Bovine jugular vein conduit: What affects its elastomechanical properties and thermostability?

Abstract

The aim of this study was to compare the mechanical properties and thermal stability of the venous wall depending on the treatment method used, and, accordingly, on those structural changes in the tissue that this treatment causes. Bovine jugular vein walls (BJVWs) cross-linked with glutaraldehyde (GA), ethylene glycol diglycidyl ether (DE), and Contegra commercial conduit were evaluated using uniaxial stretching [with and without pre-conditioning (PreC)], differential scanning calorimetry, amino acid analysis, and attenuated total reflection infrared spectroscopy. Fresh BJVW was used as a control. It was shown that failure stress in non-PreC GA-treated and DE-treated materials was lower than that in fresh and Contegra counterparts. Contegra samples were

Current development of bovine jugular vein conduit for right ventricular outflow tract reconstruction

“…These mechanical characteristics, however, as Nichay et al pointed out, was not necessarily inferior, because they were actually more close to the mechanical properties of a native human pulmonary artery (Zhuravleva et al, 2022).…”

“…Hydration also lead to lower mechanical properties (stiffness and failure strength) of the polyepoxy-treated samples compared with their glutaraldehyde-treated counterparts. These mechanical characteristics, however, as Nichay et al pointed out, was not necessarily inferior, because they were actually more close to the mechanical properties of a native human pulmonary artery ( Zhuravleva et al, 2022 ).…”

“…as the crosslinker on vascular grafts in the 1980s and ‘90s, and found that compared with glutaraldehyde, polyepoxy compound reduced the level of calcification and retained the natural elasticity and appearance of the biological materials ( Tomizawa et al, 1988 ; Hata et al, 1992 ; Noishiki et al, 1993 ). This series of studies has recently been furthered by Nichay et al in biochemical and biophysical settings ( Zhuravleva et al, 2018 ; Zhuravleva et al, 2022 ). They quantitatively reported the calcium accumulation in the polyepoxy-treated BJV, which was 25% of that in the glutaraldehyde-treated experimental group, and 40% of that in the commercially available Contegra (also glutaraldehyde-treated).…”

Immobilized Bisphosphonates as Potential Inhibitors of Bioprosthetic Calcification: Effects on Various Xenogeneic Cardiovascular Tissues

“…At the same time, these interactions are obvious for all types of aortic and venous tissue, the ECM of which contains not only collagen but also a lot of elastin, which is difficult to cross-link [ 13 , 33 ]. The presence of non-collagen proteins and their steric transformations during cross-linking [ 34 ] are responsible for decreasing the activity of BPs, despite the higher content of bound BPs in these elastin-rich tissues ( Figure 2 D). The collagen/elastin ratio varies widely depending on the individual, species, nutrients, and other characteristics.…”

Calcification of Various Bioprosthetic Materials in Rats: Is It Really Different?

“…We believe that this cannot be explained by the effect on lipids alone. Alcohols, in particular, isopropanol, significantly affect the conformational structure of the protein [ 17 ], increasing the content of random coils, β-sheets, and side chains, while reducing the level of antiparallel β-sheets and α-helices [ 18 ]. How this may be associated with bioprosthetic mineralization is still unclear.…”