Abstract:The objective was to exploit the raw data output from a scalable home cage (type IIL IVC) monitoring (HCM) system (DVC®), to characterize pattern of undisrupted rest and physical activity (PA) of C57BL/6J mice. The system's tracking algorithm show that mice in isolation spend 67% of the time in bouts of long rest (>=40s) and 59 % of the time was interpreted as sleep. Twenty percent is physical activity (PA), split equally between local movements and locomotion. Decomposition revealed that a day contains ~65… Show more
“…While the average Tb is similar in mice and humans [ 21 ], in frequently sampled data mice have transient Tb excursions of 1–2 °C. These short-term Tb changes, referred to as ultradian cycles, occur during both the light and dark phases and are associated with physical activity [ 22 , 23 ]. Importantly, similar ultradian Tb cycles do not occur in humans.…”
“…While the average Tb is similar in mice and humans [ 21 ], in frequently sampled data mice have transient Tb excursions of 1–2 °C. These short-term Tb changes, referred to as ultradian cycles, occur during both the light and dark phases and are associated with physical activity [ 22 , 23 ]. Importantly, similar ultradian Tb cycles do not occur in humans.…”
Electrophysiological methods of research are widely used in neurobiology. To assess the bioelectrical activity of the brain in small laboratory animals, electrocorticography (ECoG) is most often used, which allows the recording of signals directly from the cerebral cortex. To date, a number of methodological approaches to the manufacture and implantation of ECoG electrodes have been proposed, the complexity of which is determined by experimental tasks and logistical capabilities. Existing methods for analyzing bioelectrical signals are used to assess the functional state of the nervous system in test animals, as well as to identify correlates of pathological changes or pharmacological effects. The review presents current areas of applications of ECoG in neuropharmacological studies in small laboratory animals. Traditionally, this method is actively used to study the antiepileptic activity of new molecules. However, the possibility of using ECoG to assess the neuroprotective activity of drugs in models of traumatic, vascular, metabolic, or neurodegenerative CNS damage remains clearly underestimated. Despite the fact that ECoG has a number of disadvantages and methodological difficulties, the recorded data can be a useful addition to traditional molecular and behavioral research methods. An analysis of the works in recent years indicates a growing interest in the method as a tool for assessing the pharmacological activity of psychoactive drugs, especially in combination with classification and prediction algorithms.
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