;Abe et al, 2008) but extremely cumbersome and costly when dealing with large animals such as ruminants. Although recent developments in livestock genomics have revolutionised the mapping and the identification of QTL, the fine mapping remains a real challenge.…”

Section: Discussionmentioning

confidence: 99%

A sensitised mutagenesis screen in the mouse to explore the bovine genome: study of muscle characteristics

Magnol

Monestier

Vuillier-Devillers

et al. 2011

Animal

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Meat yield and quality are closely related to muscle development. The muscle characteristics mainly take place during embryonic and postnatal phases. Thus, genetic control of muscle development in early stages represents a significant stake to improve product quality and production efficiency. In bovine, several programmes have been developed to detect quantitative trait loci (QTL) affecting growth, carcass composition or meat quality traits. Such strategy is incontestably very powerful yet extremely cumbersome and costly when dealing with large animals such as ruminants. Furthermore, the fine mapping of the QTL remains a real challenge. Here, we proposed an alternative approach based on chemical mutagenesis in the mouse combined with comparative genomics to identify regions or genes controlling muscle development in cattle. At present, we isolated seven independent mouse lines of high interest. Two lines exhibit a hypermuscular phenotype, and the other five show various skeletomuscular phenotypes. Detailed characterisation of these mouse mutants will give crucial input for the identification and the mapping of genes that control muscular development. Our strategy will provide the opportunity to understand the function and control of genes involved in improvement of animal physiology.

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Bovine quantitative trait loci analysis for growth, carcass, and meat quality traits in an F2 population from a cross between Japanese Black and Limousin

Cited by 39 publications

References 38 publications

A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wagyu-Limousin F2 population1,2

A Limousin specific myostatin allele affects longissimus muscle area and fatty acid profiles in a Wagyu-Limousin F2 population1,2

Genetic Factors that Determine the Meat Fatty Acids Composition

A sensitised mutagenesis screen in the mouse to explore the bovine genome: study of muscle characteristics

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