Bovine leukemia virus detection in humans: A systematic review and meta-analysis

Mendoza, Willington; Isaza, Juan Pablo; López, Lucelly; López, Albeiro; Gutiérrez, Luis Felipe Higuita

doi:10.1016/j.virusres.2023.199186

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…The presence in humans of antibodies that react to BLV antigens supports the theory that a zoonotic transmission of the virus may happen via direct contact or consumption of contaminated products, but a clear transmission mechanism has not been clearly demonstrated, nor has its implication as a causative cancer agent. Moreover, results regarding the actual prevalence of BLV antibodies in serum samples are controversial, ranging from 0% to 74.3% in a recent metanalysis [ 170 ]. Some authors believe transmission from cattle to human to be plausible, as the bovine infection is widespread; consumption of raw, unpasteurized milk and raw or undercooked beef might be the vessel, as the virus is rendered non-infectious by heat.…”

Section: Blvmentioning

confidence: 99%

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Rossi,

Inzani,

Cesari

et al. 2024

Pathogens

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Breast cancer is the most common malignancy in the female sex; although recent therapies have significantly changed the natural history of this cancer, it remains a significant challenge. In the past decade, evidence has been put forward that some oncogenic viruses may play a role in the development of sporadic breast cancer; however, data are scattered and mostly reported as sparse case series or small case–control studies. In this review, we organize and report current evidence regarding the role of high-risk human papillomavirus, mouse mammary tumor virus, Epstein–Barr virus, cytomegalovirus, bovine leukemia virus, human polyomavirus 2, and Merkel cell polyomavirus in the pathogenesis of breast cancer.

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Section: Blvmentioning

confidence: 99%

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Rossi,

Inzani,

Cesari

et al. 2024

Pathogens

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“…Although genome fragments of BLV have been identified in BC patients, the exact etiology has yet to be definitively determined [23,24]. In vitro studies have demonstrated the capability of BLV to infect human mammary cells, and BLV antibodies have been detected in human blood, underscoring the potential threat posed by BLV transmission and propagation in humans [25].…”

Section: Introductionmentioning

confidence: 99%

Are Mouse Mammary Tumor Virus and Bovine Leukemia Virus Linked to Breast Cancer among Jordanian Women?

Khasawneh,

Himsawi,

Sammour

et al. 2024

Microbiology Research

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The investigation into the potential association between retroviruses and breast cancer (BC) presents a fascinating area of research. In this study, the focus was on assessing the presence of two retroviruses, Mouse Mammary Tumor Virus (MMTV) and Bovine Leukemia Virus (BLV), in BC samples and exploring their relationship with relevant clinicopathological variables. The study involved analyzing BC samples from 103 Jordanian female patients diagnosed with BC, as well as breast tissue samples from 25 control patients without evidence of breast malignancy. Real-time PCR was used to investigate the evidence of MMTV and BLV infection in these samples, and the findings were then correlated with various clinicopathological characteristics of BC. The results showed that BLV was detected in 19 (18.4%) of the BC samples, while MMTV was detected in only seven (6.8%). Importantly, none of the control samples tested positive for MMTV or BLV. Additionally, MMTV/BLV co-infections were reported in 1.9% of the BC cases. However, the analysis did not reveal any statistically significant associations between the presence of these retroviruses and various clinicopathological variables, such as age, molecular subtypes of BC, stage, grade, lymph node involvement, tumor size, smoking status, or family history. Despite these findings, it is crucial to acknowledge that further investigation with a larger cohort is necessary to establish a clearer association and elucidate the underlying mechanisms that may explain the exact role of retroviruses in breast carcinogenesis. This study provides insights into the potential infection by MMTV and BLV of BC and lays the groundwork for future research in this area.

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Bovine Leukemia Virus molecular detection and associated factors among dairy herd workers in Antioquia, Colombia

Mendoza,

Isaza,

López

et al. 2024

Acta Tropica

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Bovine leukemia virus detection in humans: A systematic review and meta-analysis

Cited by 5 publications

References 47 publications

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Are Mouse Mammary Tumor Virus and Bovine Leukemia Virus Linked to Breast Cancer among Jordanian Women?

Bovine Leukemia Virus molecular detection and associated factors among dairy herd workers in Antioquia, Colombia

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