Bovine enterovirus as an oncolytic virus: Foetal calf serum facilitates its infection of human cells

Smyth, Michael; Symonds, Alistair L. J.; Brazinova, S; Martin, Noreen

doi:10.3892/ijmm.10.1.49

Cited by 11 publications

(11 citation statements)

References 21 publications

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“…BHV-1 has no pathogenic profile in humans, yet productively replicates and kills a variety of human cancer types. Although several other bovine viruses are being developed as oncolytic viruses, including bluetongue virus 10 (a segmented, dsRNA virus of the family Reoviridae), 27 bovine enterovirus (a ssRNA virus of the family Picornaviridae) [28][29][30] and bovine herpesvirus 4 (a gammaherpesvirus of the genus Rhadinovirus), 31 BHV-1 offers several advantages. First, although bluetongue virus 10, bovine enterovirus and bovine herpesvirus 4 replicate in a broad range of mammalian cells, BHV-1 replication is normally restricted to bovine cells.…”

Section: Discussionmentioning

confidence: 99%

Bovine herpesvirus type 1 as a novel oncolytic virus

2009

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Oncolytic virotherapy is a promising avenue of cancer gene therapy. Current vectors include human viruses that have been engineered to replicate in tumor cells or nonhuman viruses that are naturally oncotropic and preferentially replicate in tumor cells harboring defects in innate immune pathways such as the type 1 interferon (IFN) pathway. Bovine herpesvirus type 1 (BHV-1) is a species-specific herpesvirus closely related to the human herpes simplex virus type 1 (HSV-1). Although BHV-1 does not efficiently replicate in and affect cellular viability of normal human cells, it is capable of infecting and killing various immortalized and transformed human cell types. Surprisingly, BHV-1 infection of human cells fails to elicit IFN production at the mRNA or protein level and the ability of BHV-1 to kill immortalized and transformed human cells does not correlate with defects in IFN pathways. Furthermore, although some cross-reactivity between BHV-1 and HSV-1 exists, the majority of human antibody or serum samples tested failed to neutralize BHV-1 despite possessing HSV-1 neutralizing capacity. Thus, BHV-1 is a novel candidate oncolytic virus with a distinct mechanism of tumor targeting.

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Section: Discussionmentioning

confidence: 99%

Bovine herpesvirus type 1 as a novel oncolytic virus

2009

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“…Both a replicon vector [41] and replication-competent vectors of poliovirus type 1 [42,179], also in a clinical trial (www.wiley.co.uk/genetherapy/clinical/). Live attenuated poliovirus [180] and bovine enterovirus [8,183] in pre-clinical testing Unassigned Live Seneca Valley virus SVV-001 in a clinical trial (www.neotropix.com) Togaviridae…”

Section: Oncolytic Virusesmentioning

confidence: 99%

“…Today, oncolytic vectors based on coxsackievirus A21 are available [38,39], and phase I studies in targeting melanoma with this virus have been completed (results not yet published) [182]. Another oncolytic picornavirus tested in the 1950s, bovine enterovirus, has gained renewed attention as a potential virotherapeutic [8,183]. This virus shows oncolytic potential towards a variety of human cancer cell types, including some of lymphoid origin.…”

Section: Picornavirusesmentioning

confidence: 99%

Oncolytic viruses in cancer therapy

2007

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Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own agents to find and destroy malignant cells. The purpose of this review is to provide an introduction to this very topical field of research and to point out some of the current observations, insights and ideas circulating in the literature. We have strived to acknowledge as many different oncolytic viruses as possible to give a broader picture of targeting cancer using viruses. Some of the newest additions to the panel of oncolytic viruses include the avian adenovirus, foamy virus, myxoma virus, yaba-like disease virus, echovirus type 1, bovine herpesvirus 4, Saimiri virus, feline panleukopenia virus, Sendai virus and the non-human coronaviruses. Although promising, virotherapy still faces many obstacles that need to be addressed, including the emergence of virus-resistant tumor cells.

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“…Within the EV genus both E1 and coxsackievirus A21 have been shown to be oncolytic in several human cancers, including malignant melanoma and ovarian cancer [13-18]. In addition, it has been reported that bovine EV shows oncolytic characteristics [19], and attenuated, recombinant poliovirus strains have been shown to have great oncolytic potential [20-22]. Recently another picornavirus, Seneca valley virus, has also emerged as an oncolytic virotherapy candidate [23,24].…”

Section: Introductionmentioning

confidence: 99%

Cytolytic replication of echoviruses in colon cancer cell lines

Israelsson

Jönsson

Gullberg

et al. 2011

Virol J

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BackgroundColorectal cancer is one of the most common cancers in the world, killing nearly 50% of patients afflicted. Though progress is being made within surgery and other complementary treatments, there is still need for new and more effective treatments. Oncolytic virotherapy, meaning that a cancer is cured by viral infection, is a promising field for finding new and improved treatments. We have investigated the oncolytic potential of several low-pathogenic echoviruses with rare clinical occurrence. Echoviruses are members of the enterovirus genus within the family Picornaviridae.MethodsSix colon cancer cell lines (CaCo-2, HT29, LoVo, SW480, SW620 and T84) were infected by the human enterovirus B species echovirus 12, 15, 17, 26 and 29, and cytopathic effects as well as viral replication efficacy were investigated. Infectivity was also tested in spheroids grown from HT29 cells.ResultsEchovirus 12, 17, 26 and 29 replicated efficiently in almost all cell lines and were considered highly cytolytic. The infectivity of these four viruses was further evaluated in artificial tumors (spheroids), where it was found that echovirus 12, 17 and 26 easily infected the spheroids.ConclusionsWe have found that echovirus 12, 17 and 26 have potential as oncolytic agents against colon cancer, by comparing the cytolytic capacity of five low-pathogenic echoviruses in six colon cancer cell lines and in artificial tumors.

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Bovine enterovirus as an oncolytic virus: Foetal calf serum facilitates its infection of human cells

Cited by 11 publications

References 21 publications

Bovine herpesvirus type 1 as a novel oncolytic virus

Bovine herpesvirus type 1 as a novel oncolytic virus

Oncolytic viruses in cancer therapy

Cytolytic replication of echoviruses in colon cancer cell lines

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