Bourbon virus transmission, New York State

Dupuis, Alan P.; Prusinski, Melissa A; O’Connor, Collin; Maffei, Joseph G.; Koetzner, Cheri A.; Zembsch, Tela E; Zink, Steven D.; White, Alexis; Santoriello, Michael P; Romano, Christopher L; Xu, Guang; Ribbe, Fumiko; Campbell, Scott R.; Rich, Stephen M.; Backenson, P. Bryon; Kramer, Laura D.; Ciota, Alexander T.

doi:10.1101/2022.10.28.22281663

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…The serological surveillance of NAbs has been used in virus-endemic or emergent areas to assess pathogen distribution and exposure to resident wild and domestic animals; such methodology can also be used to monitor arboviruses within a known arboviral ecology [31][32][33]. Indeed, NAbs against POWV, BRBV, and HRTV have been detected in both wild (deer, raccoons, groundhogs, red squirrels) and domestic animals (dogs, horses) in different parts of the US-notably, in areas where human cases of these three tick-borne viruses were reported [29,[34][35][36][37]. This current study describes the first comprehensive serosurveillance of livestock and wildlife species in Virginia, and we reveal widespread exposure to POWV, BRBV, and HRTV.…”

Section: Introductionmentioning

confidence: 99%

Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock

Garba,

Riley,

Lahmers

et al. 2024

Microorganisms

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Emerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans. While limited clinical cases have been reported thus far in Virginia, the presence of tick-borne viruses poses a serious health threat, and the extent of their prevalence in Virginia is unknown. Here, we sought evidence of POWV, BRBV, and HRTV exposure in Virginia via a serological assessment of wildlife and livestock. Wildlife in Virginia were found to be seropositive against POWV (18%), BRBV (8%), and HRTV (5%), with western and northern regions of the state having a higher prevalence. Multiple wildlife species were shown to have been exposed to each virus examined. To a lesser extent, cattle also showed exposure to tick-borne viruses, with seroprevalences of 1%, 1.2%, and 8% detected in cattle against POWV, BRBV, and HRTV, respectively. Cross-reactivity against other known circulating mosquito-borne flaviviruses was ruled out. In conclusion, there is widespread exposure to tick-borne viruses in western and northern Virginia, with exposure to a diverse range of both domestic and wild animal populations. Our study provides the first confirmation that HRTV is circulating in the Commonwealth. These findings strengthen the existing evidence of emerging tick-borne viruses in Virginia and highlight the need for public health vigilance to avoid tick bites.

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