Bovine leukaemia virus genotypes 5 and 6 are circulating in cattle from the state of São Paulo, Brazil

Gregory, Lílian; Gaeta, Natália Carrillo; Araújo, Jansen de; Thomazelli, Luciano Matsumiya; Harakawa, R.; Ikuno, A. A.; Okuda, Líria Hiromi; Stéfano, Eliana de; Pituco, Edviges Maristela

doi:10.1099/jmm.0.000639

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…The Env protein is expressed as a precursor gpr72, which is processed into surface (SU) gp51 and transmembrane (TM) gp30 [14–16]. Based on the env gene polymorphism in the gp51 region, BLV is now classified into 10 genotypes (genotype 1 to genotype 10, G1–G10), which are distributed worldwide [17–35]. BLV genotypes have been reported in countries near China, such as the Philippines [28], Korea [29], and Mongolia [30].…”

Section: Introductionmentioning

confidence: 99%

Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China

Wang

Zhou

et al. 2019

BMC Vet Res

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Background Bovine leukemia virus (BLV) causes enzootic bovine leukosis in cattle and leads to heavy economic losses in the husbandry industry. Heilongjiang Province, China, is rich in dairy cattle. However, its current BLV epidemiology and genotypes have still not been evaluated and confirmed. In this report, we investigated the BLV epidemiology in dairy cattle in the major regions of Heilongjiang Province via the nested PCR assay. Results A total of 730 blood samples were collected from nine different farms in six regions of Heilongjiang. The results showed that the infection rate of these regions ranged from null to 31%. With a clustering analysis of 60 published BLV env sequences, genotypes 1 and 6 were confirmed to be circulating in Heilongjiang. Importantly, a new genotype, 11, and a new subgenotype, 6E, were also identified in the Harbin and Daqing regions, respectively. An epitope analysis showed that a cluster of T-X-D-X-R-XXXX-A sequences in genotype 11 gp51 neutralizing domain 2 was unique among all currently known BLV isolates and was therefore a defining feature of this new genotype. Conclusions BLV epidemics and genotypes were initially investigated in dairy cattle of Heilongjiang. A relatively high infection rate was found in some regions of this province. A new genotype, G11, with a highly specific motif, was identified and thus added as a new member to the current BLV genotype family. This report provides an initial reference for future investigations and subsequent control of BLV transmission and spread in this region. Electronic supplementary material The online version of this article (10.1186/s12917-019-1863-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China

Wang

Zhou

et al. 2019

BMC Vet Res

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“…Phylogenetic studies based on genomic sequencing and the gp51 envelope protein have pointed out the existence of 10 BLV genotypes with a wide worldwide distribution. In South America, genotypes I, II, IV, V, VII, and IX have already been identified, and in Brazil genotypes I, II, V, VI, and VII (Polat, Takeshima, & Aida, 2017;Gregory et al, 2017). In a study performed in Santa Catarina State/Brazil, it was observed the circulation of genotypes I, II, VIII, IX, and the genotype X as the most prevalent (47%) (Rodakiewicz et al, 2018).…”

Section: Association Between Blv Infection and Mastitismentioning

confidence: 99%

Intercurrence between bovine leukosis virus infection and mastitis in dairy cattle

Hirsch¹,

Rocha²,

Bruhn³

et al. 2021

Semina: Ciênc. Agrár.

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There are several factors affecting global milk production leading to severe economic losses. Mastitis and leukosis are highly prevalent diseases especially in Brazilian cattle herds. The present study aimed to evaluate the correlation between mastitis and the bovine leukemia virus (BLV) infection in naturally infected cows belonging to dairy herds in Minas Gerais State. Additionally, the prevalence of both diseases, pathogens causing mastitis, and their association with BLV infection and persistent lymphocytosis were evaluated. The prevalence of BLV was determined using the agar gel immunodiffusion test (AGID) in 1,392 lactating cows from ten dairy herds. From the AGID results, 240 cows were selected and divided into two experimental groups: A case group composed of 160 BLV-positive cows (BLV-P) and the control group of 80 BLV-negative cows (BLV-N). Based on serological and leucocytic evaluations, the animals were classified into three subgroups: BLV-N, BLV-P without persistent lymphocytosis (BLV-PWPL), and BLV-positive with persistent lymphocytosis (BLV-PPL). The California Mastitis Test (CMT) was performed on days 0 (D0) and 60 (D60) in the subgroups and the milk from CMT-positive glands were analyzed. BLV infection was present in 100% of herds, with an overall prevalence of 80.9% in cows older than 24 months. Among BLV-P animals, 74% were classified as BLV-PWPL and 26% as BLV-PPL. Coagulase-negative Staphylococcus (73.30%),Corynebacterium spp. (12.04%), Streptococcus agalactiae (8.90%), and Staphylococcus aureus (5.76%) were predominant (61.41%). There were no statistical differences among the scores of clinical or subclinical mastitis with the pathogen type (contagious or environmental) in the BLV-PWPL or BLV-PPL subgroups. However, BLV-P animals showed higher CMT scores than BLV-N animals, suggesting a higher redisposition to subclinical mastitis in cows affected by leukosis.

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Detection and molecular characterization of bovine leukemia virus in various regions of Iran

Kazemimanesh

Madadgar

Steinbach

et al. 2019

Journal of General Virology

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Bovine leukaemia virus genotypes 5 and 6 are circulating in cattle from the state of São Paulo, Brazil

Abstract: BLV is still important in Brazil and this research should be continued.

Cited by 5 publications

References 19 publications

Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China

Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China

Intercurrence between bovine leukosis virus infection and mastitis in dairy cattle

Detection and molecular characterization of bovine leukemia virus in various regions of Iran

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