Bovine chromosome 4 workshop: consensus and comprehensive linkage maps

Casas, Eduardo; Barendse, W.; Beever, J. E.; Burns, B. M.; Davis, Scott K.; Erhardt, G.; Förster, M.; Gomez‐Raya, Luis; Kalm, E.; Kappes, S. M.; Klungland, Helge; Lewin, Harris A.; Lien, Sigbjørn; Olsaker, I.; Reinsch, Norbert; Schwerin, Manfred; Song, Yali; Taylor, Jeremy F.; Thomsen, Hauke; Våge, Dag Inge; Wu, Xueping; Xu, N.; Yeh, C. C.

doi:10.1046/j.1365-2052.1999.00529.x

Cited by 13 publications

(7 citation statements)

References 7 publications

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“…The most likely order using the `ALL' function of CRI‐MAP (version 2.4) was BL1024‐RM188‐RM067‐BM6458‐IGFBP3‐BMS648‐BR6303. This assignment is in agreement with the radiation hybrid map 5 however, the comprehensive linkage map places IGFBP3 between RM067 and BM6458 .…”

Section: Chromosomal Locationsupporting

confidence: 88%

A new polymorphism in the cattle IGFBP3 gene

Thue

Buchanan

2002

Animal Genetics

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Section: Chromosomal Locationsupporting

confidence: 88%

A new polymorphism in the cattle IGFBP3 gene

Thue

Buchanan

2002

Animal Genetics

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“…In contrast, a number of cattle linkage maps exist that have been developed with different sets of families and different sets of loci (Ma et al 1996;Barendse et al 1997;Kappes et al 1997). As a consequence, some difficulties are experienced in moving between the cattle maps to predict relative positions of loci, and several cattle mapping workshops have been held to address these issues (Taylor et al 1998;Casas et al 1999;Gu et al 2000).…”

Section: Discussionmentioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox¹

2001

Genome Research

210

136

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A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between autosomal loci and 8.3 cM between highly polymorphic [polymorphic information content (PIC) Ն 0.7] autosomal loci. The largest gap between markers is 32.5 cM, and the number of gaps of >20 cM between loci, or regions where loci are missing from chromosome ends, has been reduced from 40 in the previous map to 6. Five hundred and seventy-three of the loci can be ordered on a framework map with odds of >1000 : 1. The sheep linkage map contains strong links to both the cattle and goat maps. Five hundred and seventy-two of the loci positioned on the sheep linkage map have also been mapped by linkage analysis in cattle, and 209 of the loci mapped on the sheep linkage map have also been placed on the goat linkage map. Inspection of ruminant linkage maps indicates that the genomic coverage by the current sheep linkage map is comparable to that of the available cattle maps. The sheep map provides a valuable resource to the international sheep, cattle, and goat gene mapping community.Sheep play an important role in modern agriculture and possess many heritable traits that are of economic importance. Additionally, the size, physiology, temperament, and lifespan of sheep make them an appropriate model for studying a variety of mammalian biological functions including lung physiology, immunology, endocrinology, reproduction, embryology, and fetal development. Sheep are also useful as disease models for inherited diseases, such as asthma (Wright et al.

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“…BTA1 and BTA21 (Taylor et al, 1998;Barendse et al, 1993), but not for others, e.g. BTA4 (Casas et al, 1999). It will hence be interesting to determine if a sex-specific difference in map distance will correlate with differences in synapsis initiation in cattle.…”

Section: Bouquet Topology Is Persistent In Male Cattle Prophase Imentioning

confidence: 99%

Centromere and telomere redistribution precedes homologue pairing and terminal synapsis initiation during prophase I of cattle spermatogenesis

Pfeifer¹,

Thomsen²,

Scherthan

2001

Cytogenet Genome Res

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Alterations in nuclear topology associated with meiotic chromosome pairing were studied in premeiotic cells and spermatocytes I of adult bovine males. To this end, we performed FISH with chromosome, pericentromeric satellite-DNA and telomere-specific probes in combination with immunostaining of synaptonemal complex proteins (SCP3, SCP1) on testis tissue sections. Nuclei of premeiotic cells (spermatogonia) exhibited a scattered telomere distribution while pericentromeres formed a few intranuclear clusters. We observed that the chromosome pairing process in cattle prophase I is preceded by repositioning of centromeres and telomeres to the nuclear periphery during preleptotene. Clustering of chromosome ends (bouquet formation) was observed during the transition from leptonema to zygonema and coincided with pairing of a sub-centromeric marker of bovine chromosomes 7. Dissolution of bouquet topology during zygonema left perinuclear telomeres scattered over the nuclear periphery at pachynema. SCP3 staining in frozen tissue sections revealed the appearance of this axial element protein in intranuclear aggregates during preleptotene, followed by extensive axial element formation during leptotene. Synapsis as revealed by SCP1 staining initiated peripherally at earliest zygotene, at this stage nuclei still contained numerous SCP3 clusters. Our observations reveal prominent non-homologous satellite-DNA associations in spermatogonia and indicate the conservation of topological features of the meiotic chromosome pairing process among mammals. The comparison of telomere dynamics in mouse and cattle prophase I suggests that a larger number of chromosomes prolongs the duration of the bouquet stage.

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Bovine chromosome 4 workshop: consensus and comprehensive linkage maps

Cited by 13 publications

References 7 publications

A new polymorphism in the cattle IGFBP3 gene

A new polymorphism in the cattle IGFBP3 gene

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Centromere and telomere redistribution precedes homologue pairing and terminal synapsis initiation during prophase I of cattle spermatogenesis

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