Bovine colostrum supplementation: Potential benefits in human and animal health

Menchetti, Laura; Traina, Giovanna; Casagrande, P; Leonardi, Leonardo; Barbato, Olimpia; Brecchia, Gabriele

doi:10.1016/j.jbiotec.2014.07.293

Cited by 3 publications

(4 citation statements)

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“…These findings suggest the immunomodulatory and anti-inflammatory activity of COL in the calf-FMT C57BL/6 mouse model. Similar insights into the anti-inflammatory properties of colostrum were observed by Menchetti et al, although the exact mechanism was not proposed [47]. Furthermore, we unexpectedly observed that calf-FMT C57BL/6 mice undergoing colostrum feeding exhibited decreased IL-6 production and enhanced IL-10 and IL-12 production compared to untreated calf-FMT C57BL/6 mice or those receiving saline feeding.…”

Section: Discussionsupporting

confidence: 83%

“…A comprehensive review conducted by Menchetti highlighted the diverse activities of COL on human innate and adaptive immune responses, indicating its potential therapeutic applications. Colostrum contains high quantities of maternal immunoglobulins, cytokines, growth factors, and immunomodulatory milk oligosaccharides [47]. These components have been shown to regulate intestinal mucosal responses through interactions with cytokine and growth factor receptors, as well as with various pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) [48].…”

Section: Discussionmentioning

confidence: 99%

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Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Grigalevičiūtė

Matusevičius

Plančiūnienė

et al. 2023

Veterinary Sciences

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Bovine colostrum (COL), the first milk secreted by lactating cows postpartum, is a rich source of bioactive compounds that exert a significant role in the survival, growth, and immune development of neonatal calves. This study investigated the immunomodulatory effects of COL on cytokine production in vitro using a Caco-2/THP-1 macrophage co-culture model stimulated with Phorbol 12-myristate 13-acetate (PMA). COL pretreatment significantly reduced IL-6 (241.3 pg/mL) production induced by PMA (p < 0.05), while increasing IL-10 production (45.3 pg/mL), in comparison to PMA control (441.1 and 12.5 pg/mL, respectively). Further investigations revealed that the IL-6 suppressive effect of colostrum was heat-sensitive and associated with components of higher molecular mass (100 kDa). Moreover, colostrum primarily influenced THP-1 macrophages rather than Caco-2 epithelial cells. The effects of colostrum on IL-6 production were associated with reduced NF-κB activation in THP-1 macrophages. In calf-FMT transplanted C57BL/6 murine model, colostrum decreased intestinal permeability, reduced immune cell infiltration and intestinal score, and suppressed IL-6 (142.0 pg/mL) production during S. typhimurium infection, in comparison to control animals (215.2 pg/mL). These results suggest the immunomodulatory activity of bovine colostrum and its potential applications in inflammatory disorders. Further studies are needed to elucidate the underlying mechanisms and validate the findings in bovine models.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Grigalevičiūtė

Matusevičius

Plančiūnienė

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…These findings suggest the immunomodulatory and anti-inflammatory activity of COL in the calf-FMT C57BL/6 mouse model. Similar insights into the antiinflammatory properties of colostrum were observed by Menchetti et al, although the exact mechanism was not proposed [45]. Furthermore, we unexpectedly observed that calf-FMT C57BL/6 mice undergoing colostrum feeding exhibited decreased IL-6 production and enhanced IL-10 and IL-12 production compared to untreated calf-FMT C57BL/6 mice or those receiving saline feeding.…”

Section: Discussionsupporting

confidence: 82%

“…A comprehensive review conducted by Menchetti, highlighted the diverse activities of COL on human innate and adaptive immune responses, indicating its potential therapeutic applications. Colostrum contains high quantities maternal immunoglobulins, cytokines, growth factors, and immunomodulatory milk oligosaccharides [45]. These components have been shown to regulate intestinal mucosal responses through interactions with cytokine and growth factor receptors, as well as with various pathogenassociated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) [46].…”

Section: Discussionmentioning

confidence: 99%

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Grigalevičiūtė

Matusevičius

Plančiūnienė

et al. 2023

Preprint

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Bovine colostrum (COL), the first milk secreted by lactating cows postpartum, is a rich source of bioactive compounds that exert significant role on the survival, growth, and immune development of neonatal calves [9,10]. This study investigated the immunomodulatory effects of COL on cytokine production in vitro using a Caco-2/THP-1 macrophage co-culture model stimulated with Phorbol 12-myristate 13-acetate (PMA). COL pretreatment significantly reduced IL-6 production induced by PMA, while increasing IL-10 production. Further investigations revealed that the IL-6 suppressive effect of colostrum was heat-sensitive and associated with components of higher molecular mass (100 kDa). Moreover, colostrum primarily influenced THP-1 macrophages rather than Caco-2 epithelial cells. The effects of colostrum on IL-6 production were associated with reduced NF-κB activation in THP-1 macrophages. In calf-FMT transplanted C57BL/6 murine model, colostrum decreased intestinal permeability, reduced immune cell infiltration, and suppressed IL-6 production during S. typhimurium infection. These results highlight the immunomodulatory activity of bovine colostrum and its potential therapeutic applications in inflammatory disorders. Further studies are needed to elucidate the underlying mechanisms and validate the findings in bovine models.

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Individual Peptides Extraction and Characteristics of Cow Colostrum Trypsin Hydrolysate with Biological Activity Assessment

et al. 2022

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The research concerned the trypsin peptides analysis of colostrum hydrolyzate. The authors isolated seven individual peptides: TT1, TT2, TT3, T(1), T1.1, T1.2, mpT. They determined the molecular weight of the peptides and the amino acid sequence in the peptide chain by mass spectrometry; peptides – using the international database Protein NCBI. The mpT peptide contains the largest number of amino acids – 49. The T1.2 peptide is similar to the membrane-active peptide BAMA Bos taurus, which opens prospects for its use as a part of antibacterial agents or as a BAS carrier. In colostrum hydrolyzate the T1 peptide has the T highest concentration (2.04 mg/ml). It consists of 17 amino acids and matches the peptide NCI_CGAP_Brn23 cDNA Homo sapiens clone, which is similar to TR: O35085 ARX HOMEOPROTEIN. The homeobox protein containing the development gene of a PRD-like class is related to the T(1) peptide. This gene in humans is located on the X chromosome and is involved in the central nervous system and pancreas development. According to the results, the researchers isolated peptides from colostrum hydrolyzate, and identified some of them. Still a man understudies the biological role of most of the determined peptides, and has not proved its safety. In this regard, the study aimed at assessing the hydrolyzate cytotoxicity using the Neutral Red Assay method on the HEK293 cell line during a 24-hour incubation. Cytotoxicity in the first, second and third measurements at a concentration of 0.1 mg/ml was: −3.3; −1.0 and 0.20; at a concentration of 0.3 mg/ml: −1.3; −3.5 and −8.7; at 0.5 mg/ml: −2.6; −0.6 and 0.4. The results indicate no toxicity. The authors studied the antimicrobial and antifungal hydrolyzate activity. Colostrum hydrolyzate demonstrates antimicrobial activity against E. coli and B. subtilis bacteria and antifungal activity against C. albicans. The results assert that the peptides are of clinical importance and can serve as a template for the anti-infective drug development.

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Bovine colostrum supplementation: Potential benefits in human and animal health

Cited by 3 publications

References 0 publications

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control

Individual Peptides Extraction and Characteristics of Cow Colostrum Trypsin Hydrolysate with Biological Activity Assessment

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