Bout duration in high-intensity interval exercise modifies hematologic, metabolic and antioxidant responses

Bogdanis, Gregory C.; Mastorakos, George; Tsirigkakis, Spyridon; Stavrinou, Pinelopi S.; Kabasakalis, Athanasios; Mantzou, Aimilia; Mougios, Vassilis

doi:10.1016/j.jesf.2022.03.005

Cited by 3 publications

(5 citation statements)

References 60 publications

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“…Hematologic responses such as plasma volume and blood count (leukocyte, neutrophil, lymphocyte, monocyte, and platelet count) have been investigated, showing that HIIE with longer duration bouts results in a greater post-exercise change in plasma volume, leukocyte, and platelet count [165]. The same tendency has been found in platelet count in healthy adults in response to firefighting drills [169], and in elite karate athletes [170].…”

Section: Healthy Individuals and Athletes Platelet Functionmentioning

confidence: 76%

“…Therefore, physical activity is capable of both preventing and inducing primary cardiac events and development of CVD, and these effects seem to be intensity-dependent [39,241]. Future research might focus on combining different exercise modes [242,243] and manipulating each component separately, such as bout duration [165,244] or investigating for the minimal dose needed to attain the benefits of a training program in maintaining hemostatic balance. Moreover, most advanced laboratory methods for the evaluation of hemostasis such as viscoelastic studies may be valuable in order to further clarify which part of the coagulation mechanism is most affected by different types of exercise [117,[245][246][247].…”

Section: Discussionmentioning

confidence: 99%

“…Although a bout of vigorous exercise (≥80% . VO 2 max) has long been considered an unsafe option for high-risk populations due to increased platelet reactivity and coagulation [39], Bogdanis et al [165] recently found that there is a duration effect on the amount of hematological influence. Regarding hemostatic activity, it is widely considered that blood fibrinolysis is increased beyond 68% .…”

Section: High-intensity Interval Exercise and Hemostatic Balancementioning

confidence: 99%

See 2 more Smart Citations

The Acute and Chronic Effects of Resistance and Aerobic Exercise in Hemostatic Balance: A Brief Review

Skouras

Antonakis-Karamintzas

Tsantes

et al. 2023

Sports

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Hemostatic balance refers to the dynamic balance between blood clot formation (coagulation), blood clot dissolution (fibrinolysis), anticoagulation, and innate immunity. Although regular habitual exercise may lower the incidence of cardiovascular diseases (CVD) by improving an individual’s hemostatic profile at rest and during exertion, vigorous exercise may increase the risk of sudden cardiac death and venous thromboembolism (VTE). This literature review aims to investigate the hemostatic system’s acute and chronic adaptive responses to different types of exercise in healthy and patient populations. Compared to athletes, sedentary healthy individuals demonstrate similar post-exercise responses in platelet function and coagulatory and fibrinolytic potential. However, hemostatic adaptations of patients with chronic diseases in regular training is a promising field. Despite the increased risk of thrombotic events during an acute bout of vigorous exercise, regular exposure to high-intensity exercise might desensitize exercise-induced platelet aggregation, moderate coagulatory parameters, and up-regulate fibrinolytic potential via increasing tissue plasminogen activator (tPA) and decreasing plasminogen activator inhibitor (PAI-1) response. Future research might focus on combining different types of exercise, manipulating each training characteristic (frequency, intensity, time, and volume), or investigating the minimal exercise dosage required to maintain hemostatic balance, especially in patients with various health conditions.

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Section: Healthy Individuals and Athletes Platelet Functionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: High-intensity Interval Exercise and Hemostatic Balancementioning

confidence: 99%

See 1 more Smart Citation

The Acute and Chronic Effects of Resistance and Aerobic Exercise in Hemostatic Balance: A Brief Review

Skouras

Antonakis-Karamintzas

Tsantes

et al. 2023

Sports

View full text Add to dashboard Cite

show abstract

“…Fourth, exercise evokes leucocyte recruitment by mobilising leucocytes into the blood circulation from the marginated pool in the blood vessels and bone marrow. [22][23][24] In situations such as immediately after an overnight bed rest, benign neutropenia may occur because neutrophils are attached to the vascular endothelium. 25 26 Considering this physiological mechanism, exercise Case report before blood is expected to be effective in leucocyte recruitment.…”

Section: Discussionmentioning

confidence: 99%

Combination of strategies to initiate clozapine for refractory schizophrenia in a patient with low neutrophil levels

et al. 2022

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Clozapine is the only drug with confirmed efficacy for refractory schizophrenia; however, its use is restricted due to the risk of potentially life-threatening side effects, such as agranulocytosis. Although this restriction ensures safety against haematological risks, some patients with refractory schizophrenia who have low neutrophil levels may miss the opportunity to receive clozapine treatment. We herein report the case of a patient with refractory schizophrenia and low neutrophil levels who was successfully initiated on clozapine treatment after the use of several methods for increasing neutrophil levels. These strategies consisted of discontinuation of antipsychotics, treatment with lithium carbonate and adenine, and light exercise before blood testing. Combining these procedures may be an effective option in the treatment of patients with refractory schizophrenia whose neutrophil levels are not sufficient to initiate clozapine.

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“…Therefore, the recovery method can affect the success of athletes by reducing cell or muscle damage indicators [8][9][10]. Because intense and long-term training can disrupt an athlete's performance by increasing oxidative stress and its effects on hematology indicators and antioxidant defense [19,20], using different methods of recovery after an acute training session can be useful. Accordingly, the aim of this research was to compare the effects of active recovery methods and massage on recovery speed in female runners.…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners

Ghobadi

Hoseini

Hasanpour

2022

JSMJ

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Background and Objectives Exercise can increase oxidative and metabolic stress. The aim of this research was to investigate the effect of different recovery methods after an acute training session on aspartate aminotransferase activity, oxidative stress, and some hematological indices of female runners. Subjects and Methods In the present quasi-experimental study, 30 semi-professional female runners were selected as the research sample and randomly divided into three groups (n=10): active running recovery, passive recovery, and sports massage. After two weeks, the same training protocol was performed for athletes and also after a week of rest, fasting blood sampling was performed. Blood sampling was performed in three stages: 1- fasting, 2- after 1500 meters competition, and 3- immediately after different stages of recovery. The one-way analysis of variance was used for statistical analysis. Results The results showed that in the massage group, the change in hematocrit, white blood cells, and hemoglobin was more than in the active and inactive recovery group (P<0.05), while in the active recovery group, the level of malondialdehyde decreased more than the massage and inactive recovery groups (P<0.05). There was no significant difference between the three recovery methods on changes in iron, red blood cells, aspartate aminotransferase, and total antioxidant capacity (P<0.05). Conclusion According to the results, it can be said that active recovery can prevent damage caused by oxidative stress by increasing blood flow.

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Bout duration in high-intensity interval exercise modifies hematologic, metabolic and antioxidant responses

Cited by 3 publications

References 60 publications

The Acute and Chronic Effects of Resistance and Aerobic Exercise in Hemostatic Balance: A Brief Review

The Acute and Chronic Effects of Resistance and Aerobic Exercise in Hemostatic Balance: A Brief Review

Combination of strategies to initiate clozapine for refractory schizophrenia in a patient with low neutrophil levels

Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners

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