Bovine acute phase response following turpentine injection

Conner, Joe; Eckersall, P. D.; Wiseman, A; Aitchison, Tom; Douglas, T. A.

doi:10.1016/0034-5288(88)90018-5

Cited by 141 publications

(79 citation statements)

References 13 publications

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“…The haptoglobin, ceruloplasmin and fibrinogen concentrations have been reported to increase in many infections and inflammatory conditions in ruminants (Conner and Eckersall, 1988;Conner et al, 1989;Skinner et al, 1991;Pfeffer et al, 1993;Wittum et al, 1996;Horadogada et al, 1999;Ganheim et al, 2003). In our study, haptoglobin, ceruloplasmin and fibrinogen concentrations significantly increased in both groups after administration of bacteria.…”

Section: Discussionsupporting

confidence: 54%

Effect of Mannheimia (Pasteurella) haemolytica Infection on Acute-phase Proteins and Some Mineral Levels in Colostrum–Breast Milk-fed or Colostrum–Breast Milk-deprived Sheep

Ulutaş

Özpınar

2006

Vet Res Commun

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The aim of this study was to investigate the levels of acute-phase proteins and minerals as indicators for the reactivity in 1-year-old sheep. A total of 26 Chios breed sheep were fed colostrum-breast milk (control, n = 15)or were deprived afterseparation from their mother immediately after birth(experimental, n = 11). Mannheimia (Pasteurella) haemolytica serotype A1 was inoculated intratracheally and blood samples were taken in vacuumed sera on days 0, 1, 4, 7, 10, 13, 16, 19 and 22. Antibiotic treatment was initiated after blood sampling on day 22, and blood samples were taken on days 1, 4 and 7 after the treatment. The levels of C-reactive protein (CRP), haptoglobin, ceruloplasmin, fibrinogen, zinc, iron and calcium, which are the indicators of immune function and infectious diseases were analysed. No significant difference between the control and trial groups before and after the infection was determined. However, serum CRP, haptoglobin, ceruloplasmin and fibrinogen levels were increased in the course of the infection. These levels were restored to normal following treatment.

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Section: Discussionsupporting

confidence: 54%

Effect of Mannheimia (Pasteurella) haemolytica Infection on Acute-phase Proteins and Some Mineral Levels in Colostrum–Breast Milk-fed or Colostrum–Breast Milk-deprived Sheep

Ulutaş

Özpınar

2006

Vet Res Commun

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“…Data on Hp levels in individual cattle from previously published studies (Conner et al, 1988;Skinner et al, 1991;Alsemgeest et al, 1994;Young et al, 1995;Saini et al, 1998) and from this study (not shown) have not enabled the establishment of clear and reliable Hp-threshold individually distinguishing cattle with and without abnormalities at meat inspection. However, a previously published study indicated that mean Hp values in slaughtered cattle can be used as indicators correlating with the presence or absence of abnormalities at meat inspection at group level rather than at individual level (Tourlomoussis et al, 2004); this was explored further in the present study.…”

Section: Cattle Without and With Abnormalities At Meat Inspectioncontrasting

confidence: 48%

A Study of Haptoglobin Levels in Groups of Cattle and Pigs With and Without Abnormalities at Meat Inspection

Blagojević

Antić

Dučić

et al. 2011

Foodborne Pathogens and Disease

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A total of 96 bovines originating from 36 farms and 97 pigs from five farms were slaughtered in two multispecies abattoirs and subjected to official meat inspection and haptoglobin (Hp) testing using a single radial immunodiffusion method. No direct correlation between Hp level and specific postmortem abnormalities was found at individual cattle/pig level. However, at animal group level, the mean of Hp values (in both cattle and pigs) were statistically significantly higher in animals with abnormalities than in those without. The study indicated that the mean Hp value in groups of cattle or pigs can be useful as an overall objective indicator of the overall status of cattle/pig batches when analyzing the food chain information as a part of the antemortem inspection at abattoirs, but related specific Hp criteria are currently missing. Because of the large variability and nonspecific nature of Hp-related responses in cattle and pigs, establishing a single, reliable cutoff Hp value differentiating batches that may pose public health risks does not appear as a realistic approach presently. Rather, establishing wider, unsatisfactory/marginal/satisfactory ranges of batch-based Hp values indicating general appropriateness of the cattle/pigs source appears more promising. For that, wider Hp baseline studies are necessary at abattoir.

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“…In support for this, increased blood levels of haptoglobin, SAA and fibrinogen were detected during viral and/or bacterial respiratory infections in calves (e.g. [7,11]). In many of these cases, the calves show no, or only mild, clinical symptoms, that could easily be missed in a group of calves in a farm [11].…”

Section: Introductionmentioning

confidence: 78%

Acute Phase Proteins in Response to Dictyocaulus viviparusInfection in Calves

2004

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Three experiments were carried out to examine the acute phase response, as measured by the acute phase proteins (APP) haptoglobin, serum amyloid A (SAA) and fibrinogen, in calves infected with lungworm, Dictyocaulus vivparus. In addition, eosinophil counts were analysed. Three different dose models were used in 3 separate experiments: I) 250 D. viviparus infective third stage larvae (L3) once daily for 2 consecutive days, II) 100 D. viviparus L3 once daily for 5 consecutive days, and III) 2000 L3 once. All 3 dose regimes induced elevated levels of haptoglobin, SAA and fibrinogen, although there was considerable variation both between and within experiments. A significant increase was observed in all 3 APP at one or several time points in experiment I and III, whereas in experiment II, the only significant elevation was observed for fibrinogen at one occasion. The eosinophil numbers were significantly elevated in all 3 experiments. The results show that lungworm infection can induce an acute phase response, which can be monitored by the selected APP. Elevated APP levels in combination with high numbers of eosinophils in an animal with respiratory disease may be used as an indicator of lung worm infection, and help the clinician to decide on treatment. However, high numbers of eosinophils and low levels of APP do not exclude a diagnosis of lungworm. Thus, lungworm infection may not be detected if measurements of APP are used to assess calf health in herds or individual animals.

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Bovine acute phase response following turpentine injection

Cited by 141 publications

References 13 publications

Effect of Mannheimia (Pasteurella) haemolytica Infection on Acute-phase Proteins and Some Mineral Levels in Colostrum–Breast Milk-fed or Colostrum–Breast Milk-deprived Sheep

Effect of Mannheimia (Pasteurella) haemolytica Infection on Acute-phase Proteins and Some Mineral Levels in Colostrum–Breast Milk-fed or Colostrum–Breast Milk-deprived Sheep

A Study of Haptoglobin Levels in Groups of Cattle and Pigs With and Without Abnormalities at Meat Inspection

Acute Phase Proteins in Response to Dictyocaulus viviparusInfection in Calves

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