Bovine herpesvirus 1 in semen of bulls and the risk of transmission: A brief review

Oirschot, J.T. van

doi:10.1080/01652176.1995.9694526

Cited by 78 publications

(61 citation statements)

References 29 publications

(42 reference statements)

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“…No entanto, a correlação desta classificação com parâmetros epidemiológicos e clí-nico-patológicos ainda não está bem definida (Van Oirschot 1995). Os isolados de BoHV-1 associados com abortos pertencem principalmente ao subtipo respiratório (BoHV-1.1) e menos freqüentemente ao subtipo BoHV-1.2a (Edwards et al 1991, Miller et al 1991.…”

Section: Introductionunclassified

Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente

et al. 2008

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2) may result in vulvovaginitis and transient infertility. The acute infection is followed by the establishment of latent infection which can be periodically reactivated. We herein describe the virology and clinico-pathological aspects of acute and recrudescent vulvovaginitis in heifers inoculated with a Brazilian BoHV-1.2 isolate recovered from an outbreak of balanoposthitis. Genital inoculation of isolate SV-56/90 (10 8.1 TCID 50 / animal) in four eight-months-old heifers resulted in efficient virus replication in the genital mucosa and the development of moderate to severe vulvovaginitis. The inoculated heifers shed virus in genital secretions in titers up to 10 7.3 TCID 50 /mL until day 10 pi and developed genital congestion, swelling, vesicles and pustules. The vesicles and pustules increased in size eventually coalesced and became covered with a yellowish exsudate. These signs appeared at day 2 pi, increased in severity up to days 5 -8 pi and progressively subsided thereafter. Dexamethasone administration at day 55 pi resulted in virus shedding in vaginal secretions for up to 10 days. Virus reactivation in all animals was accompanied by clinical recrudescence of the disease, yet less severe than during acute infection. Examination of sacral ganglia and lymph nodes by PCR at day 36 postreactivation revealed the presence of latent viral DNA in the pudendal (4/4), genitofemoral, sciatic and rectal caudal (3/4) and obturator nerve ganglia (1/4); in addition to several regional lymph nodes. These results demonstrate the virulence of isolate SV-56/90 for heifers and pave the way for its use in further pathogenesis studies and vaccine-challenge trials.

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Section: Introductionunclassified

Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente

et al. 2008

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“…Genotypes 1.1 and 1.2a are usually more virulent and can be associated to abortions, while strains from genotype 1.2b are usually less virulent and have not been related to abortions (2,10). Although such genomic differences do reflect pathogenic and antigenic differences, to date there is only one recognized antigenic group (16).…”

Section: Introductionmentioning

confidence: 99%

Construction and characterization of a glycoprotein E deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil

Franco¹,

Rijsewijk²,

Flores³

et al. 2002

Braz. J. Microbiol.

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This paper describes the construction and characterization of a Brazilian strain of bovine herpesvirus type 1.2a (BoHV-1.2a) with a deletion of the glycoprotein E (gE) gene. The deletion was introduced by cotransfection of a deletion fragment containing the 5´and 3´gE flanking regions and genomic DNA of wild type BoHV-1 into bovine cells. Isolation of gE deletion mutant was performed by immunoperoxidase staining with an anti-gE monoclonal antibody. Viral clones were plaque purified and further examined by restriction endonuclesase digestion and Southern blot hybridization. This gE deletion mutant will be evaluated as a vaccinal virus, in order to determine its potential use for a differential vaccine.

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“…This subtype has often been isolated from the respiratory tract as well as from abortions, and is prevalent in many countries in Europe as well as in the Americas (Edwards et al 1990, Souza et al 2002. BHV-1.2a, on its turn, has been associated to a broad range of clinical manifestations on both the respiratory and genital tracts such as IBR, infectious pustular vulvovaginitis (IPV) or balanopostitis (IPB), as well as abortions (Oirschot 1995). BHV-1.2a is highly prevalent in Brazil; it was present in Europe before the decade of 1970; after that, it became rare in that continent (Oirschot 1995, D'Arce et al 2002.…”

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“…BHV-1.2b, on its turn, has been associated to respiratory disease as well as to IPV/IPB. Therefore, subtype 2b has not been related to abortion (Oirschot 1995) and has been considered less pathogenic for the respiratory tract than BHV-1.1 (Edwards et al 1990). Subtype 2b has been frequently isolated in Australia and Europe (Edwards et al 1990), but is uncommon in Brazil where, to date, only one virus of this subtype has been so far isolated.…”

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confidence: 99%

“…BHV-1.2a, on its turn, has been associated to a broad range of clinical manifestations on both the respiratory and genital tracts such as IBR, infectious pustular vulvovaginitis (IPV) or balanopostitis (IPB), as well as abortions (Oirschot 1995). BHV-1.2a is highly prevalent in Brazil; it was present in Europe before the decade of 1970; after that, it became rare in that continent (Oirschot 1995, D'Arce et al 2002. BHV-1.2b, on its turn, has been associated to respiratory disease as well as to IPV/IPB.…”

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Comparative pathogenicity of bovine herpesvirus 1 (BHV-1) subtypes 1 (BHV-1.1) and 2a (BHV-1.2a)

Spilki¹,

Esteves²,

Lima

et al. 2004

Pesq. Vet. Bras.

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The study aimed to examine the capacity of two bovine herpesvirus type 1 (BHV-1) isolates of different subtypes (EVI 123/96, BHV-1.1; SV265/98, BHV-1.2a) to induce respiratory disease in calves. These two isolates are representative of the BHV-1 subtypes prevalent in Brazil. Viral subtypes were confirmed by monoclonal antibody analysis and by restriction enzyme digestion of viral genomes. The viruses were inoculated intranasally into seven 3 months old calves (four with BHV-1.1, three with BHV-1.2a). Three other calves of identical age and condition were kept as uninfected controls. In both groups of infected calves, the clinical signs observed were consistent with typical infectious bovine rhinothracheitis (IBR), including pyrexia, apathy, anorexia, nasal and ocular mucopurulent discharges, erosions on the nasal mucosa, conjunctivitis, lachrymation, redness of nasal mucosa, dyspnoea, coughing, tracheal stridor and enlargement of retropharingeal, submandibular and cervical lymphnodes. No significant differences were observed between the clinical scores attributed to both groups. Virus shedding in nasal and ocular secretions were also similar, apart from a significant difference in nasal virus shedding on day 1 to 3 post-inoculation, which was higher for BHV-1.1 than for BHV-1.2a. Following corticosteroid induced reactivation of the latent infection, recrudescence of clinical signs was also observed, with no significant differences on both groups. It was concluded that both subtypes BHV-1.1 and BHV-1.2a were able to induce clinically undistinguishable respiratory disease in calves, either subsequent to a primary infection or following reactivation.

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Bovine herpesvirus 1 in semen of bulls and the risk of transmission: A brief review

Cited by 78 publications

References 29 publications

Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente

Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente

Construction and characterization of a glycoprotein E deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil

Comparative pathogenicity of bovine herpesvirus 1 (BHV-1) subtypes 1 (BHV-1.1) and 2a (BHV-1.2a)

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