Bovine leukemia virus: Early reflections in blood after an experimental infection of calves

Klintevall, K.; Fuxler, Lisbeth; Fossum, Caroline

doi:10.1016/s0147-9571(96)00043-4

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…With the aim to correlate lymphocytosis with a defined B cell sub-population, we have demonstrated that two surface molecules, CD5 and CD11b, whose expression has been previously associated with late stages of BLV infection [13-15,23,24] are also important markers at the seroconversion period. In human and mice, the B lymphocytes expressing the CD5 and CD11b proteins are referred to as B-1a cells.…”

Section: Discussionmentioning

confidence: 99%

“…Following BLV infection, the hosts, either cattle or sheep, develop a persistent antibody response to viral proteins and virions can be isolated from ex vivo cultured leucocytes [9]. Detection of antibodies in the infected animals correlates with a transient B cell lymphocytosis [10-13]. In most cases, BLV infection remains clinically silent, a stage referred to as the asymptomatic or aleukemic stage of the disease [7].…”

Section: Introductionmentioning

confidence: 99%

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et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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et al. 2004

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“…In PBMCs, IFN-γ mRNA expression increases 4 weeks after infection [293] but the antiviral activity remains intriguingly unaffected [294]. In aleukemic cattle, IFNγ mRNA expression is significantly increased compared to those in cattle with persistent lymphocytosis [283].…”

Section: Mecanisms Of Leukemogenesismentioning

confidence: 99%

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

et al. 2007

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In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

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“…Blood-borne IgM ϩ cells, specifically IgM ϩ CD5 ϩ B cells (10), increase early during BLV infection of sheep and calves (11,29,50). The proliferation of IgM ϩ cells exceeds that for mock-infected controls and contributes to the increasing numbers of blood-borne B cells present at the time of seroconversion.…”

Section: Dissemination Of Infected Cells and Amplification Of Infectionmentioning

confidence: 99%

Dissemination of Bovine Leukemia Virus-Infected Cells from a Newly Infected Sheep Lymph Node

Fulton

Portella²,

Radke

2006

J Virol

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To investigate the early establishment of bovine leukemia virus (BLV) infection, we injected BLV-infected or mock-infected allogeneic cells into the shoulder of sheep in which an efferent lymphatic duct of the draining prescapular lymph node had been cannulated. Rare mononuclear cells acting as centers of BLV infection in culture were present within 4 to 6 days in efferent lymph and within 6 to 10 days in blood. Soon after BLV injection, immunoglobulin M ؉ (IgM ؉ ) and CD8 ؉ cells increased in efferent lymph and oscillated reciprocally in frequency. CD8؉ blasts increased on days 4 to 6, when infectious centers increased 100-fold in lymph. On days 6 and 7, both lymph and blood were enriched with CD8؉ cells that were labeled late on day 5 with an intravenous pulse of 5-bromo-2-deoxyuridine (BrdU). Lymph, but not blood, was enriched with BrdU ؉ B cells on day 7. Capsid-specific antibodies became detectable in efferent lymph on days 6 to 8 and surface glycoprotein-specific antibodies on day 9, preceding their detection in serum by 9 to 14 days. Systemic dissemination of BLV-infected cells was thus accompanied by an increase in proliferating CD8؉

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Bovine leukemia virus: Early reflections in blood after an experimental infection of calves

Cited by 9 publications

References 30 publications

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Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

Dissemination of Bovine Leukemia Virus-Infected Cells from a Newly Infected Sheep Lymph Node

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